Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gengyang, Yuan"'
Autor:
Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, Changning Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1204-1215 (2019)
The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays a major role in various pathological conditions in the central nervous system (CNS), implicated in several neuropsychiatric disorders. Imaging of σ1R in the brain using positr
Externí odkaz:
https://doaj.org/article/6f8047a7f7314da6b2b69e01ff50ae50
Autor:
Gengyang, Yuan, Maeva, Dhaynaut, Nicolas J, Guehl, Sepideh, Afshar, Dalena, Huynh, Sung-Hyun, Moon, Suhasini M, Iyengar, Manish Kumar, Jain, Julie E, Pickett, Hye Jin, Kang, Mary Jo, Ondrechen, Georges, El Fakhri, Marc D, Normandin, Anna-Liisa, Brownell
Publikováno v:
Journal of medicinal chemistry. 65(14)
An array of triazolopyridines based on JNJ-46356479 (
Autor:
Georges El Fakhri, Normandin, Nicolas Guehl, Maeva Dhaynaut, Sepideh Afshar, Xiying Qu, Sung-Hyun Moon, Gengyang Yuan, Ramesh Neelamegam, Pekka Poutiainen, Anna-Lissa Brownell
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 43:296-308
Metabotropic glutamate receptor 2 (mGluR2) has been extensively studied for the treatment of various neurological and psychiatric disorders. Understanding of the mGluR2 function is pivotal in supporting the drug discovery targeting mGluR2. Herein, th
Autor:
Gengyang Yuan, Maeva Dhaynaut, Nicolas J. Guehl, Sepideh Afshar, Dalena Huynh, Sung-Hyun Moon, Suhasini M. Iyengar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Mary Jo Ondrechen, Georges El Fakhri, Marc D. Normandin, Anna-Liisa Brownell
Publikováno v:
Journal of Medicinal Chemistry. 65:9939-9954
Autor:
Gengyang, Yuan, Maeva, Dhaynaut, Yu, Lan, Nicolas J, Guehl, Dalena, Huynh, Suhasini M, Iyengar, Sepideh, Afshar, Manish Kumar, Jain, Julie E, Pickett, Hye Jin, Kang, Hao, Wang, Sung-Hyun, Moon, Mary Jo, Ondrechen, Changning, Wang, Timothy M, Shoup, Georges, El Fakhri, Marc D, Normandin, Anna-Liisa, Brownell
Publikováno v:
J Med Chem
Metabotropic glutamate receptor 2 (mGluR2) is a therapeutic target for several neuropsychiatric disorders. An mGluR2 function in etiology could be unveiled by positron emission tomography (PET). In this regard, 5-(2-fluoro-4-[(11)C]methoxyphenyl)-2,2
Autor:
Gengyang Yuan, Maeva Dhaynaut, Yu Lan, Nicolas J. Guehl, Dalena Huynh, Suhasini M. Iyengar, Sepideh Afshar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Hao Wang, Sung-Hyun Moon, Mary Jo Ondrechen, Changning Wang, Timothy M. Shoup, Georges El Fakhri, Marc D. Normandin, Anna-Liisa Brownell
Publikováno v:
Journal of Medicinal Chemistry. 65:2593-2609
Autor:
Sepideh, Afshar, Sevda, Lule, Gengyang, Yuan, Xiying, Qu, Chuzhi, Pan, Michael, Whalen, Anna-Liisa, Brownell, Maria, Mody
Publikováno v:
Translational Neuroscience. 13:80-92
Fragile X syndrome (FXS) is a monogenic disorder characterized by intellectual disability and behavioral challenges. It is caused by aberrant methylation of the fragile X mental retardation 1 (FMR1) gene. Given the failure of clinical trials in FXS a
Autor:
Gengyang Yuan, Darcy R. Tocci, Changning Wang, Stephen J. Haggarty, Zude Chen, Yan Liu, Hao Wang, Amelia G. Langan, Julia S. Zagaroli, Ping Bai, Robin Striar, Yu Lan, Sepideh Afshar, Debasis Patnaik
Publikováno v:
Journal of Medicinal Chemistry. 64:14745-14756
To better understand the role of bromodomain and extra-terminal domain (BET) proteins in epigenetic mechanisms, we developed a series of thienodiazepine-based derivatives and identified two compounds, 3a and 6a, as potent BET inhibitors. Further in v
Autor:
Hye Jin Kang, Maeva Dhaynaut, Nicolas Guehl, Zhaoda Zhang, Baohui Zheng, Anna-Liisa Brownell, Georges El Fakhri, Sung-Hyun Moon, Gengyang Yuan, Marc D. Normandin, Xiying Qu, Timothy M. Shoup, Sepideh Afshar
Publikováno v:
Molecular Imaging and Biology. 23:527-536
Metabotropic glutamate receptor 2 (mGluR2) has been implicated in various psychiatric and neurological disorders, such as schizophrenia and Alzheimer’s disease. We have previously developed [11C]7 as a PET radioligand for imaging mGluR2. Herein, [1
Autor:
Jing Yang, Huabiao Chen, Hao Wang, Ping Bai, Chongzhao Ran, Zude Chen, Yulong Xu, Robin Striar, Xiashuang Wang, Bo Xiang, Xiaoshuang Yang, Hong Li, Robert E. Koegel, Gengyang Yuan, Daniela R. Bernales, Qi Cao, Stephanie A. Fiedler, Changning Wang, Tao Li, Yu Yang
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 48:53-66
Castration-resistant prostate cancer (CRPC) is the most common cause of death in men. The effectiveness of HDAC inhibitors has been demonstrated by preclinical models, but not in clinical studies, probably due to the ineffectively accumulation of HDA