Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Genna M. Luciani"'
Autor:
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102282- (2022)
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency
Externí odkaz:
https://doaj.org/article/8c9174ed85e342749dbc2bfff8c4fb40
Autor:
Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selecti
Externí odkaz:
https://doaj.org/article/38d967925aeb49498c5e1209a2983c26
Autor:
Evelyne Lima-Fernandes, Alex Murison, Tiago da Silva Medina, Yadong Wang, Anqi Ma, Cherry Leung, Genna M. Luciani, Jennifer Haynes, Aaron Pollett, Constanze Zeller, Shili Duan, Antonija Kreso, Dalia Barsyte-Lovejoy, Bradly G. Wouters, Jian Jin, Daniel D. De Carvalho, Mathieu Lupien, Cheryl H. Arrowsmith, Catherine A. O’Brien
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiatin
Externí odkaz:
https://doaj.org/article/03a72eb189654119bb1c127366a2d06f
Autor:
Andrew R. Burns, Genna M. Luciani, Gabriel Musso, Rachel Bagg, May Yeo, Yuqian Zhang, Luckshi Rajendran, John Glavin, Robert Hunter, Elizabeth Redman, Susan Stasiuk, Michael Schertzberg, G. Angus McQuibban, Conor R. Caffrey, Sean R. Cutler, Mike Tyers, Guri Giaever, Corey Nislow, Andy G. Fraser, Calum A. MacRae, John Gilleard, Peter J. Roy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f372221257b04ca99777a3b815bb1dd0
Autor:
Corey Nislow, Genna M. Luciani, Sean R. Cutler, Yuqian Zhang, G. Angus McQuibban, Peter J. Roy, John Glavin, Mike Tyers, Guri Giaever, Conor R. Caffrey, Luckshi Rajendran, Gabriel Musso, Rachel Bagg, Andrew G. Fraser, John S. Gilleard, Andrew R. Burns, Michael R Schertzberg, Elizabeth Redman, May Yeo, Susan Stasiuk, Calum A. MacRae, Robert Hunter
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Parasitic nematodes infect one quarter of the world's population and impact all humans through widespread infection of crops and livestock. Resistance to current anthelmintics has prompted the search for new drugs. Traditional screens that rely on pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151897f9c89d907a8f6c870fb4269069
https://pubmed.ncbi.nlm.nih.gov/26108372
https://pubmed.ncbi.nlm.nih.gov/26108372
Autor:
Dalia Barsyte-Lovejoy, Bradly G. Wouters, Jian Jin, Jennifer Haynes, Antonija Kreso, Aaron Pollett, Anqi Ma, Catherine A. O’Brien, Cherry Leung, Evelyne Lima-Fernandes, Daniel D. De Carvalho, Genna M. Luciani, Yadong Wang, Shili Duan, Mathieu Lupien, Constanze Zeller, Tiago Medina, Alex Murison, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
In embryonic stem cells, promoters of key lineage-specific differentiation genes are found in a bivalent state, having both activating H3K4me3 and repressive H3K27me3 histone marks, making them poised for transcription upon loss of H3K27me3. Whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89b1b5c6d98bed6d275d1a675c7b977
https://doi.org/10.1038/s41467-019-09309-4
https://doi.org/10.1038/s41467-019-09309-4
Autor:
Tiziana Bonaldi, Cheryl M. Koh, Cheryl H. Arrowsmith, Christine Thompson, Heike Wollmann, Bas J. Wouters, Luca Pignata, Jia Yi Fong, Magdalena M. Szewczyk, Ari Melnick, Dalia Barsyte-Lovejoy, Daniele Musiani, Cheng Mun Wun, Alex Penson, Pierre-Alexis Goy, Jian Jin, Eirini P. Papapetrou, Mark D. Minden, Enrico Massignani, Genna M. Luciani, Omar Abdel-Wahab, Olena Barbash, Ernesto Guccione, Ruud Delwel, Diana Hp. Low, Michelle Ki, Alexander Rialdi, Kimihito Cojin Kawabata, Andriana G. Kotini, Timothy K. Hart, Megan C. Schwarz, Slim Mzoughi, Yudao Shen, Stanley Chun-Wei Lee
Publikováno v:
Cancer Cell, 36(2), 194-+. Cell Press
Cancer Cell
Cancer Cell
Cancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur in leukemias, as well as in a variety of solid tumors, and confer dependence on wild-type splicing. These observations have led to clinical efforts to directly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abc1c9ad1c9c46107e079dc43598e0c
https://pure.eur.nl/en/publications/4ea6f5b5-7be9-43d4-bebe-69e3c9d77205
https://pure.eur.nl/en/publications/4ea6f5b5-7be9-43d4-bebe-69e3c9d77205
Autor:
David Dilworth, Lihua Xie, Anne Tierens, Dalia Barsyte-Lovejoy, Yoni Moskovitz, Cheryl H. Arrowsmith, Alex Murison, Magdalena M. Szewczyk, Amanda Mitchell, Mathieu Lupien, John E. Dick, Mark D. Minden, Liran I. Shlush, Genna M. Luciani
Publikováno v:
Experimental hematology. 69
Acute myeloid leukemia (AML) is a complex, heterogeneous disease with variable outcomes following curative intent chemotherapy. AML with inv(3) is a genetic subgroup characterized by a very low response rate to current induction type chemotherapy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c25d41b911c116c34d60182588f140
https://pubmed.ncbi.nlm.nih.gov/30352278
https://pubmed.ncbi.nlm.nih.gov/30352278
Autor:
Andrew G. Fraser, Genna M. Luciani, Andrew R. Burns, Michael R Schertzberg, Peter J. Roy, May Yeo, Rachel Bagg
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005502 (2017)
PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005502 (2017)
Parasitic nematodes negatively impact human and animal health worldwide. The market withdrawal of nematicidal agents due to unfavourable toxicities has limited the available treatment options. In principle, co-administering nematicides at lower doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63558b0394d070be96cafd8306585e7
http://europepmc.org/articles/PMC5393889
http://europepmc.org/articles/PMC5393889
Autor:
Peter J. Roy, Kriti Arora, Malene L. Urbanus, Andrew R. Burns, Genna M. Luciani, Guri Giaever, Michael Proctor, Hao Wang, Corey Nislow, Carolyn L. Cummins, Lawrence E. Heisler, Mitchell K. L. Han, Gary D. Bader, Robert P. St.Onge, Terry Roemer, Iain M. Wallace
Publikováno v:
Chemistry & Biology. 18:1273-1283
SummaryPreselection of compounds that are more likely to induce a phenotype can increase the efficiency and reduce the costs for model organism screening. To identify such molecules, we screened ∼81,000 compounds in Saccharomyces cerevisiae and ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd69eec461d22b8315a2fe5831f031
https://doi.org/10.1016/j.chembiol.2011.07.018
https://doi.org/10.1016/j.chembiol.2011.07.018