Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Geno Saccomanno"'
Publikováno v:
Health Physics. 79:365-372
Studies of miners provide the basis for public health efforts to reduce residential radon progeny exposure. Because the preponderance of households do not have members who smoke indoors, studies of non-smoking miners contribute essential data for ris
Publikováno v:
Lung Cancer. 30:1-7
Background: A cohort of 51 consecutive patients with roentgenographically occult lung cancer, identified by sputum cytology and confirmed by bronchoscopy was reported previously. Methods: All patients have now been followed beyond 5 years and the cau
Autor:
Susan P. Proudfoot, Lee Wu, Timothy C. Kennedy, Geno Saccomanno, Melvyn S. Tockman, Steven Piantadosi, Thomas L. Petty
Publikováno v:
Acta Cytologica. 43:630-636
OBJECTIVE: To compare the efficacy of two sputum collection techniques in patients with chronic obstructive pulmonary disease (COPD) in order to diagnose dysplasia or neoplasia. STUDY DESIGN : This was a crossover study design comparing induced sputu
Autor:
William A. Palmisano, Stephen B. Baylin, Geno Saccomanno, Ruth Michels, James G. Herman, Kristen J. Nikula, Edward Gabrielson, Steven A. Belinsky
Publikováno v:
Proceedings of the National Academy of Sciences. 95:11891-11896
The p16 INK4a ( p16 ) tumor suppressor gene can be inactivated by promoter region hypermethylation in many tumor types including lung cancer, the leading cause of cancer-related deaths in the U.S. We have determined the timing of this event in an ani
Autor:
Susan Timm, Lauren A. Tierney, Marshall W. Anderson, Frank D. Gilliland, Geno Saccomanno, R E Neft, Richard E. Crowell, Minerva M. Murphy, Ruth Michels, John F. Lechner, Steven A. Belinsky
Publikováno v:
Acta Cytologica. 41:1769-1773
OBJECTIVE: A procedure was developed to allow concurrent detection of chromosome aberrations and identification of bronchial epithelial cells. STUDY DESIGN: Fluorescence in situ hybridization for chromosome 7 and immunocytochemistry for cytokeratin w
Autor:
Geno Saccomanno, Marshall W. Anderson, Elizabeth Rieniets, Jonathan S. Wiest, Kenneth Conwell, Sue Sladon Timm, Lois Davidson, Ruth Michels
Publikováno v:
Acta Cytologica. 41:1774-1780
OBJECTIVE: To compare Megafunnel slides to standard Saccomanno smear slides of sputum specimens and evaluate the use of Megafunnel slides for retrospective studies. STUDY DESIGN: Papanicolaou-stained Saccomanno smear and Megafunnel slides (Shandon Li
Autor:
M.W. Anderson, Marven Kuschner, Naomi H. Harley, Y C T Ruth Michels, Joel J. Bechtel, Oscar Auerbach, Geno Saccomanno
Publikováno v:
Cancer. 77:1278-1283
BACKGROUND Lung cancer was noted to be increased in cigarette smoking miners and nonminers. Carcinogen particulates deposit differentially in the central, middle, and peripheral zones of the bronchial tree depending on the size of the particle. The o
Autor:
Lois Davidson, Sue Sladon, Wilbur A. Franklin, Kenneth Conwell, Geno Saccomanno, Ruth Michels, John F. Lechner, J.S. Wiest, Marshall W. Anderson
Publikováno v:
Journal of Cellular Biochemistry. 63:185-190
Mutations in the p53 gene are detected in greater than 50% of squamous cell carcinomas of the lung and to a lesser extent in adenocarcinomas. The p53 protein is also overexpressed in a relatively high percentage of preinvasive lesions of the bronchia
Publikováno v:
Health physics. 87(5)
The latency of occupational cancer was a key factor in the recent epidemic of lung cancer among U.S. uranium miners. A review of the epidemic and analysis of latency periods with a near lifetime follow-up found that among former and nonsmokers, the m
Publikováno v:
Human pathology. 27(7)
The use of interactive, computerized PAPNET system (Neuromedical Systems, Inc, Suffern, NY) for screening of cervicovaginal smears has been favorably evaluated in several studies. In this article, the authors report on the performance of this apparat