Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Gennady A. Belitsky"'
Autor:
Timur I. Fetisov, Sofya A. Khazanova, Polina A. Shtompel, Ekaterina S. Trapeznikova, Victoria Y. Zinovieva, Valeria I. Marshall, Anastasia A. Lovenger, Dmitriy V. Rogozhin, Tararykova A. Anastasia, Beniamin Yu. Bokhyan, Gennady A. Belitsky, Marianna G. Yakubovskaya, Kirill I. Kirsanov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12292 (2023)
Treatment of highly malignant soft tissue sarcomas (STSs) requires multicomponent therapy including surgery, radiotherapy, and chemotherapy. Despite the advancements in targeted cancer therapies, cytostatic drug combinations remain the gold standard
Externí odkaz:
https://doaj.org/article/1870bd7cd0394c30998b8f4013897ad0
Autor:
Timur I. Fetisov, Anna A. Borunova, Alina S. Antipova, Elena E. Antoshina, Lubov S. Trukhanova, Tatyana G. Gorkova, Svetlana N. Zuevskaya, Alexei Maslov, Katerina Gurova, Andrei Gudkov, Ekaterina A. Lesovaya, Gennady A. Belitsky, Marianna G. Yakubovskaya, Kirill I. Kirsanov
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 230 (2023)
The anticancer activity of Curaxin CBL0137, a DNA-binding small molecule with chromatin remodulating effect, has been demonstrated in different cancers. Herein, a comparative evaluation of CBL0137 activity was performed in respect to acute myeloid le
Externí odkaz:
https://doaj.org/article/2f23be8ffe4d44358670b9b012cc3676
Autor:
Roman G. Zenkov, Kirill I. Kirsanov, Anna M. Ogloblina, Olga A. Vlasova, Denis S. Naberezhnov, Natalia Y. Karpechenko, Timur I. Fetisov, Ekaterina A. Lesovaya, Gennady A. Belitsky, Nina G. Dolinnaya, Marianna G. Yakubovskaya
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9209 (2022)
Guanine-rich DNA sequences tending to adopt noncanonical G-quadruplex (G4) structures are over-represented in promoter regions of oncogenes. Ligands recognizing G4 were shown to stabilize these DNA structures and drive their formation regulating expr
Externí odkaz:
https://doaj.org/article/05a632071b7f4dbd854e17254fbf3481
Autor:
Ekaterina M. Zhidkova, Evgeniya S. Lylova, Diana D. Grigoreva, Kirill I. Kirsanov, Alena V. Osipova, Evgeny P. Kulikov, Sergey A. Mertsalov, Gennady A. Belitsky, Irina Budunova, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9686 (2022)
Regulated in Development and DNA Damage Response 1 (REDD1)/DNA Damage-Induced Transcript 4 (DDIT4) is an immediate early response gene activated by different stress conditions, including growth factor depletion, hypoxia, DNA damage, and stress hormon
Externí odkaz:
https://doaj.org/article/ddb441607d554eeda42fdb13e5f4fbbb
Autor:
Natalia I. Moiseeva, Lidia A. Laletina, Timur I. Fetisov, Leyla F. Makhmudova, Angelika E. Manikaylo, Liliya Y. Fomina, Denis A. Burov, Ekaterina A. Lesovaya, Beniamin Y. Bokhyan, Victoria Y. Zinovieva, Alice S. Vilkova, Larisa V. Mekheda, Nikolay A. Kozlov, Alexander M. Scherbakov, Evgeny M. Kirilin, Gennady A. Belitsky, Marianna G. Yakubovskaya, Kirill I. Kirsanov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3183 (2022)
Chemotherapy of soft tissue sarcomas (STS) is restricted by low chemosensitivity and multiple drug resistance (MDR). The purpose of our study was the analysis of MDR mechanism in different types of STS. We assessed the expression of ABC-transporters,
