Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Genny Orso"'
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The metabolic effects induced by antipsychotics in vitro depend on their action on the trafficking and biosynthesis of sterols and lipids. Previous research showed that antipsychotics with different adverse effects in patients cause similar
Externí odkaz:
https://doaj.org/article/6b84e77cd1bb40b696d3b54087971c72
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Hereditary spastic paraplegia (HSP) is a group of inherited neurodegenerative conditions that share a characteristic feature of degeneration of the longest axons within the corticospinal tract, which leads to progressive spasticity and weakness of th
Externí odkaz:
https://doaj.org/article/78382e9efced41628670f039e659db03
Autor:
Isabella Giacomini, Federico Gianfanti, Maria Andrea Desbats, Genny Orso, Massimiliano Berretta, Tommaso Prayer-Galetti, Eugenio Ragazzi, Veronica Cocetta
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane physical properties, while its metabolism is involved in bile
Externí odkaz:
https://doaj.org/article/5b1ff14691c141cfb41ef29b799ec857
Autor:
Barbara Napoli, Sentiljana Gumeni, Alessia Forgiarini, Marianna Fantin, Concetta De Filippis, Elena Panzeri, Chiara Vantaggiato, Genny Orso
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Defects in the endoplasmic reticulum (ER) membrane shaping and interaction with other organelles seem to be a crucial mechanism underlying Hereditary Spastic Paraplegia (HSP) neurodegeneration. REEP1, a transmembrane protein belonging to TB2/HVA22 fa
Externí odkaz:
https://doaj.org/article/c6ba2cae6b5549b4bbc8de283ae86ae6
Autor:
Diego Scheggia, Rosa Mastrogiacomo, Maddalena Mereu, Sara Sannino, Richard E. Straub, Marco Armando, Francesca Managò, Simone Guadagna, Fabrizio Piras, Fengyu Zhang, Joel E. Kleinman, Thomas M. Hyde, Sanne S. Kaalund, Maria Pontillo, Genny Orso, Carlo Caltagirone, Emiliana Borrelli, Maria A. De Luca, Stefano Vicari, Daniel R. Weinberger, Gianfranco Spalletta, Francesco Papaleo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, pro
Externí odkaz:
https://doaj.org/article/0e5f124f37b14a83811e7cceee5dc56c
Autor:
Concetta De Filippis, Barbara Napoli, Laura Rigon, Giulia Guarato, Reinhard Bauer, Rosella Tomanin, Genny Orso
Publikováno v:
Cells, Vol 11, Iss 1, p 129 (2021)
Deficit of the IDUA (α-L-iduronidase) enzyme causes the lysosomal storage disorder mucopolysaccharidosis type I (MPS I), a rare pediatric neurometabolic disease, due to pathological variants in the IDUA gene and is characterized by the accumulation
Externí odkaz:
https://doaj.org/article/829d147ff55f4946a46425ce960c5f0b
Autor:
Chiara Vantaggiato, Marianna Castelli, Matteo Giovarelli, Genny Orso, Maria Teresa Bassi, Emilio Clementi, Clara De Palma
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Mitochondria play a critical role in neuronal function and neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington diseases and amyotrophic lateral sclerosis, that show mitochondrial dysfunctions associated with excessive f
Externí odkaz:
https://doaj.org/article/2ef05c5835104729be32cdfddbb6c496
Autor:
Alessia Forgiarini, Zifei Wang, Claudio D'Amore, Morgan Jay-Smith, Freda Fan Li, Brian Hopkins, Margaret Anne Brimble, Andrea Pagetta, Sara Bersani, Sara De Martin, Barbara Napoli, Sergio Bova, David Rennison, Genny Orso
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0211169 (2019)
In this study we investigated the performance of two norbormide (NRB)-derived fluorescent probes, NRBMC009 (green) and NRBZLW0047 (red), on dissected, living larvae of Drosophila, to verify their potential application in live cell imaging confocal mi
Externí odkaz:
https://doaj.org/article/e764cf9376a44bcf9129ba309e774b1a
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 268 (2021)
Lysosomal storage disorders (LSDs) represent a complex and heterogeneous group of rare genetic diseases due to mutations in genes coding for lysosomal enzymes, membrane proteins or transporters. This leads to the accumulation of undegraded materials
Externí odkaz:
https://doaj.org/article/9847a64346e34d339c01cd3cd033f47c
Autor:
Miriam Saponaro, Isabella Giacomini, Giulia Morandin, Veronica Cocetta, Eugenio Ragazzi, Genny Orso, Ilaria Carnevali, Massimiliano Berretta, Mariangela Mancini, Francesco Pagano, Monica Montopoli
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9178 (2020)
Benign prostatic hyperplasia (BPH) is an age-related chronic disorder, characterized by the hyperproliferation of prostatic epithelial and stromal cells, which drives prostate enlargement. Since BPH aetiology and progression have been associated with
Externí odkaz:
https://doaj.org/article/6acc086e23324cb69b42f0504c1fb3cf