Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Gennady G. Yegutkin"'
Autor:
Nataliia Petruk, Sanni Tuominen, Malin Åkerfelt, Jesse Mattsson, Jouko Sandholm, Matthias Nees, Gennady G. Yegutkin, Arja Jukkola, Johanna Tuomela, Katri S. Selander
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract CD73 is a cell surface ecto-5′-nucleotidase, which converts extracellular adenosine monophosphate to adenosine. High tumor CD73 expression is associated with poor outcome among triple-negative breast cancer (TNBC) patients. Here we investi
Externí odkaz:
https://doaj.org/article/b2c631e7001b40c2910848b8522fac2a
Autor:
Daichi Kobayashi, Yuki Sugiura, Eiji Umemoto, Akira Takeda, Hisashi Ueta, Haruko Hayasaka, Shinsuke Matsuzaki, Tomoya Katakai, Makoto Suematsu, Itaru Hamachi, Gennady G. Yegutkin, Marko Salmi, Sirpa Jalkanen, Masayuki Miyasaka
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Whereas adenosine 5’-triphosphate (ATP) is the major energy source in cells, extracellular ATP (eATP) released from activated/damaged cells is widely thought to represent a potent damage-associated molecular pattern that promotes inflammatory respo
Externí odkaz:
https://doaj.org/article/97740f20ca8d49139c8d35c2edaa2c0f
Autor:
Anren Song, Yujin Zhang, Leng Han, Gennady G. Yegutkin, Hong Liu, Kaiqi Sun, Angelo D’Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama, Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu, Travis Nemkov, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Kirk C. Hansen, Hong Zhang, Mikhail Bogdanov, William Dowhan, Jianping Jin, Rodney E. Kellems, Holger K. Eltzschig, Michael Blackburn, Robert C. Roach, Yang Xia
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter E
Externí odkaz:
https://doaj.org/article/ab90ef4532bf424aa26dc070a2adc9be
Autor:
Bradley N. Spatola, Alana G. Lerner, Clifford Wong, Tracy dela Cruz, Megan Welch, Wanchi Fung, Maria Kovalenko, Karolina Losenkova, Gennady G. Yegutkin, Courtney Beers, John Corbin, Vanessa B. Soros
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The extracellular ATP/adenosine axis in the tumor microenvironment (TME) has emerged as an important immune-regulatory pathway. Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), otherwise known as CD39, is highly expressed in the TME, both on
Externí odkaz:
https://doaj.org/article/8bced6b671a140d282b142fc5d12124b
Autor:
Gennady G. Yegutkin, Detlev Boison
Publikováno v:
Pharmacol Rev
Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic processes, including immunomodulation and cell proliferation. Tumors create an adenosine-rich immunosuppressive microenvironment through the increased releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fffde98cd02bbbbfdd62fe0e98dc314
https://doi.org/10.1124/pharmrev.121.000528
https://doi.org/10.1124/pharmrev.121.000528
Autor:
Gennady G. Yegutkin, Sirpa Jalkanen, Pirkko L. Härkönen, Kati Elima, Minna Vainio, Anu Kukkonen-Macchi, Sanna S. Virtanen
Supplementary Figure S2. The effect of adenosine on the kinetics of cell adhesion to extracellular matrix and MMP secretion by PC-3 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aa7cd263f3b8b6f912d0be1f4118f0
https://doi.org/10.1158/1541-7786.22511589.v1
https://doi.org/10.1158/1541-7786.22511589.v1
Autor:
Gennady G. Yegutkin, Sirpa Jalkanen, Pirkko L. Härkönen, Kati Elima, Minna Vainio, Anu Kukkonen-Macchi, Sanna S. Virtanen
Extracellular adenosine mediates diverse anti-inflammatory, angiogenic, and other signaling effects via binding to adenosine receptors, and it also regulates cell proliferation and death via activation of the intrinsic signaling pathways. Given the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba785f63b08b3d5981c45ab01d650f48
https://doi.org/10.1158/1541-7786.c.6539982.v1
https://doi.org/10.1158/1541-7786.c.6539982.v1
Autor:
Kenneth A. Jacobson, Mirko Scortichini, Riham M. Idris, Susanne Moschütz, Antje Keim, Veronica A. Salmaso, Clemens Dobelmann, Paola A. Oliva, Karolina Losenkova, Heikki Irjala, Samuli Vaittinen, Jouko Sandholm, Gennady G. Yegutkin, Norbert Sträter, Anna Junker, Christa E. Müller
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1ffef5b7605e42873b5327ca2ba53d
https://doi.org/10.1096/fasebj.2022.36.s1.r3981
https://doi.org/10.1096/fasebj.2022.36.s1.r3981
Autor:
Karolina Losenkova, Riham M. Idris, Yulu Wang, Laura Schäkel, Christian Renn, Constanze C. Schmies, Georg Rolshoven, Gennady G. Yegutkin, Francesca Garofano, Christa E. Müller, Haneen Al-Hroub, Ingo G.H. Schmidt-Wolf, Herbert Zimmermann
Publikováno v:
ACS Med Chem Lett
[Image: see text] Ecto-5′-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a9bf386645b298c5f684bf50b8f276
https://doi.org/10.1021/acsmedchemlett.0c00391
https://doi.org/10.1021/acsmedchemlett.0c00391
Autor:
Karolina Losenkova, Akira Takeda, Symantas Ragauskas, Marc Cerrada-Gimenez, Maria Vähätupa, Simon Kaja, Marius L. Paul, Constanze C. Schmies, Georg Rolshoven, Christa E. Müller, Jouko Sandholm, Sirpa Jalkanen, Giedrius Kalesnykas, Gennady G. Yegutkin
Publikováno v:
Cellular and Molecular Life Sciences. 79
ATP and adenosine have emerged as important signaling molecules involved in vascular remodeling, retinal functioning and neurovascular coupling in the mammalian eye. However, little is known about the regulatory mechanisms of purinergic signaling in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9e47fff3564e83ba322c099857abf2
https://doi.org/10.1007/s00018-022-04187-4
https://doi.org/10.1007/s00018-022-04187-4