TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

Autor: Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams, TBVAC2020 Consortium, Warwick Britton, Jamie Triccas, Claudio Counoupas, Johan Grooten, Marie-Ange Demoitie, Marta Romano, Francoise Mascart, Peter Andersen, Claus Aagaard, Dennis Christensen, Morten Ruhwald, Thomas Lindenstrom, Pierre Charneau, Christophe Guilhot, Antonio Peixoto, Martine Gilleron, Camille Locht, Roland Brosch, Genevieve Inchauspe, Stephane Leung Theung Long, Stefan Kaufmann, January Weiner, Jeroen Maertzdorf, Natalie Neuwenhuizen, Max Bastian, Nadia Caccamo, Delia Goletti, Roberto Nisini, Sung Jae Shin, Hyejon Lee, Alex Sigal, Thomas Scriba, Gerhard Walzl, Andre Loxton, Robert Wilkinson, Pere-Joan Cardona, Cris Vilaplana, Carlos Martin, Dessi Marinova, Nacho Aguilo, Ruedi Aebersold, Etienne Caron, Daniel Pinschewer, Gennaro De Libero, Claire Anne Siegrist, Nicolas Collin, Christophe Barnier-Quer, Peter Sander, Frank Verreck, Tom Ottenhoff, Simone Joosten, Krista van Meijgaarden, Mariateresa Coppola, Annemieke Geluk, Yvonne Perrie, Marc Baird, Michael Levin, Hazel Dockrell, Steven Smith, Helen Fletcher, Gregory Bancroft, Ann Rawkins, Simon Clark, Iman Satti, Elena Stylianou, Martin Vordermeier, Philip Hogarth

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The p

Externí odkaz: https://doaj.org/article/c7965df9c6da40b7adb41882e3834949

Intravenous injection of a novel viral immunotherapy encoding human interleukin-7 in nonhuman primates is safe and increases absolute lymphocyte count

Autor: Charles-Antoine Coupet, Clarisse Dubois, Alexeï Evlachev, Nadine Kehrer, Marie Baldazza, Sam Hofman, Michel Vierboom, Perrine Martin, Geneviève Inchauspe

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 18, Iss 6 (2022)

Persistence of an immunosuppression, affecting both the innate and adaptive arms of the immune system, plays a role in sepsis patients’ morbidity and late mortality pointing to the need for broad and effective immune interventions. MVA-hIL-7-Fc is

Externí odkaz: https://doaj.org/article/34147fb2294e41a891bc167095ec9a0a

A novel virotherapy encoding human interleukin-7 improves ex vivo T lymphocyte functions in immunosuppressed patients with septic shock and critically ill COVID-19

Autor: Morgane Crausaz, Guillaume Monneret, Filippo Conti, Anne-Claire Lukaszewicz, Jean-Baptiste Marchand, Perrine Martin, Geneviève Inchauspé, Fabienne Venet

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

A majority of patients with sepsis surviving the first days in intensive care units (ICU) enter a state of immunosuppression contributing to their worsening. A novel virotherapy based on the non-propagative Modified Virus Ankara (MVA) expressing the

Externí odkaz: https://doaj.org/article/2659ad21530d401ca59aa08a63494f4c

Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates

Autor: Dong-Hun Lee, Genevieve Inchauspe, Marc Nasoff, Suzanne Zebedee, Masahiko Sugitani, Alfred M. Prince

Publikováno v: Proceedings of the National Academy of Sciences. 88:10292-10296

Genomic RNA from the human prototype strain H of the hepatitis C virus (HCV-H) has been molecularly cloned and sequenced. The HCV-H sequence reported consists of 9416 nucleotides including the 5' and 3' untranslated regions. HCV-H shows 96% amino aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69cecac346a173cd1e7bbebaf3e2800
https://doi.org/10.1073/pnas.88.22.10292

Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity

Autor: Christine S, Rollier, Glaucia, Paranhos-Baccala, Ernst J, Verschoor, Babs E, Verstrepen, Joost A R, Drexhage, Zahra, Fagrouch, Jean-Luc, Berland, Florence, Komurian-Pradel, Blandine, Duverger, Nourredine, Himoudi, Caroline, Staib, Marcus, Meyr, Mike, Whelan, Joseph A, Whelan, Victoria C, Adams, Victoria A, Adams, Esther, Larrea, José I, Riezu, Juan J, Lasarte, Juan José, Lasarte, Birke, Bartosch, Francois-L, Cosset, Willy J M, Spaan, Helmut M, Diepolder, Gerd R, Pape, Gerd, Sutter, Genevieve, Inchauspe, Jonathan L, Heeney

Publikováno v: Hepatology (Baltimore, Md.). 45(3)

UNLABELLED: Broad T cell and B cell responses to multiple HCV antigens are observed early in individuals who control or clear HCV infection. The prevailing hypothesis has been that similar immune responses induced by prophylactic immunization would r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9fb586902dbb42a89782793b50a559
http://ora.ox.ac.uk/objects/uuid:b763ddb7-1bd1-4ae2-a43e-3a480c7ea995