Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gennie L. Parkman"'
Autor:
Aria Vaishnavi, Michael T. Scherzer, Conan G. Kinsey, Gennie L. Parkman, Amanda Truong, Phaedra Ghazi, Sophia Schuman, Benjamin Battistone, Ignacio Garrido-Laguna, Martin McMahon
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107994- (2020)
Summary: NTRK1 gene fusions are actionable drivers of numerous human malignancies. Here, we show that expression of the TPR-NTRK1 fusion kinase in immortalized mouse pancreatic ductal epithelial (IMPE) (pancreas) or mouse lung epithelial (MLE-12) cel
Externí odkaz:
https://doaj.org/article/17c5dbf5b7bd4d12976eee924b66ab0f
Autor:
Sheri L. Holmen, Matthew W. VanBrocklin, Michelle C. Mendoza, Michael A. Davies, Martin McMahon, Kenneth M. Boucher, Keith L. Duffy, Allie H. Grossmann, Sean C. Strain, Christopher M. Stehn, Stephanie N. Angel, Grant M. Fischer, Gennie L. Parkman, Mark R. Silvis, Kirby A. Trombetti, David A. Kircher
Supplementary Figure 6. Expression of AKT1E17K promotes the dysregulation of integrins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9454b5a10eb9a2a4fe403f92b1302221
https://doi.org/10.1158/1541-7786.22514937
https://doi.org/10.1158/1541-7786.22514937
Autor:
Sheri L. Holmen, Matthew W. VanBrocklin, Michelle C. Mendoza, Michael A. Davies, Martin McMahon, Kenneth M. Boucher, Keith L. Duffy, Allie H. Grossmann, Sean C. Strain, Christopher M. Stehn, Stephanie N. Angel, Grant M. Fischer, Gennie L. Parkman, Mark R. Silvis, Kirby A. Trombetti, David A. Kircher
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032b32ea8a6305ee92a068d90d7dffaa
https://doi.org/10.1158/1541-7786.22514931
https://doi.org/10.1158/1541-7786.22514931
Autor:
Sheri L. Holmen, Matthew W. VanBrocklin, Michelle C. Mendoza, Michael A. Davies, Martin McMahon, Kenneth M. Boucher, Keith L. Duffy, Allie H. Grossmann, Sean C. Strain, Christopher M. Stehn, Stephanie N. Angel, Grant M. Fischer, Gennie L. Parkman, Mark R. Silvis, Kirby A. Trombetti, David A. Kircher
Supplementary Table 1. Summary of tumor formation in Dct::TVA mice. .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3017ffd947ea0fe45b16e31e2e6d917e
https://doi.org/10.1158/1541-7786.22514928.v1
https://doi.org/10.1158/1541-7786.22514928.v1
Publikováno v:
Exp Dermatol
Phosphatidylinositol-3’-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3’ hydroxyl (OH) of the inositol ring of phosphatidylinositides (PI). Through their downstream effectors, PI3K generated lipids (PI3K-lipids hereafter) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e04980fee2d8171c3c0a1c7bee9343c
https://doi.org/10.1111/exd.14489
https://doi.org/10.1111/exd.14489
Autor:
Gennie L. Parkman, Tursun Turapov, David A. Kircher, William J. Burnett, Christopher M. Stehn, Kayla O’Toole, Ryan Flaherty, Riley C. Elmer, Katie M. Culver, Mona Foth, Robert H. I. Andtbacka, David H. Lum, Robert Judson-Torres, Matthew W. VanBrocklin, Sheri L. Holmen, Martin McMahon
Aberrant activation of the PI3K-AKT pathway is common in melanoma but efforts to drug this pathway have proven largely ineffective in patients. In this study, we observed that pharmacological inhibition of AKT was ineffective whereas genetic silencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c4e543a02c06128ce930fbb3f826ad
https://doi.org/10.1101/2022.08.15.504039
https://doi.org/10.1101/2022.08.15.504039
Autor:
Gennie L. Parkman, Tursun Turapov, David Kircher, William Burnett, Christopher Stehn, Kayla O'Toole, Katie Culver, Ashley Chadwick, Riley Elmer, Ryan Flaherty, Mona Foth, Karly Stanley, Robert Andtbacka, David Lum, Robert Judson-Torres, Martin McMahon, Sheri Holmen
Publikováno v:
Cancer Research. 83:427-427
Despite the advent of novel therapies, the five year survival rate for Stage IV melanoma remains at only 30%. This highlights the critical need for new therapeutics to treat this refractory disease. Aberrant activation of the PI3K-AKT pathway is comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c91a92d276b161158d889b3fa476eb48
https://doi.org/10.1158/1538-7445.am2023-427
https://doi.org/10.1158/1538-7445.am2023-427
Publikováno v:
Pigment Cell Melanoma Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa91ac620093f9d4af40a943b7dcbeac
https://doi.org/10.1111/pcmr.12940
https://doi.org/10.1111/pcmr.12940
Autor:
Kenneth M. Boucher, Matthew W. VanBrocklin, Mark R. Silvis, Michael A. Davies, Michelle C. Mendoza, Stephanie N. Angel, Gennie L. Parkman, David A. Kircher, Sean C. Strain, Keith L. Duffy, Christopher M. Stehn, Kirby A. Trombetti, Grant M. Fischer, Martin McMahon, Sheri L. Holmen, Allie H. Grossmann
Publikováno v:
Molecular Cancer Research. 17:1787-1800
Alterations in the PI3K/AKT pathway occur in up to 70% of melanomas and are associated with disease progression. The three AKT paralogs are highly conserved but data suggest they have distinct functions. Activating mutations of AKT1 and AKT3 occur in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccde3b7d07621e3cce68fcdb29e526bd
https://doi.org/10.1158/1541-7786.mcr-18-1372
https://doi.org/10.1158/1541-7786.mcr-18-1372
Autor:
Conan G. Kinsey, Benjamin Battistone, Michael T. Scherzer, Amanda Truong, Phaedra Ghazi, Ignacio Garrido-Laguna, Martin McMahon, Aria Vaishnavi, Gennie L. Parkman, Sophia S. Schuman
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107994-(2020)
Cell Rep
Cell Rep
Summary NTRK1 gene fusions are actionable drivers of numerous human malignancies. Here, we show that expression of the TPR-NTRK1 fusion kinase in immortalized mouse pancreatic ductal epithelial (IMPE) (pancreas) or mouse lung epithelial (MLE-12) cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2025a47cb54e695fc0aea880faac29c0
http://www.sciencedirect.com/science/article/pii/S2211124720309797
http://www.sciencedirect.com/science/article/pii/S2211124720309797