Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Genevieve Beauvais"'
Autor:
Zuchra Zakirova, Tomas Fanutza, Justine Bonet, Ben Readhead, Weijia Zhang, Zhengzi Yi, Genevieve Beauvais, Thomas P Zwaka, Laurie J Ozelius, Robert D Blitzer, Pedro Gonzalez-Alegre, Michelle E Ehrlich
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007169 (2018)
Dystonia is characterized by involuntary muscle contractions. Its many forms are genetically, phenotypically and etiologically diverse and it is unknown whether their pathogenesis converges on shared pathways. Mutations in THAP1 [THAP (Thanatos-assoc
Externí odkaz:
https://doaj.org/article/00a2e18113244167a08a3e1e5b91fac4
Autor:
Jean Lud Cadet, Christie Brannock, Bruce Ladenheim, Michael T. McCoy, Genevieve Beauvais, Amber B. Hodges, Elin Lehrmann, William H. Wood, Kevin G. Becker, Irina N. Krasnova
Publikováno v:
Dose-Response, Vol 9 (2011)
Methamphetamine (METH) is a toxic drug of abuse, which can cause significant decreases in the levels of monoamines in various brain regions. However, animals treated with progressively increasing doses of METH over several weeks are protected against
Externí odkaz:
https://doaj.org/article/da83c2a9f4c04ae484da2cb5d2d54f83
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28946 (2011)
Single large doses of methamphetamine (METH) cause endoplasmic reticulum (ER) stress and mitochondrial dysfunctions in rodent striata. The dopamine D(1) receptor appears to be involved in these METH-mediated stresses. The purpose of this study was to
Externí odkaz:
https://doaj.org/article/ee43f6e4c31a4660986ee037dc3443f3
Autor:
Jean Lud Cadet, Michael T McCoy, Ning Sheng Cai, Irina N Krasnova, Bruce Ladenheim, Genevieve Beauvais, Natascha Wilson, William Wood, Kevin G Becker, Amber B Hodges
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7812 (2009)
Methamphetamine (METH) is an illicit drug which is neurotoxic to the mammalian brain. Numerous studies have revealed significant decreases in dopamine and serotonin levels in the brains of animals exposed to moderate-to-large METH doses given within
Externí odkaz:
https://doaj.org/article/717031b9054640ed8ba66bda7e95c587
Autor:
Subramaniam Jayanthi, Michael T McCoy, Genevieve Beauvais, Bruce Ladenheim, Kristi Gilmore, William Wood, Kevin Becker, Jean Lud Cadet
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e6092 (2009)
Methamphetamine (METH) is an illicit toxic psychostimulant which is widely abused. Its toxic effects depend on the release of excessive levels of dopamine (DA) that activates striatal DA receptors. Inhibition of DA-mediated neurotransmission by the D
Externí odkaz:
https://doaj.org/article/5a49f44173c546e4bea36bf0e776e0df
Autor:
Brian S. Muntean, Michelle E. Ehrlich, Maria Daniela Cirnaru, Genevieve Beauvais, Garrett Otrimski, Chiara Melis, Pedro Gonzalez-Alegre, Jordi Creus-Muncunill, Kirill A. Martemyanov
Publikováno v:
Movement Disorders. 36:1147-1157
Background Similar to some monogenic forms of dystonia, levodopa-induced dyskinesia is a hyperkinetic movement disorder with abnormal nigrostriatal dopaminergic neurotransmission. Molecularly, it is characterized by hyper-induction of phosphorylation
Autor:
N. Charles Harata, Kevin A. Glenn, Pedro Gonzalez-Alegre, Jaime L. Watson, Genevieve Beauvais, Hsiang Wen, Hiroyuki Kawano, Nicole M. Bode, Michelle E. Ehrlich
Publikováno v:
The Journal of Neuroscience. 36:10245-10256
Dystonia type 1 (DYT1) is a dominantly inherited neurological disease caused by mutations inTOR1A, the gene encoding the endoplasmic reticulum (ER)-resident protein torsinA. Previous work mostly completed in cell-based systems suggests that mutant to
Autor:
Jyoti C. Patel, Pedro Gonzalez-Alegre, Michelle E. Ehrlich, Margaret E. Rice, Genevieve Beauvais, Rick J. Koch, Janine N. Martin, Ruth H. Walker
Publikováno v:
Neuroscience. 422
Dystonia is a disabling neurological syndrome characterized by abnormal movements and postures that result from intermittent or sustained involuntary muscle contractions; mutations of DYT1/TOR1A are the most common cause of childhood-onset, generaliz
Autor:
Genevieve Beauvais, Jaime L. Watson, Jose A. Aguirre, Michelle E. Ehrlich, Luis Tecedor, Pedro Gonzalez-Alegre
Publikováno v:
Brain research. 1706
DYT1 dystonia is a neurological disease caused by a dominant mutation that results in the loss of a glutamic acid in the endoplasmic reticulum-resident protein torsinA. Currently, treatments are symptomatic and only provide partial relief. Multiple r
Autor:
Zhengzi Yi, Pedro Gonzalez-Alegre, Justine Bonet, Thomas P. Zwaka, Zuchra Zakirova, Genevieve Beauvais, Laurie J. Ozelius, Ben Readhead, Robert D. Blitzer, Michelle E. Ehrlich, Tomas Fanutza, Weijia Zhang
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007169 (2018)
PLoS Genetics
PLoS Genetics
Dystonia is characterized by involuntary muscle contractions. Its many forms are genetically, phenotypically and etiologically diverse and it is unknown whether their pathogenesis converges on shared pathways. Mutations in THAP1 [THAP (Thanatos-assoc