Zobrazeno 1 - 10
of 4 492
pro vyhledávání: '"Genome stability"'
Autor:
Isidoro Feliciello, Sven Ljubić, Edyta Đermić, Siniša Ivanković, Davor Zahradka, Damir Đermić
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Single-strand DNA-binding proteins SSB/RPA are ubiquitous and essential proteins that bind ssDNA in bacteria/eukaryotes and coordinate DNA metabolic processes such as replication, repair, and recombination. SSB protects ssDNA from degradatio
Externí odkaz:
https://doaj.org/article/9161e57da8c241d98b8ac0addf06c6c2
Autor:
Christophe Normand, Christophe Dez, Lise Dauban, Sophie Queille, Sarah Danché, Sarra Abderrahmane, Frederic Beckouet, Olivier Gadal
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-16 (2024)
Transcription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome. RNA polymerase I (RNAPI) is responsible for massive rRNA producti
Externí odkaz:
https://doaj.org/article/3bd5054e10f54fda9b7392c899f982b3
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-22 (2024)
Abstract Background Enhancing crops’ drought resilience is necessary to maintain productivity levels. Plants interact synergistically with microorganisms like Beauveria bassiana to improve drought tolerance. Therefore, the current study investigate
Externí odkaz:
https://doaj.org/article/377cb9e7782b44e7bf64ff7c5442bf20
Autor:
Lili Hegedus, Agnes Toth, Gabor M. Harami, Janos Palinkas, Nargis Karatayeva, Eniko Sajben-Nagy, Szabolcs Bene, Sara Afzali Jaktajdinani, Mihaly Kovacs, Szilvia Juhasz, Peter Burkovics
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Genome replication is frequently impeded by highly stable DNA secondary structures, including G-quadruplex (G4) DNA, that can hinder the progression of the replication fork. Human WRNIP1 (Werner helicase Interacting Protein 1) associates wit
Externí odkaz:
https://doaj.org/article/ef8693911000466fb2cdcfe50eeb72f6
Akademický článek
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Autor:
Miriam Yagüe-Capilla, Sean G. Rudd
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/a9e5c8a9c2f34d0ea04b807185845130
Publikováno v:
Cell Insight, Vol 3, Iss 3, Pp 100170- (2024)
The RNA-binding protein LUC7L3 is the human homolog of yeast U1 small nuclear RNA (snRNA)-related splicing factor Luc7p. While the primary function of LUC7L3 as an RNA-binding protein is believed to be involved in RNA metabolism, particularly in the
Externí odkaz:
https://doaj.org/article/26d69899a2b44e44a19e9fc2c22220a0
Autor:
Svetlana V. Sergeeva, Polina S. Loshchenova, Dmitry Yu. Oshchepkov, Konstantin E. Orishchenko
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10405 (2024)
Targeting DNA repair pathways is an important strategy in anticancer therapy. However, the unrevealed interactions between different DNA repair systems may interfere with the desired therapeutic effect. Among DNA repair systems, BER and NHEJ protect
Externí odkaz:
https://doaj.org/article/9f17a028223a48c98441aa422f2cf787
Publikováno v:
MedComm – Oncology, Vol 3, Iss 1, Pp n/a-n/a (2024)
Abstract Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The prin
Externí odkaz:
https://doaj.org/article/d2fe79e35ee747f98e85a55ae349c464
Autor:
Yu Jiang, Fei Huang, Lu Chen, Jia-Hui Gu, Yun-Wen Wu, Meng-Yan Jia, Zhen Lin, Yong Zhou, Yan-Chu Li, Chao Yu, Ming-Han Tong, Li Shen, Heng-Yu Fan, Qian-Qian Sha
Publikováno v:
Journal of Advanced Research, Vol 51, Iss , Pp 45-57 (2023)
Introduction: The R-loop is a naturally formed three-strand nucleic acid structure that recently has been reported to participate in multiple biological processes and helped answer some previously unexplained scientific questions. Meiosis process inv
Externí odkaz:
https://doaj.org/article/4890cde09fa8489fa86e42022bebe847