Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Genki Minegishi"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 3, Pp n/a-n/a (2024)
Abstract Human cytochrome P450 3A4 (CYP3A4) is a drug‐metabolizing enzyme that is abundantly expressed in the liver and intestine. It is an important issue whether compounds of interest affect the expression of CYP3A4 because more than 30% of comme
Externí odkaz:
https://doaj.org/article/55c7f3693968404f9bc37d5fad77bfc4
Autor:
Kaoru Kobayashi, Genki Minegishi, Nina Kuriyama, Atsushi Miyajima, Satoshi Abe, Kanako Kazuki, Yasuhiro Kazuki
Publikováno v:
Drug Metabolism and Disposition. 51:174-182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::241e76f350325bd27b153b92700594a8
https://doi.org/10.1124/dmd.122.001087
https://doi.org/10.1124/dmd.122.001087
Autor:
Yuki, Yamasaki, Takashi, Moriwaki, Seiryo, Ogata, Shingo, Ito, Sumio, Ohtsuki, Genki, Minegishi, Satoshi, Abe, Yumi, Ohta, Kanako, Kazuki, Kaoru, Kobayashi, Yasuhiro, Kazuki
Publikováno v:
Pharmacogenetics and Genomics. 32:288-292
P-glycoprotein, the encoded product of the MDR1 / ABCB1 gene in humans, is expressed in numerous tissues including brain capillary endothelial cells and restricts the distribution of xenobiotics into the brain as an efflux pump. Although a large numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba08a6ba9a55e81e476473c7b71df0b
https://doi.org/10.1097/fpc.0000000000000481
https://doi.org/10.1097/fpc.0000000000000481
Autor:
Sakie Katsumura, Nadeem Siddiqui, Michael Rock Goldsmith, Jaime H. Cheah, Teppei Fujikawa, Genki Minegishi, Atsushi Yamagata, Yukako Yabuki, Kaoru Kobayashi, Mikako Shirouzu, Takeshi Inagaki, Tim H.-M. Huang, Nicolas Musi, Ivan Topisirovic, Ola Larsson, Masahiro Morita
Publikováno v:
Cell Metab
Hepatokines, secretory proteins from the liver, mediate inter-organ communication to maintain a metabolic balance between food intake and energy expenditure. However, molecular mechanisms by which hepatokine levels are rapidly adjusted following stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970244de0bcf0990090b1b20bf466cf4
https://pubmed.ncbi.nlm.nih.gov/35385705
https://pubmed.ncbi.nlm.nih.gov/35385705
Autor:
Hidetaka Akita, Kaoru Kobayashi, Genki Minegishi, Yasuhiro Kazuki, Atsushi Miyajima, Shin-Ichiro Nitta
It is important to predict drug-drug interactions via inhibition of intestinal cytochrome P450 3A (CYP3A) which is a determinant of bioavailability of orally administered CYP3A substrates. However, inhibitory effects of macrolide antibiotics on CYP3A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d8c6cc2495735aadd1a7d0b26ec573
Autor:
Kaoru Kobayashi, Jiro Kuze, Satoshi Abe, Satoshi Kitajima, Shoko Takehara, Genki Minegishi, Jun Kanno, Yasuhiro Kazuki, Mitsuo Oshimura, Takushi Yamamoto, Katsuhide Igarashi
Publikováno v:
Molecular pharmacology. 96(5)
Induction of cytochrome P450 enzyme 3A (CYP3A) in response to pregnane X receptor (PXR) activators shows species-specific differences. To study the induction of human CYP3A in response to human PXR activators, we generated a double-humanized mouse mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed11dc1248f8204596aa875f583c599e
https://pubmed.ncbi.nlm.nih.gov/31455676
https://pubmed.ncbi.nlm.nih.gov/31455676
Autor:
Shoko Takehara, Kaoru Kobayashi, Kanako Kazuki, Fuka Okuya, Sumio Ohtsuki, Yuki Yamasaki, Genki Minegishi, Satoshi Abe, Kan Chiba, Hidetaka Akita, Yasuhiro Kazuki, Mitsuo Oshimura, Seiryo Ogata, Naoyo Kajitani, Tatsuki Uemura, Shingo Ito
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(11)
P-glycoprotein (P-gp), encoded by the MDR1 gene in humans and by the Mdr1a/1b genes in rodents, is expressed in numerous tissues and performs as an efflux pump to limit the distribution and absorption of many drugs. Owing to species differences of P-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5b7b5568f09f527112e1b94827704e
https://pubmed.ncbi.nlm.nih.gov/29777024
https://pubmed.ncbi.nlm.nih.gov/29777024