Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gennady A. Babkin"'
Autor:
Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5). Primary screening in zebrafish (Danio reri
Externí odkaz:
https://doaj.org/article/76cf2f54874a4026980726e84e360222
Autor:
Anton V. Malyshev, Iuliia A. Sukhanova, Alexander S. Zlobin, Vasilina R. Gedzun, Vsevolod V. Pavshintsev, Ekaterina V. Vasileva, Arthur O. Zalevsky, Igor I. Doronin, Nikita A. Mitkin, Andrey V. Golovin, Maxim L. Lovat, Georgy I. Kovalev, Yurii A. Zolotarev, Askar R. Kuchumov, Gennady A. Babkin, Bernhard Luscher
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The aim of the study was to develop better anxiolytics and antidepressants. We focused on GABAA receptors and the α2δ auxiliary subunit of V-gated Ca2+ channels as putative targets because they are established as mediators of efficacious anxiolytic
Externí odkaz:
https://doaj.org/article/744533a44c374b5489533f40fc433b89
Autor:
Nikita A. Mitkin, Vsevolod V. Pavshintcev, Iuliia A. Sukhanova, Igor I. Doronin, Gennady A. Babkin, Marianna Sadagurski, Anton V. Malyshev
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2088 (2022)
The aim of this study was to develop a novel peptide potentially applicable for the treatment of metabolic conditions, such as obesity and type 2 diabetes (T2D). We identified CHM-273S from the list of peptides from milk hydrolysate obtained by HPLC/
Externí odkaz:
https://doaj.org/article/ef9a64e452c94d6aac004a5c4486fb75
Autor:
Anton V. Malyshev, Iuliia A. Sukhanova, Valeria M. Ushakova, Yana A. Zorkina, Olga V. Abramova, Anna Y. Morozova, Eugene A. Zubkov, Nikita A. Mitkin, Vsevolod V. Pavshintsev, Igor I. Doronin, Vasilina R. Gedzun, Gennady A. Babkin, Sergio A. Sanchez, Miah D. Baker, Colin N. Haile
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 462 (2022)
We have previously described the LCGA-17 peptide as a novel anxiolytic and antidepressant candidate that acts through the α2δ VGCC (voltage-gated calcium channel) subunit with putative synergism with GABA-A receptors. The current study tested the p
Externí odkaz:
https://doaj.org/article/eba1a1865ee04e8eb42573053d2d6eb5
Autor:
Arthur O. Zalevsky, Alexander S. Zlobin, Vasilina R. Gedzun, Roman V. Reshetnikov, Maxim L. Lovat, Anton V. Malyshev, Igor I. Doronin, Gennady A. Babkin, Andrey V. Golovin
Publikováno v:
Molecules, Vol 24, Iss 2, p 277 (2019)
Peptides are promising drug candidates due to high specificity and standout safety. Identification of bioactive peptides de novo using molecular docking is a widely used approach. However, current scoring functions are poorly optimized for peptide li
Externí odkaz:
https://doaj.org/article/0547a369577e40568d69c725d8210959
Autor:
Alexander Zlobin, Roman V. Reshetnikov, Vasilina R. Gedzun, Maxim L. Lovat, Andrey V. Golovin, Arthur O. Zalevsky, Anton V. Malyshev, Gennady A. Babkin, Igor Doronin
Publikováno v:
Molecules
Molecules, Vol 24, Iss 2, p 277 (2019)
Molecules, Vol 24, Iss 2, p 277 (2019)
Peptides are promising drug candidates due to high specificity and standout safety. Identification of bioactive peptides de novo using molecular docking is a widely used approach. However, current scoring functions are poorly optimized for peptide li