Characterizing the Causal Pathway From Childhood Adiposity to Right Heart Physiology and Pulmonary Circulation Using Lifecourse Mendelian Randomization

Autor: Genevieve M. Leyden, Helena Urquijo, Alun D. Hughes, George Davey Smith, Tom G. Richardson

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)

Background Observational epidemiological studies have reported an association between childhood adiposity and altered cardiac morphology and function in later life. However, whether this is due to a direct consequence of being overweight during child

Externí odkaz: https://doaj.org/article/7eb5f434dfea4d92a2430f011eea098d

Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study

Autor: Tom G Richardson, Genevieve M Leyden, George Davey Smith

Publikováno v: eLife, Vol 12 (2023)

Background: Findings from Mendelian randomization (MR) studies are conventionally interpreted as lifelong effects, which typically do not provide insight into the molecular mechanisms underlying the effect of an exposure on an outcome. In this study,

Externí odkaz: https://doaj.org/article/7f7d7a1d212447129340f2899aa4fefa

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.

Autor: Tom G Richardson, Genevieve M Leyden, Qin Wang, Joshua A Bell, Benjamin Elsworth, George Davey Smith, Michael V Holmes

Publikováno v: PLoS Biology, Vol 20, Iss 2, p e3001547 (2022)

Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets on the human metabolome. We firstly constructed genetic risk scores for 8 drug targets on t

Externí odkaz: https://doaj.org/article/1aada819a60a4b11b8b9795af6ae1b62

Harnessing tissue-specific genetic variation to dissect putative causal pathways between body mass index and cardiometabolic phenotypes

Autor: Genevieve M. Leyden, Chin Yang Shapland, George Davey Smith, Eleanor Sanderson, Michael P. Greenwood, David Murphy, Tom G. Richardson

Publikováno v: Am J Hum Genet

Body mass index (BMI) is a complex disease risk factor known to be influenced by genes acting via both metabolic pathways and appetite regulation. In this study, we aimed to gain insight into the phenotypic consequences of BMI-associated genetic vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3dec9933de57a2c84ab020f2c34d31b
https://doi.org/10.1016/j.ajhg.2021.12.013

Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation

Autor: Genevieve M. Leyden, Michael P. Greenwood, Valérie Gaborieau, Younghun Han, Christopher I. Amos, Paul Brennan, David Murphy, George Davey Smith, Tom G. Richardson

Publikováno v: Leyden, G, Greenwood, M P, Gaborieau, V, Han, Y, Amos, C I, Brennan, P, Murphy, D, Davey Smith, G & Richardson, T G 2022, ' Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation ', British Journal of Cancer . https://doi.org/10.1038/s41416-022-02060-6

Background Body mass index (BMI) is known to influence the risk of various site-specific cancers, however, dissecting which subcomponents of this heterogenous risk factor are predominantly responsible for driving disease effects has proven difficult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affe47622a15d2998c4534ade56588db
https://research-information.bris.ac.uk/en/publications/23cde668-e9ab-4555-9017-0251f03a6953