Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gengqian Cai"'
Autor:
Christine Barrett, Rachel B Jones, Sophie Gisbert, Ruth M. Tarzi, Alexandra Belson, Caroline O. S. Savage, Robert B Henderson, Lisa C. Willcocks, Gengqian Cai
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 35(4)
BackgroundImmunosuppressant drugs reduce proteinuria and anti-phospholipase A2 receptor autoantibodies (PLA2R-Ab) in primary membranous nephropathy (PMN) with varying success and associated toxicities. This study aimed to evaluate the effect of belim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02698958deb4e23c773f515c4c8d5fb2
https://pubmed.ncbi.nlm.nih.gov/31377779
https://pubmed.ncbi.nlm.nih.gov/31377779
Autor:
Lea Sarov-Blat, Michael J. Fossler, Adam McGeoch, Gengqian Cai, April M. Barbour, Joseph Cheriyan, Dennis L. Sprecher, Johann Graggaber, Jo Maison
Publikováno v:
British Journal of Clinical Pharmacology. 76:99-106
Aims The purpose of this study was to establish safety and tolerability of a single intravenous (IV) infusion of a p38 mitogen-activated protein kinase inhibitor, losmapimod, to obtain therapeutic levels rapidly for a potential acute coronary syndrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f907e5edbdfe800b5be9f6c6ba0458b
https://doi.org/10.1111/bcp.12063
https://doi.org/10.1111/bcp.12063
Autor:
Zahi A. Fayad, Bill Davis, Fergus V. Gleeson, John J. Lepore, L. Ceri Davies, Richard J.B. Wells, Joseph Cheriyan, David Collier, Maysoon Elkhawad, Michael S. Marber, Gengqian Cai, James H.F. Rudd, Ahmed Tawakol, Dennis L. Sprecher, Robert N. Willette, Robin P. Choudhury, Ian B. Wilkinson, Lea Sarov-Blat
Objectives This study sought to determine the effects of a p38 mitogen-activated protein kinase inhibitor, losmapimod, on vascular inflammation, by 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography imaging. Background The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dab84973675574b25953af150756af1
https://ora.ox.ac.uk/objects/uuid:57b6d166-c91d-40cd-a951-00994a26d455
https://ora.ox.ac.uk/objects/uuid:57b6d166-c91d-40cd-a951-00994a26d455
There are many clinical trials where longitudinal endpoints are used and the primary endpoint is quite often either based on the rate of change or change from baseline at a specific long-term follow-up time point. When such trials are monitored, it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307dff50d1a35fd7df6758c9564330f7
Autor:
Lea Sarov-Blat, Zahi A. Fayad, Paul M. Matthews, James H.F. Rudd, Parmanand Singh, Sarah P. Brannan, Michael E. Farkouh, Gengqian Cai, Ahmed Tawakol, Joseph Soffer, Bonnie C. Shaddinger, Esad Vucic, Sharath Subramanian, Elizabeth Tarka
Publikováno v:
Journal of the American College of Cardiology. 63:86-88
To the Editor: Previous reports have demonstrated that lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzymatic inflammatory biomarker, is associated with increased risk of cardiovascular events [(1)][1]. Lp-PLA2 mediates formation of bioactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2d52383946ec18453fffa00ef55537
https://doi.org/10.1016/j.jacc.2013.07.050
https://doi.org/10.1016/j.jacc.2013.07.050
Publikováno v:
The Journal of Clinical Pharmacology. 50:1142-1150
Studies to establish bioequivalence (BE) of a drug are important elements in support of drug applications. A typical BE study is conducted as a single dose, randomized, 2-period crossover design. For drugs with long half lives (≥ 48 hours) and eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828e027d56874097bb05a129ba146e06
https://doi.org/10.1177/0091270009355155
https://doi.org/10.1177/0091270009355155
Publikováno v:
Statistics in Biopharmaceutical Research. 2:165-174
In high-dimensional data analyses, such as in microarray experiments, the false discovery rate (FDR) has been widely used as an appropriate method to control false positive error rate, and some progress has been made on the issue of sample size calcu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b50fd7d759bf02cce7a9872ebbb514
https://doi.org/10.1198/sbr.2009.0058
https://doi.org/10.1198/sbr.2009.0058
Autor:
Gengqian Cai, Sanat K. Sarkar
Publikováno v:
Statistics & Probability Letters. 78:1362-1368
Considering independent test statistics, Simes’ critical values are modified and newer sets of critical values, each providing an exact control of the type I error rate, are obtained. These modifications, as simulations show, quite often yield more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::938355456c2991d4dfc52d1bcd44c361
https://doi.org/10.1016/j.spl.2007.12.018
https://doi.org/10.1016/j.spl.2007.12.018
Autor:
David M. Kleinman, Michael Fries, Diane E Balderson, Megan M. McLaughlin, Sheila B Young, John I. Wurzelmann, Gengqian Cai, Trupti Trivedi
Publikováno v:
BMC Ophthalmology
Background This objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geographic ulcer sub-types. Methods Da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b7600225112763757b8f5397ce1252
http://europepmc.org/articles/PMC4451880
http://europepmc.org/articles/PMC4451880
Autor:
Tianhui Zhou, Gengqian Cai
Publikováno v:
Statistics in Medicine. 31:1774-1776
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b9b297ca307ce5cc4d4924b91fadcd
https://doi.org/10.1002/sim.4445
https://doi.org/10.1002/sim.4445