Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Gennady G Yegutkin"'
Autor:
Heli Elovaara, Teija Huusko, Mikael Maksimow, Kati Elima, Gennady G Yegutkin, Mikael Skurnik, Ulrich Dobrindt, Anja Siitonen, Michael J McPherson, Marko Salmi, Sirpa Jalkanen
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142367 (2015)
Escherichia coli amine oxidase (ECAO), encoded by the tynA gene, catalyzes the oxidative deamination of aromatic amines into aldehydes through a well-established mechanism, but its exact biological role is unknown. We investigated the role of ECAO by
Externí odkaz:
https://doaj.org/article/6884bd5528544c18936da041fdf6f3c9
Autor:
Natalia Kulesskaya, Vootele Võikar, Marjaana Peltola, Gennady G Yegutkin, Marko Salmi, Sirpa Jalkanen, Heikki Rauvala
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66896 (2013)
CD73 (ecto-5'-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. 5'-nucleotidases are known to be expressed in brain, but the expression of CD73 and its putative physiolog
Externí odkaz:
https://doaj.org/article/4527b64461ec4b1aa2c8689470282c0f
Autor:
Tuomas Oskari Kiviniemi, Gennady G Yegutkin, Jyri eToikka, Subhadeep ePaul, Tero eAittokallio, Tuula eJanatuinen, Juhani eKnuuti, Tapani eRönnemaa, Juha eKoskenvuo, Jaakko eHartiala, Sirpa eJalkanen, Olli Tuomas Raitakari
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Aims: Extracellular ATP and ADP regulate diverse inflammatory, prothrombotic and vasoactive responses in the vasculature. Statins have been shown to modulate their signaling pathways in vitro. We hypothesized that altered intravascular nucleotide tur
Externí odkaz:
https://doaj.org/article/221283b3a8de4d7b9e9f0ccdcd1a3a1f
Autor:
Gennady G. Yegutkin, Detlev Boison
Publikováno v:
Pharmacol Rev
Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic processes, including immunomodulation and cell proliferation. Tumors create an adenosine-rich immunosuppressive microenvironment through the increased releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fffde98cd02bbbbfdd62fe0e98dc314
https://doi.org/10.1124/pharmrev.121.000528
https://doi.org/10.1124/pharmrev.121.000528
Autor:
Gennady G. Yegutkin, Sirpa Jalkanen, Pirkko L. Härkönen, Kati Elima, Minna Vainio, Anu Kukkonen-Macchi, Sanna S. Virtanen
Supplementary Figure S2. The effect of adenosine on the kinetics of cell adhesion to extracellular matrix and MMP secretion by PC-3 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aa7cd263f3b8b6f912d0be1f4118f0
https://doi.org/10.1158/1541-7786.22511589.v1
https://doi.org/10.1158/1541-7786.22511589.v1
Autor:
Gennady G. Yegutkin, Sirpa Jalkanen, Pirkko L. Härkönen, Kati Elima, Minna Vainio, Anu Kukkonen-Macchi, Sanna S. Virtanen
Extracellular adenosine mediates diverse anti-inflammatory, angiogenic, and other signaling effects via binding to adenosine receptors, and it also regulates cell proliferation and death via activation of the intrinsic signaling pathways. Given the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba785f63b08b3d5981c45ab01d650f48
https://doi.org/10.1158/1541-7786.c.6539982.v1
https://doi.org/10.1158/1541-7786.c.6539982.v1
Autor:
Kenneth A. Jacobson, Mirko Scortichini, Riham M. Idris, Susanne Moschütz, Antje Keim, Veronica A. Salmaso, Clemens Dobelmann, Paola A. Oliva, Karolina Losenkova, Heikki Irjala, Samuli Vaittinen, Jouko Sandholm, Gennady G. Yegutkin, Norbert Sträter, Anna Junker, Christa E. Müller
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1ffef5b7605e42873b5327ca2ba53d
https://doi.org/10.1096/fasebj.2022.36.s1.r3981
https://doi.org/10.1096/fasebj.2022.36.s1.r3981
Autor:
Karolina Losenkova, Riham M. Idris, Yulu Wang, Laura Schäkel, Christian Renn, Constanze C. Schmies, Georg Rolshoven, Gennady G. Yegutkin, Francesca Garofano, Christa E. Müller, Haneen Al-Hroub, Ingo G.H. Schmidt-Wolf, Herbert Zimmermann
Publikováno v:
ACS Med Chem Lett
[Image: see text] Ecto-5′-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a9bf386645b298c5f684bf50b8f276
https://doi.org/10.1021/acsmedchemlett.0c00391
https://doi.org/10.1021/acsmedchemlett.0c00391
Autor:
Karolina Losenkova, Akira Takeda, Symantas Ragauskas, Marc Cerrada-Gimenez, Maria Vähätupa, Simon Kaja, Marius L. Paul, Constanze C. Schmies, Georg Rolshoven, Christa E. Müller, Jouko Sandholm, Sirpa Jalkanen, Giedrius Kalesnykas, Gennady G. Yegutkin
Publikováno v:
Cellular and Molecular Life Sciences. 79
ATP and adenosine have emerged as important signaling molecules involved in vascular remodeling, retinal functioning and neurovascular coupling in the mammalian eye. However, little is known about the regulatory mechanisms of purinergic signaling in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9e47fff3564e83ba322c099857abf2
https://doi.org/10.1007/s00018-022-04187-4
https://doi.org/10.1007/s00018-022-04187-4
Autor:
Mirko Scortichini, Riham Mohammed Idris, Susanne Moschütz, Antje Keim, Veronica Salmaso, Clemens Dobelmann, Paola Oliva, Karolina Losenkova, Heikki Irjala, Samuli Vaittinen, Jouko Sandholm, Gennady G. Yegutkin, Norbert Sträter, Anna Junker, Christa E. Müller, Kenneth A. Jacobson
Publikováno v:
J Med Chem
We recently reported N(4)-substituted 3-methylcytidine-5′-α,β-methylenediphosphates as CD73 inhibitors, potentially useful in cancer immunotherapy. We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09bf77533e645ca0044d06f97aaa505
http://hdl.handle.net/11577/3459805
http://hdl.handle.net/11577/3459805