Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Genghao Chen"'
Autor:
Genghao Chen, Ellen L. Shrock, Mamie Z. Li, Jonathan M. Spergel, Kari C. Nadeau, Jacqueline A. Pongracic, Dale T. Umetsu, Rima Rachid, Andrew J. MacGinnitie, Wanda Phipatanakul, Lynda Schneider, Hans C. Oettgen, Stephen J. Elledge
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100410- (2021)
Summary: Peanut allergy can result in life-threatening reactions and is a major public health concern. Oral immunotherapy (OIT) induces desensitization to food allergens through administration of increasing amounts of allergen. To dissect peanut-spec
Externí odkaz:
https://doaj.org/article/393b68bda2814b4c96490fe3b2cb72c0
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Recombinant adeno-associated viruses (AAVs) are among the most commonly used vehicles for in vivo gene delivery. However, their tropism is limited, and additionally their efficacy can be negatively affected by prevalence of neutralizing anti
Externí odkaz:
https://doaj.org/article/3e63cac820274427a3c7a71f9e4eb6ba
Autor:
Genghao Chen, Prashant Mali, Ashwin Ganesh, Yu Ru V. Shih, Dario Meluzzi, Atharv Worlikar, Shyni Varghese, Dhruva Katrekar
Publikováno v:
Nature methods, vol 16, iss 3
Nature methods
Nature methods
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c095da4f8ec9773531f525df8d6ecefd
https://doi.org/10.1038/s41592-019-0323-0
https://doi.org/10.1038/s41592-019-0323-0
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific reports, vol 8, iss 1
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports
Recombinant adeno-associated viruses (AAVs) are among the most commonly used vehicles for in vivo gene delivery. However, their tropism is limited, and additionally their efficacy can be negatively affected by prevalence of neutralizing antibodies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b073d022db8688a272edccf77fe1b66
https://doaj.org/article/3e63cac820274427a3c7a71f9e4eb6ba
https://doaj.org/article/3e63cac820274427a3c7a71f9e4eb6ba
Autor:
Hans C. Oettgen, Dale T. Umetsu, Stephen J. Elledge, Jacqueline A. Pongracic, Jonathan M. Spergel, Lynda C. Schneider, Genghao Chen, Kari C. Nadeau, Mamie Z. Li, Rima Rachid, Wanda Phipatanakul, Andrew J. MacGinnitie, Ellen Shrock
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100410-(2021)
Cell Reports Medicine
Cell Reports Medicine
Summary Peanut allergy can result in life-threatening reactions and is a major public health concern. Oral immunotherapy (OIT) induces desensitization to food allergens through administration of increasing amounts of allergen. To dissect peanut-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8302ae74312c4f528c354122c14cd4d
https://doi.org/10.1016/j.xcrm.2021.100410
https://doi.org/10.1016/j.xcrm.2021.100410
Autor:
Andrew Pla, Prashant Mali, Nathan Palmer, Ning Jiang, Mansun Law, Wei Leong Chew, Fernando Alemán, Ana M. Moreno, Genghao Chen
Publikováno v:
Nature biomedical engineering, vol 3, iss 10
Nature biomedical engineering
Nature biomedical engineering
Protein-based therapeutics can activate the adaptive immune system, leading to the production of neutralizing antibodies and the clearance of the treated cells mediated by cytotoxic T cells. Here, we show that the sequential use of immune-orthogonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441df79c2d1deaca8dff3b63471f0f1c
https://escholarship.org/uc/item/38x8w82w
https://escholarship.org/uc/item/38x8w82w
Publikováno v:
Biochemistry. 58(15)
Targeted transcriptome engineering, in contrast to genome engineering, offers a complementary and potentially tunable and reversible strategy for cellular engineering. In this regard, adenosine to inosine (A-to-I) RNA base editing was recently engine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154778a26c454e7f4c64f0247c0791c5
https://pubmed.ncbi.nlm.nih.gov/30943016
https://pubmed.ncbi.nlm.nih.gov/30943016
Autor:
A Pla, Mansun Law, Genghao Chen, Nathan Palmer, Ana M. Moreno, Wei Leong Chew, Fernando Alemán, Prashant Mali
A major hurdle in protein-based therapeutics is the interaction with the adaptive immune system, which can lead to neutralization by circulating antibodies and clearance of treated cells by cytotoxic T-lymphocytes. One method of circumventing these i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d512b6d4f65aa8b34d931c6b21014c3e
https://doi.org/10.1101/245985
https://doi.org/10.1101/245985
Autor:
Genghao Chen, Wei Leong Chew, Fernando Alemán, Nathan Palmer, Mansun Law, Ning Jiang, Andrew Pla, Ana M. Moreno, Prashant Mali
Publikováno v:
Nature Biomedical Engineering. 3:842-842
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1f97d94c3e61dc0b4bba394e3f7029
https://doi.org/10.1038/s41551-019-0456-6
https://doi.org/10.1038/s41551-019-0456-6