Výsledky vyhledávání - "Gennaro Prota"

Akademický článek

Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

Autor: Matheswaran Kandasamy, Uzi Gileadi, Pramila Rijal, Tiong Kit Tan, Lian N Lee, Jili Chen, Gennaro Prota, Paul Klenerman, Alain Townsend, Vincenzo Cerundolo

Publikováno v: eLife, Vol 12 (2023)

Virus-based tumour vaccines offer many advantages compared to other antigen-delivering systems. They generate concerted innate and adaptive immune response, and robust CD8+ T cell responses. We engineered a non-replicating pseudotyped influenza virus

Externí odkaz: https://doaj.org/article/19381c4da57642bb86445baca9176ae3

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Akademický článek

Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1157-165 tumor-specific peptide

Autor: Vincenzo Cerundolo, Eugene Shenderov, Matheswaran Kandasamy, Uzi Gileadi, Jili Chen, Dawn Shepherd, James Gibbs, Gennaro Prota, Jonathan D Silk, Jonathan W Yewdell

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)

Background NY-ESO-1 is a tumor-specific, highly immunogenic, human germ cell antigen of the MAGE-1 family that is a promising vaccine and cell therapy candidate in clinical trial development. The mouse genome does not encode an NY-ESO-1 homolog there

Externí odkaz: https://doaj.org/article/a24b481c56034796b4410d660f7ec87d

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Akademický článek

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses

Autor: Daniele Corridoni, Seiji Shiraishi, Thomas Chapman, Tessa Steevels, Daniele Muraro, Marie-Laëtitia Thézénas, Gennaro Prota, Ji-Li Chen, Uzi Gileadi, Nicola Ternette, Vincenzo Cerundolo, Alison Simmons

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

NOD2 and TLR2 recognize components of bacterial cell wall peptidoglycan and direct defense against enteric pathogens. CD8+ T cells are important for immunity to such pathogens but how NOD2 and TLR2 induce antigen specific CD8+ T cell responses is unk

Externí odkaz: https://doaj.org/article/9eb738e749514517b1f3c064aa982497

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Akademický článek

A Stochastic Model for CD4+ T Cell Proliferation and Dissemination Network in Primary Immune Response.

Autor: Alessandro Boianelli, Elena Pettini, Gennaro Prota, Donata Medaglini, Antonio Vicino

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135787 (2015)

The study of the initial phase of the adaptive immune response after first antigen encounter provides essential information on the magnitude and quality of the immune response. This phase is characterized by proliferation and dissemination of T cells

Externí odkaz: https://doaj.org/article/fe57dd0441874215a560165e2277695e

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Akademický článek

Vaginal immunization to elicit primary T-cell activation and dissemination.

Autor: Elena Pettini, Gennaro Prota, Annalisa Ciabattini, Alessandro Boianelli, Fabio Fiorino, Gianni Pozzi, Antonio Vicino, Donata Medaglini

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e80545 (2013)

Primary T-cell activation at mucosal sites is of utmost importance for the development of vaccination strategies. T-cell priming after vaginal immunization, with ovalbumin and CpG oligodeoxynucleotide adjuvant as model vaccine formulation, was studie

Externí odkaz: https://doaj.org/article/0685d1b0fe5a407a8053ca09995373ee

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Akademický článek

Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice.

Autor: Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Gennaro Prota, Gianni Pozzi, Donata Medaglini

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e19346 (2011)

Priming of T cells is a key event in vaccination, since it bears a decisive influence on the type and magnitude of the immune response. T-cell priming after mucosal immunization via the nasal route was studied by investigating the distribution of ant

Externí odkaz: https://doaj.org/article/8c769d358800441283c825ff59a703e5

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