Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Genji, Imokawa"'
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 548 (2023)
Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epide
Externí odkaz:
https://doaj.org/article/9f6319002d2a4f8ba1803831e256c094
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248150 (2021)
β-Sitosterol 3-O-d-glucoside (BSG) is known to act as an agonist by binding to estrogen receptors, and estrogen has been reported to enhance the activity of β-glucocerebrosidase, an epidermal ceramide metabolizing enzyme. In this study, we determin
Externí odkaz:
https://doaj.org/article/a91ab09fa3224183b9491c9536893eb5
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205061 (2018)
The activation of peroxisomeproliferator-activated receptor (PPAR) α can stimulate the expression of ceramide-related enzymes, and a major component of strawberry seed extract (SSE) tiliroside enhances the expression of PPARα. We determined whether
Externí odkaz:
https://doaj.org/article/8a947795e60e471994f79d9630907d0e
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13362
Because ceramide-like lipo-amino acid cholesteryl derivatives can exert a bound water-holding function due to their lamellae-forming properties, in this study, we determined if topical application of those derivatives to atopic dry skin would elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c66993d94b1f7664fd57eb4aebff7
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161580 (2016)
We recently reported that the over-expression of skin fibroblast-derived neutral endopeptidase (NEP) plays a pivotal role in impairing the three-dimensional architecture of dermal elastic fibers during the biological mechanism of ultraviolet (UV)-ind
Externí odkaz:
https://doaj.org/article/dcff2a692c32490996f3a0c230de23b0
Publikováno v:
J Biol Chem
Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that critically supports the physicochemical and mechanical properties of the skin. Here, we demonstrate that mycosporine-like amino acids (MAAs), which typically function as UV-absorbing c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac941d6924ebd6af498b75ae829f2161
https://doi.org/10.1074/jbc.ra119.011139
https://doi.org/10.1074/jbc.ra119.011139
Autor:
Genji Imokawa
Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that is physiologically enriched in the dermis and critically supports the physicochemical and mechanical properties of the skin. Little is known about the cellular mechanism(s) underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4ce9846875f8cca27f65c262e21e82
https://doi.org/10.9734/bpi/mono/978-93-5547-382-0
https://doi.org/10.9734/bpi/mono/978-93-5547-382-0
Autor:
Hideki Tagashira, Aki Miyamoto, Sei-Ichi Kitamura, Masahito Tsubata, Kazuya Yamaguchi, Kinya Takagaki, Genji Imokawa
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128678 (2015)
Melanogenesis is the physiological process by which melanin is synthesized to protect the skin from UV damage. While paracrine interactions between keratinocytes and melanocytes are crucial for regulating epidermal pigmentation, the endothelin (EDN)-
Externí odkaz:
https://doaj.org/article/a9cd1f0630d64b32875cc27a0b0a884e
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136311 (2015)
The influence of ultraviolet B (UVB) radiation on transglutaminase 1 (TGase 1), a major factor that regulates skin keratinization, has not been sufficiently characterized especially at the gene or protein level. Thus, we determined whether UVB affect
Externí odkaz:
https://doaj.org/article/b01709e219714dbcb8fce26c62d6dfeb
Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis
Autor:
Reiko Okamoto, Junko Arikawa, Mutsumi Ishibashi, Makoto Kawashima, Yutaka Takagi, Genji Imokawa
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 1, Pp 93-102 (2003)
To clarify the functional relevance of sphingomyelin (100) deacylase to the ceramide deficiency seen in atopic dermatitis (AD), we developed a new highly sensitive method and measured the metabolic intermediate sphingosylphosphorylcholine (SPC) that
Externí odkaz:
https://doaj.org/article/13377cc7fe094fac984c9b7cff0819a8