Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Gennemark, P."'
Autor:
Rezaei, Mitra, Arjmandi, Hamidreza, Zoofaghari, Mohammad, Kanebratt, Kajsa, Vilen, Liisa, Janzen, David, Gennemark, Peter, Noel, Adam
Recent molecular communication (MC) research has integrated more detailed computational models to capture the dynamics of practical biophysical systems. This research focuses on developing realistic models for MC transceivers inspired by spheroids -
Externí odkaz:
http://arxiv.org/abs/2312.04427
Autor:
Sophie Rigal, Belén Casas, Kajsa P. Kanebratt, Charlotte Wennberg Huldt, Lisa U. Magnusson, Erik Müllers, Fredrik Karlsson, Maryam Clausen, Sara F. Hansson, Louise Leonard, Jonathan Cairns, Rasmus Jansson Löfmark, Carina Ämmälä, Uwe Marx, Peter Gennemark, Gunnar Cedersund, Tommy B. Andersson, Liisa K. Vilén
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-23 (2024)
Abstract Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of key metabolic organs, the pancreas and liv
Externí odkaz:
https://doaj.org/article/6ef35220f5cb430495895d01dab6b095
Autor:
Arjmandi, Hamidreza, Zoofaghari, Mohamad, Rezaei, Mitra, Kanebratt, Kajsa, Vilen, Liisa, Janzen, David, Gennemark, Peter, Noel, Adam
Realistic models of the components and processes are required for molecular communication (MC) systems. In this paper, a spheroidal receiver structure is proposed for MC that is inspired by the 3D cell cultures known as spheroids being widely used in
Externí odkaz:
http://arxiv.org/abs/2302.09265
Autor:
Tilda Herrgårdh, Christian Simonsson, Mattias Ekstedt, Peter Lundberg, Karin G. Stenkula, Elin Nyman, Peter Gennemark, Gunnar Cedersund
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-20 (2023)
Abstract Background The increased prevalence of insulin resistance is one of the major health risks in society today. Insulin resistance involves both short-term dynamics, such as altered meal responses, and long-term dynamics, such as the developmen
Externí odkaz:
https://doaj.org/article/513807bc153f4c39b36e53a19c7af91a
Autor:
Erica Bäckström, Alessandro Bonetti, Per Johnsson, Stefan Öhlin, Anders Dahlén, Patrik Andersson, Shalini Andersson, Peter Gennemark
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102133- (2024)
Pharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination driven by re-distribution from tissue. Quantitative understanding of tissue PK and RNA knockd
Externí odkaz:
https://doaj.org/article/620e8b00bb8c445db2c105ba320b4cfe
Akademický článek
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Autor:
Jane Knöchel, Catarina Nilsson, Björn Carlsson, Linda Wernevik, Alexis Hofherr, Peter Gennemark, Rasmus Jansson‐Löfmark, Rikard Isaksson, Tina Rydén‐Bergsten, Bengt Hamrén, Dinko Rekić
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 12, Pp 1569-1577 (2022)
Abstract Here, we show model‐informed drug development (MIDD) of a novel antisense oligonucleotide, targeting PCSK9 for treatment of hypocholesteremia. The case study exemplifies use of MIDD to analyze emerging data from an ongoing first‐in‐hum
Externí odkaz:
https://doaj.org/article/e7f981bc8d2c4134ac07a117e385317e
Akademický článek
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Autor:
Belén Casas, Liisa Vilén, Sophie Bauer, Kajsa P Kanebratt, Charlotte Wennberg Huldt, Lisa Magnusson, Uwe Marx, Tommy B Andersson, Peter Gennemark, Gunnar Cedersund
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010587 (2022)
Microphysiological systems (MPS) are powerful tools for emulating human physiology and replicating disease progression in vitro. MPS could be better predictors of human outcome than current animal models, but mechanistic interpretation and in vivo ex
Externí odkaz:
https://doaj.org/article/4a3bbcd9a4d74df2beadb1ea5c7164c8
Akademický článek
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