Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Genevieve Thon"'
Autor:
Jan Fabio Nickels, Maria Eduarda Della-Rosa, Iñigo Miguelez Goyeneche, Sebastian Jespersen Charlton, Kim Sneppen, Genevieve Thon
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110828- (2022)
Summary: Transcription factors can exert opposite effects depending on the chromosomal context. The fission yeast transcription factor Atf1 both activates numerous genes in response to stresses and mediates heterochromatic gene silencing in the matin
Externí odkaz:
https://doaj.org/article/83af020f44bd438d961a62ac8d8fa949
Autor:
Leonie Johanna Jahn, Bethany Mason, Peter Brøgger, Tea Toteva, Dennis Kim Nielsen, Genevieve Thon
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 2, Pp 477-489 (2018)
Chromatin structure regulates both genome expression and dynamics in eukaryotes, where large heterochromatic regions are epigenetically silenced through the methylation of histone H3K9, histone deacetylation, and the assembly of repressive complexes.
Externí odkaz:
https://doaj.org/article/bbfd252e2f7b49bf809788680a4ab4d4
Autor:
Maria M. Jørgensen, Babatunde Ekundayo, Mikel Zaratiegui, Karen Skriver, Geneviève Thon, Thomas Schalch
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract The mechanism by which specific protein-DNA complexes induce programmed replication fork stalling in the eukaryotic genome remains poorly understood. In order to shed light on this process we carried out structural investigations on the esse
Externí odkaz:
https://doaj.org/article/928c8bb1f12547a5aec8f2641195749b
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Chromosomes contain large heterochromatin domains. Here, the authors measure the kinetics of heterochromatin formation in fission yeast and show both global and local feedbacks by nucleosome-bound enzymes are important for formation and stability of
Externí odkaz:
https://doaj.org/article/8880659a3dfa477c9b75c47c49059d14
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007424 (2018)
Mating-type switching in Schizosaccharomyces pombe entails programmed gene conversion events regulated by DNA replication, heterochromatin, and the HP1-like chromodomain protein Swi6. The whole mechanism remains to be fully understood. Using a gene d
Externí odkaz:
https://doaj.org/article/4ff933ff21ee44a7a5e2d2f41e590cb9
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003762 (2013)
Mating-type switching in fission yeast results from gene conversions of the active mat1 locus by heterochromatic donors. mat1 is preferentially converted by mat2-P in M cells and by mat3-M in P cells. Here, we report that donor choice is governed by
Externí odkaz:
https://doaj.org/article/e509af0c255044b09a44722e83531786
Autor:
Julie Bonne Køhler, Maria Louise Mønster Jørgensen, Gabriele Beinoraité, Michael Thorsen, Geneviève Thon
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80442 (2013)
In eukaryotes many players in the DNA-damage response (DDR) catalyze protein sumoylation or ubiquitylation. Emphasis has been placed on how these modifications orchestrate the sequential recruitment of repair factors to sites of DNA damage or stalled
Externí odkaz:
https://doaj.org/article/f1b99d1b565e4c3eacb8058916c593d1
H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
Autor:
Klavs R Hansen, Idit Hazan, Sreenath Shanker, Stephen Watt, Janne Verhein-Hansen, Jürg Bähler, Robert A Martienssen, Janet F Partridge, Amikam Cohen, Geneviève Thon
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001268 (2011)
Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both m
Externí odkaz:
https://doaj.org/article/a670cdb460fd4b668806fc392be4176a