Externí odkaz:
https://doaj.org/article/1319413b6ff44b868de304e03be23b79
Autor:
Kirill I. Kirsanov, Ekaterina A. Lesovaya, Timur I. Fetisov, Beniamin Yu Bokhyan, Gennady A. Belitsky, Marianna G. Yakubovskaya
Publikováno v:
Sarcoma, Vol 2020 (2020)
Soft tissue sarcomas (STS) are a highly heterogeneous group of cancers of mesenchymal origin with diverse morphologies and clinical behaviors. While surgical resection is the standard treatment for primary STS, advanced and metastatic STS patients ar
Externí odkaz:
https://doaj.org/article/ad3667d4ce6a42ae94070fad485d78b3
Autor:
Roman G. Zenkov, Olga A. Vlasova, Varvara P. Maksimova, Timur I. Fetisov, Natalia Y. Karpechenko, Lidiya V. Ektova, Vera A. Eremina, Valeriia G. Popova, Olga G. Usalka, Ekaterina A. Lesovaya, Gennady A. Belitsky, Marianna G. Yakubovskaya, Kirill I. Kirsanov
Publikováno v:
Molecules, Vol 26, Iss 23, p 7329 (2021)
Novel indolocarbazole derivatives named LCS were synthesized by our research group. Two of them were selected as the most active anticancer agents in vivo. We studied the mechanisms of anticancer activity in accordance with the previously described e
Externí odkaz:
https://doaj.org/article/84e2607c91ea44b1b4fe81b35f92e38d
Autor:
Marianna G. Yakubovskaya, Katerina V. Gurova, Andrei V. Gudkov, Gennady A. Belitsky, Andrei A. Purmal, Andrey Leonov, Roman Ivanov, Elena Shipaeva, Ramiz Salimov, Daria Fleyshman, Alfiya Safina, Olga Morozova, Tatiana Gor'kova, Elena Antoshina, Lubov Trukhanova, Varvara Maksimova, Ekaterina A. Lesovaya, Timur Fetisov, Kirill Kirsanov
Chemoprevention is considered a valid approach to reduce the incidence of colorectal cancer, one of the most common malignancies worldwide. Here, we investigated the tumor-preventive activity of curaxin CBL0137. This compound represents a new class o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d9d0821b6b5cb8fb75aea668ab913b
https://doi.org/10.1158/1940-6207.c.6547412.v1
https://doi.org/10.1158/1940-6207.c.6547412.v1
Autor:
Marianna G. Yakubovskaya, Katerina V. Gurova, Andrei V. Gudkov, Gennady A. Belitsky, Andrei A. Purmal, Andrey Leonov, Roman Ivanov, Elena Shipaeva, Ramiz Salimov, Daria Fleyshman, Alfiya Safina, Olga Morozova, Tatiana Gor'kova, Elena Antoshina, Lubov Trukhanova, Varvara Maksimova, Ekaterina A. Lesovaya, Timur Fetisov, Kirill Kirsanov
Supplemental Table 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d647692b3c8f35584fd231862440ae77
https://doi.org/10.1158/1940-6207.22534220
https://doi.org/10.1158/1940-6207.22534220
Autor:
Evgeny M. Kirilin, Timur I. Fetisov, Natalia I. Moiseeva, Ekaterina A. Lesovaya, Lidia A. Laletina, Leyla F. Makhmudova, Angelika E. Manikaylo, Liliya Y. Fomina, Denis A. Burov, Beniamin Yu. Bokhyan, Victoria Y. Zinovieva, Alice S. Vilkova, Larisa V. Mekheda, Nikolay A. Kozlov, Alexander M. Scherbakov, Gennady A. Belitsky, Vytas Švedas, Kirill I. Kirsanov, Marianna G. Yakubovskaya
Publikováno v:
Cancers; Volume 14; Issue 7; Pages: 1796
Soft tissue sarcomas (STS) are heterogeneous cancers with more than 100 histological subtypes, different in molecular alterations, which make its personalized therapy very complex. Gold standard of chemotherapy for advanced STS includes combinations