Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Genevieve Evin"'
Autor:
Amee J George, R.M.Damian Holsinger, Catriona A McLean, Katrina M Laughton, Konrad Beyreuther, Genevieve Evin, Colin L Masters, Qiao-Xin Li
Publikováno v:
Neurobiology of Disease, Vol 16, Iss 1, Pp 124-132 (2004)
Cholesterol is one of multiple factors, other than familial genetic mutations, that can influence amyloid-β peptide (Aβ) metabolism and accumulation in Alzheimer disease (AD). The effect of a high-cholesterol diet on amyloid precursor protein (APP)
Externí odkaz:
https://doaj.org/article/96e01e6ca6af429bbc91165eec660277
Autor:
Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61246 (2013)
BACE1 is responsible for β-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the production of amyloid β (Aβ) peptides. Previous reports, by us and others, have indicated that the levels of BACE1 protein
Externí odkaz:
https://doaj.org/article/2b897aca4f9544349be226e3a8651143
Autor:
Jiang-Li Tan, Qiao-Xin Li, Giuseppe D. Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/78760257e588435b955fbccbbbb5d155
Autor:
Genevieve Evin
Publikováno v:
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 30(3)
Alzheimer’s disease (AD) is the primary cause of dementia in the elderly. It remains incurable and poses a huge socio-economic challenge for developed countries with an aging population. AD manifests by progressive decline in cognitive functions an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180dcfbf8068aeb47b6d8f9cc023aaa8
https://pubmed.ncbi.nlm.nih.gov/27023706
https://pubmed.ncbi.nlm.nih.gov/27023706
Publikováno v:
Systems Biology of Alzheimer's Disease ISBN: 9781493926268
This chapter describes methods for establishing oxidative stress conditions that do not induce cell death in a neuronal cell culture model. We termed these conditions "mild oxidative stress," as opposed to "severe oxidative stress," which results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6328ce3a41af7d14aeaaff48a856eb8
https://doi.org/10.1007/978-1-4939-2627-5_4
https://doi.org/10.1007/978-1-4939-2627-5_4
Publikováno v:
Clinical Science (London, England : 1979)
Inhibition of GSL (glycosphingolipid) synthesis reduces Aβ (amyloid β-peptide) production in vitro. Previous studies indicate that GCS (glucosylceramide synthase) inhibitors modulate phosphorylation of ERK1/2 (extracellular-signal-regulated kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c24285a2061a30e90e2eb64b6b91e72
https://doi.org/10.1042/cs20110257
https://doi.org/10.1042/cs20110257
Autor:
Stefanie Rasche, Andrew F. Hill, Colin L. Masters, Catriona McLean, Shayne A. Bellingham, Genevieve Evin, Michael Ho, Claudia Santosa, Adel Barakat, Jiang-Li Tan
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 176-183 (2011)
BACE initiates the amyloidogenic processing of the amyloid precursor protein (APP) that results in the production of Aβ peptides associated with Alzheimer's disease (AD). Previous studies have indicated that BACE is elevated in the frontal cortex of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b612d1cd1f627ca7b37186587a3d4e16
https://doi.org/10.1016/j.nbd.2011.03.009
https://doi.org/10.1016/j.nbd.2011.03.009
Autor:
Genevieve Evin
Publikováno v:
Journal of Laboratory and Precision Medicine. 3:88-88
Alzheimer’s disease (AD) is the principal cause of dementia and impacts nearly 50 million people worldwide (1). This neurodegenerative disorder of the brain manifests as progressive loss of memory and decline in cognitive function, which may span t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e578a2a32f18f36650acd7e8ccc9c59
https://doi.org/10.21037/jlpm.2018.09.10
https://doi.org/10.21037/jlpm.2018.09.10
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1801:887-895
Previous studies suggest that membrane lipids may regulate proteolytic processing of the amyloid precursor protein (APP) to generate amyloid-beta peptide (Abeta). In the present study, we have assessed the capacity for a series of structurally relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cdd37e4fe43bb6cea8d13d4cee6ba2
https://doi.org/10.1016/j.bbalip.2010.05.012
https://doi.org/10.1016/j.bbalip.2010.05.012
Autor:
Victoria M. Perreau, Anthony R. White, Shayne A. Bellingham, Su San Mok, Henning Hermjakob, Sandra Orchard, Tiffany F. Cowie, Noel G. Faux, James A. Duce, Peter J. Crouch, Ya Hui Hung, Simon James, Qiao-Xin Li, Colin L. Masters, Roberto Cappai, Giuseppe D. Ciccotosto, Ashley I. Bush, Andrew F. Hill, Deborah J. Tew, Genevieve Evin, Paul A. Adlard
Publikováno v:
PROTEOMICS. 10:2377-2395
The primary constituent of the amyloid plaque, beta-amyloid (Abeta), is thought to be the causal "toxic moiety" of Alzheimer's disease. However, despite much work focused on both Abeta and its parent protein, amyloid precursor protein (APP), the func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813048f6ba1560537eb43470088f2367
https://doi.org/10.1002/pmic.200900773
https://doi.org/10.1002/pmic.200900773