Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Gennady M. Butov"'
Autor:
Vladimir V. Burmistrov, Christophe Morisseau, Dmitry V. Danilov, Boris P. Gladkikh, Vladimir S. D’yachenko, Nikolay A. Zefirov, Olga N. Zefirova, Gennady M. Butov, Bruce D. Hammock
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measure
Externí odkaz:
https://doaj.org/article/a8df2f9e00794074bf2bbc27e9abe427
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 338 (2023)
Soluble epoxide hydrolase (sEH) is an enzyme involved in the metabolism of bioactive lipid signaling molecules. sEH converts epoxyeicosatrienoic acids (EET) to virtually inactive dihydroxyeicosatrienoic acids (DHET). The first acids are “medicinal
Externí odkaz:
https://doaj.org/article/7e6e78a8b5544459886ade849cdc5095
Publikováno v:
Molbank, Vol 2023, Iss 1, p M1585 (2023)
The title compound, (Z)-2′-((adamantan-1-yl)thio)-1,1′-dimethyl-2′,3′-dihydro-[2,4′-biimidazolylidene]-4,5,5′(1H,1′H,3H)-trione, was found to be a by-product of the reaction of 1,3-dehydroadamantane with 3-methyl-2-thioxoimidazolidin-4-
Externí odkaz:
https://doaj.org/article/36eb9643f0ce40559168f95b241a38e2
Autor:
Vladimir Burmistrov, Christophe Morisseau, Dmitry Pitushkin, Robert R. Fayzullin, Dmitry Karlov, Andrey Vernigora, Yaroslav Kuznetsov, Saeef M.H. Abbas, Gennady M. Butov, Bruce D. Hammock
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100653- (2022)
The soluble epoxide hydrolase (sEH) is a potential target to treat cardiovascular, renal and neuronal diseases. A series of sEH inhibitors containing naturally occurring lipophilic groups (originating from camphor and fenchone) were developed. Inhibi
Externí odkaz:
https://doaj.org/article/3e9fca140d624ed4b827229aef9d2074
Autor:
Vladimir Burmistrov, Christophe Morisseau, Denis A. Babkov, Tatiana Golubeva, Dmitry Pitushkin, Elena V. Sokolova, Vladimir Vasipov, Yaroslav Kuznetsov, Sergey V. Bazhenov, Uliana S. Novoyatlova, Nikolay A. Bondarev, Ilya V. Manukhov, Victoria Osipova, Nadezhda Berberova, Alexander A. Spasov, Gennady M. Butov, Bruce D. Hammock
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10710 (2022)
The inhibitory potency of the series of inhibitors of the soluble epoxide hydrolase (sEH) based on the selenourea moiety and containing adamantane and aromatic lipophilic groups ranges from 34.3 nM to 1.2 μM. The most active compound 5d possesses al
Externí odkaz:
https://doaj.org/article/4b78819e3bdf46698fec5c70c50137b4
Autor:
Boris P. Gladkikh, Vladimir S. D'yachenko, Vladimir V. Burmistrov, Gennady M. Butov, Ivan A. Novakov
Publikováno v:
Mendeleev Communications. 32:683-685
Autor:
V. V. Burmistrov, D. A. Pitushkin, Gennady M. Butov, A. V. Eshtukov, Ya. P. Kuznetsov, E. V. Rasskazova, V. V. Vasipov
Publikováno v:
Russian Journal of Organic Chemistry. 57:1036-1046
A series of N,N′-disubstituted selenoureas containing an adamantane fragment have been synthesized in 23–75% yields. Procedures for the isolation and purification of aromatic isoselenocyanates have been improved. The chemical shift of the C=Se ca
Publikováno v:
Russian Chemical Bulletin. 70:1067-1074
This brief review highlights the history of the discovery of the phosphatase domain of human soluble epoxide hydrolase (sEH-P). The data on its structure and physiological role are summarized. State-of-the-art methods for the evaluation of the inhibi
Publikováno v:
Russian Journal of Organic Chemistry. 57:784-792
The reactions of 1-isobutyl-4-(1-isocyanatoethyl)benzene with various amines and of 1-(4-isobutylphenyl)ethanamine with halogenated aromatic isocyanates gave a series of ureas containing an ibuprofen fragment in their structure. The yields of the tar
Autor:
Ya. P. Kuznetsov, E. K. Degtyarenko, V. V. Burmistrov, A. A. Vernigora, D. A. Pitushkin, M. H. Abbas Saeef, Gennady M. Butov
Publikováno v:
Russian Journal of Organic Chemistry. 57:515-523
N,N′-Disubstituted ureas and thioureas containing a lipophilic optically active natural bicyclic moiety have been synthesized by reactions of (R)-, (S)-, and (RS)-1,1,7-trimethylbicyclo[2.2.1]heptan-2-amines with aromatic isocyanates and isothiocya