Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Gennaro Gambardella"'
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Most primary Triple Negative Breast Cancers (TNBCs) show amplification of the Epidermal Growth Factor Receptor (EGFR) gene, leading to increased protein expression. However, unlike other EGFR-driven cancers, targeting this recepto
Externí odkaz:
https://doaj.org/article/036f678330144a45b4e6b9e53bef263c
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Intra-tumour heterogeneity (ITH) presents a significant obstacle in formulating effective treatment strategies in clinical practice. Single-cell RNA sequencing (scRNA-seq) has evolved as a powerful instrument for probing ITH at th
Externí odkaz:
https://doaj.org/article/5619108741b24d43999d6024ad171e4a
Autor:
Ermes Candiello, Gigliola Reato, Federica Verginelli, Gennaro Gambardella, Antonio D′Ambrosio, Noemi Calandra, Francesca Orzan, Antonella Iuliano, Raffaella Albano, Francesco Sassi, Paolo Luraghi, Paolo M. Comoglio, Andrea Bertotti, Livio Trusolino, Carla Boccaccio
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1280-1301 (2023)
In colorectal cancer, the mechanisms underlying tumor aggressiveness require further elucidation. Taking advantage of a large panel of human metastatic colorectal cancer xenografts and matched stem‐like cell cultures (m‐colospheres), here we show
Externí odkaz:
https://doaj.org/article/dc608abc77b544188c157027dd27b4aa
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/4a96212e5421441abb5bc6f8619f2e5d
Autor:
Serena Brundu, Virginia Napolitano, Giulia Franzolin, Ettore Lo Cascio, Roberta Mastrantonio, Gabriele Sardo, Eliano Cascardi, Federica Verginelli, Sergio Sarnataro, Gennaro Gambardella, Alberto Pisacane, Alessandro Arcovito, Carla Boccaccio, Paolo M Comoglio, Enrico Giraudo, Luca Tamagnone
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 3, Pp 1-20 (2023)
Abstract The genetic changes sustaining the development of cancers of unknown primary (CUP) remain elusive. The whole‐exome genomic profiling of 14 rigorously selected CUP samples did not reveal specific recurring mutation in known driver genes. Ho
Externí odkaz:
https://doaj.org/article/987698c7f10d4c4294c18aba6c9e4084
Autor:
Rossella De Cegli, Diego Carrella, Diletta Siciliano, Gennaro Gambardella, Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio, Diego di Bernardo
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 295-305 (2022)
TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with experimen
Externí odkaz:
https://doaj.org/article/b853148c25984783b87dad7ca2b37b7b
Autor:
Federica Verginelli, Alberto Pisacane, Gennaro Gambardella, Antonio D’Ambrosio, Ermes Candiello, Marco Ferrio, Mara Panero, Laura Casorzo, Silvia Benvenuti, Eliano Cascardi, Rebecca Senetta, Elena Geuna, Andrea Ballabio, Filippo Montemurro, Anna Sapino, Paolo M. Comoglio, Carla Boccaccio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to
Externí odkaz:
https://doaj.org/article/4477922c33134d2989690669cbc5e8c0
Autor:
Silvia Benvenuti, Melissa Milan, Elena Geuna, Alberto Pisacane, Rebecca Senetta, Gennaro Gambardella, Giulia M Stella, Filippo Montemurro, Anna Sapino, Carla Boccaccio, Paolo M Comoglio
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp 1-10 (2020)
Abstract Cancer of unknown primary (CUP) is an obscure disease characterized by multiple metastases in the absence of a primary tumor. No consensus has been reached whether CUPs are simply generated from cancers that cannot be detected or whether the
Externí odkaz:
https://doaj.org/article/a3a098358273454aa580ffa5d68aa70d
Autor:
Elisa Pedone, Mario Failli, Gennaro Gambardella, Rossella De Cegli, Antonella La Regina, Diego di Bernardo, Lucia Marucci
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103756- (2022)
Summary: The Wnt/β-catenin pathway is involved in development, cancer, and embryonic stem cell (ESC) maintenance; its dual role in stem cell self-renewal and differentiation is still controversial. Here, by applying an in vitro system enabling induc
Externí odkaz:
https://doaj.org/article/cacc30bdd4124a6dbb2dd0cf5f56a28c
Autor:
Gennaro Gambardella, Annamaria Carissimo, Amy Chen, Luisa Cutillo, Tomasz J. Nowakowski, Diego di Bernardo, Robert Blelloch
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
MicroRNAs can posttranscriptionally repress multiple targets in a cell population. Here the authors use single-cell sequencing to investigate the effects of an individual miRNA on transcriptional heterogeneity and gene co-expression
Externí odkaz:
https://doaj.org/article/915b924b7b1a49c5860ec77d7652288d