Zobrazeno 1 - 10
of 2 728
pro vyhledávání: '"Genome‐wide association study (GWAS)"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cassava (Manihot esculenta Crantz) is a vital carbohydrate source for over 800 million people globally, yet its production in East Africa is severely affected by cassava brown streak disease (CBSD). Genebanks, through ex-situ conservation, p
Externí odkaz:
https://doaj.org/article/8522d95fe2e1440fa0934847373bcca0
Autor:
Jonathan P. Tyrer, Pei-Chen Peng, Amber A. DeVries, Simon A. Gayther, Michelle R. Jones, Paul D. Pharoah
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background As precision medicine advances, polygenic scores (PGS) have become increasingly important for clinical risk assessment. Many methods have been developed to create polygenic models with increased accuracy for risk prediction. Our s
Externí odkaz:
https://doaj.org/article/17d3eb6aa9614ebbb8e169af80d269e8
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background The intricate interplay between genetics and immunology often dictates the host’s susceptibility to various diseases. This study explored the genetic causal relationship between natural killer (NK) cell-related traits and the ri
Externí odkaz:
https://doaj.org/article/1c993c4993304da18222c1a67152cc50
Publikováno v:
Nutrition & Metabolism, Vol 21, Iss 1, Pp 1-8 (2024)
Abstract Background 3-Hydroxybutyrate, also called β-hydroxybutyrate, is a significant constituent of ketone bodies. Previous observational and experimental studies have suggested that ketogenic diet, especially 3-hydroxybutyrate, may have a protect
Externí odkaz:
https://doaj.org/article/5acc6650d1234673a0587c583b48389c
Autor:
Xiangyang Zhang, Zhaohui Jiang, Jiayao Ma, Yaru Qi, Yin Li, Yan Zhang, Yihan Liu, Chaochao Wei, Yihong Chen, Ping Liu, Yinghui Peng, Jun Tan, Ying Han, Shan Zeng, Changjing Cai, Hong Shen
Publikováno v:
Journal of Big Data, Vol 11, Iss 1, Pp 1-18 (2024)
Abstract Background The long-term impacts of COVID-19 on human health are a major concern, yet comprehensive evaluations of its effects on various health conditions are lacking. Methods This study aims to evaluate the role of various diseases in rela
Externí odkaz:
https://doaj.org/article/37c358585b4f48ae81803b52f33be2c5
Publikováno v:
Animal Bioscience, Vol 37, Iss 12, Pp 2054-2065 (2024)
Objective The improvement of carcass traits is essential for the Hanwoo industry because of the Hanwoo grade determination system, and genome-wide association study (GWAS) analysis is an instrumental tool for identifying the genetic factors that impa
Externí odkaz:
https://doaj.org/article/dd8bda7b3275474c8a5bd65dce8550a8
Autor:
Raya Saleh, Erik Sundberg, Mia Olsson, Katarina Tengvall, Lars Alfredsson, Ingrid Kockum, Leonid Padyukov, Helena Erlandsson Harris
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disease and the most common chronic rheumatological disease affecting children under the age of 16. The etiology of JIA remains poorly understood, but evidence suggests a
Externí odkaz:
https://doaj.org/article/d8bc63d7b96a48848186f553c014605d
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Telomere shortening and epigenetic modifications are key factors in aging and hematologic diseases. This study investigates the relationship of telomere length and epigenetic age acceleration (EAA) with hematologic cancers, blood
Externí odkaz:
https://doaj.org/article/9054af286b1b4d509aa333f2703939aa
Autor:
Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivanna M. Van Deerlin, Edward B. Lee, Charles L. White, Huw Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li-San Wang, P. S. P. genetics study group, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Gerard D. Schellenberg, Daniel H. Geschwind, Wan-Ping Lee
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP w
Externí odkaz:
https://doaj.org/article/855cdef1a9b046af9ac1a7a118950c99
Autor:
Alexia Chatziparasidou, Maria-Anna Kyrgiafini, Theologia Sarafidou, Katerina A. Moutou, Zissis Mamuris
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 6522-6532 (2024)
Azoospermia and severe oligozoospermia represent the most extreme forms of male infertility. Despite their prevalence, the genetic foundations of these conditions are not well understood, with only a limited number of genetic factors identified so fa
Externí odkaz:
https://doaj.org/article/183473e2f3764cf3b0b4726ddeaf10d4