Zobrazeno 1 - 10
of 348
pro vyhledávání: '"Genome Regulation"'
Autor:
Kyla B. Tooley, Ana J. Chucair-Elliott, Sarah R. Ocañas, Adeline H. Machalinski, Kevin D. Pham, Walker Hoolehan, Adam M. Kulpa, David R. Stanford, Willard M. Freeman
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-27 (2023)
Abstract Background Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neuroscience, there is a pressing need to isolate and characterize the epigenomes of specific CNS cell types in hea
Externí odkaz:
https://doaj.org/article/773d1b37618b472fabb42ce59c6c91ce
Akademický článek
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Publikováno v:
National Science Open, Vol 2 (2023)
The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies, providing an unprecedented opportunity for decoding cell fate decisions largely encoded in the epigenome. Recent ad
Externí odkaz:
https://doaj.org/article/6b6877c7271644aabb37cd90aa4fa76f
Publikováno v:
Cells, Vol 12, Iss 14, p 1860 (2023)
A phenotypic hallmark of cancer is aberrant transcriptional regulation. Transcriptional regulation is controlled by a complicated array of molecular factors, including the presence of transcription factors, the deposition of histone post-translationa
Externí odkaz:
https://doaj.org/article/105dbf3d43694b309a99fa15cbea9f85
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Lamins are the ancient type V intermediate filament proteins contributing to diverse biological functions, such as the maintenance of nuclear morphology, stabilization of chromatin architecture, regulation of cell cycle progression, regulation of spa
Externí odkaz:
https://doaj.org/article/4b002233008f4afa9a005ec0702fe439
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1270-1286 (2020)
The human genome is regulated in a multi-dimensional way. While biophysical factors like Non-specific Transcription factor Binding Affinity (nTBA) act at DNA sequence level, other factors act above sequence levels such as histone modifications and 3-
Externí odkaz:
https://doaj.org/article/2f6ca010bcdb4da09bef64ff4c87a5bc
Autor:
Michal Sadowski, Agnieszka Kraft, Przemyslaw Szalaj, Michal Wlasnowolski, Zhonghui Tang, Yijun Ruan, Dariusz Plewczynski
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-27 (2019)
Abstract Background The number of reported examples of chromatin architecture alterations involved in the regulation of gene transcription and in disease is increasing. However, no genome-wide testing has been performed to assess the abundance of the
Externí odkaz:
https://doaj.org/article/30d8b3d8808d4731b7c9fca44a6675bb
Akademický článek
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Autor:
David Martín-Gálvez, Denis Dunoyer de Segonzac, Man Chun John Ma, Anne E. Kwitek, David Thybert, Paul Flicek
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background The genomes of laboratory rat strains are characterised by a mosaic haplotype structure caused by their unique breeding history. These mosaic haplotypes have been recently mapped by extensive sequencing of key strains. Comparison
Externí odkaz:
https://doaj.org/article/2209976f9c5a4ce4bc564472b75720b3
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background Transcription factors (TFs) form a complex regulatory network within the cell that is crucial to cell functioning and human health. While methods to establish where a TF binds to DNA are well established, these methods provide no
Externí odkaz:
https://doaj.org/article/5756147abd8a41f3a608c3d674e91940