Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Genevieve Daune"'
Publikováno v:
Pharmacology & Toxicology. 73:29-34
Mice and chicken were given 5-fluoromethylornithine (5FMOrn), a selective inactivator of ornithine aminotransferase (OAT) over extended periods of time. This treatment allowed us to maintain elevated concentrations of ornithine in all tissues. Since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab70e3cb9ee66a627b9fdc92dc9f00b3
https://doi.org/10.1111/j.1600-0773.1993.tb01953.x
https://doi.org/10.1111/j.1600-0773.1993.tb01953.x
Publikováno v:
Metabolic brain disease. 8(3)
The vertebrate brain has the machinery to transport arginine and ornithine, and to form within nerve endings from these amino acids glutamate and GABA, the major excitatory and inhibitory neurotransmitters. Ornithine aminotransferase is a key enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6763e90411d12cd8642402d3226f552
https://pubmed.ncbi.nlm.nih.gov/8272027
https://pubmed.ncbi.nlm.nih.gov/8272027
Publikováno v:
Biochemical Journal. 253:481-488
5-Fluoromethylornithine (5-FMOrn) is the first specific irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT) found. Single doses (greater than 10 mg/kg) of this compound inactivate OAT to a residual OAT-like activity. This activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c880ee3528e35be0199a25d6bf518ed1
https://doi.org/10.1042/bj2530481
https://doi.org/10.1042/bj2530481
Autor:
Donald M. Marcus, Norman Latov, Bart P. Hsi, Baiba K. Gillard, Jack Antel, Stanley Appel, Lanfranco Callegaro, Genevieve Daune, Baiba Gillard, Norman Latoy, Donald Marcus, Eduardo Nobile-Orazio, Alan Pestronk, Jacques Portoukalian, Richard Quarles, Edgar Salazar-Grueso, Larry Schneider, Michael Shy, Andreas Steck
Publikováno v:
Journal of neuroimmunology. 25(2-3)
Twelve laboratories from the United States, Canada, France, Italy and Switzerland participated in a workshop to compare assays used to measure anti-GM1 antibodies, and to discuss the clinical significance of these antibodies. A panel of test samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a152a181add6e19a9a1f17c52f20c9e
https://pubmed.ncbi.nlm.nih.gov/2584398
https://pubmed.ncbi.nlm.nih.gov/2584398
Publikováno v:
Neurochemistry international. 10(3)
In this work new methods for the determination of ornithine (Orn) and l-ornithine:2-oxoacid aminotransferase (OAT) activity are described. These methods were used to demonstrate linear interrelationships between brain GABA and Orn concentrations. Bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0c8c92682a66e1a9e1e4f6620afcea
https://pubmed.ncbi.nlm.nih.gov/20501111
https://pubmed.ncbi.nlm.nih.gov/20501111
Publikováno v:
Life sciences. 45(11)
5-Fluoromethylornithine (5FMorn) is a specific inactivator of L-ornithine:2-oxoacid aminotransferase (OAT). Inactivation of OAT causes the enhancement of L-ornithine (Orn) concentrations in all tissues. Intraperitoneal or oral administration of 10–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93061fc33328c0012c15e3d6f0b9a4e3
https://pubmed.ncbi.nlm.nih.gov/2507845
https://pubmed.ncbi.nlm.nih.gov/2507845