Zobrazeno 1 - 10 of 49 pro vyhledávání: '"Genevieve, Nguyen"'
1
Akademický článek
(Pro)renin Receptor Inhibition Reduces Plasma Cholesterol and Triglycerides but Does Not Attenuate Atherosclerosis in Atherosclerotic Mice
Autor: Dien Ye, Xiaofei Yang, Liwei Ren, Hong S. Lu, Yuan Sun, Hui Lin, Lunbo Tan, Na Wang, Genevieve Nguyen, Michael Bader, Adam E. Mullick, A. H. Jan Danser, Alan Daugherty, Yizhou Jiang, Yidan Sun, Furong Li, Xifeng Lu
Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Objective: Elevated plasma cholesterol concentrations contributes to ischemic cardiovascular diseases. Recently, we showed that inhibiting hepatic (pro)renin receptor [(P)RR] attenuated diet-induced hypercholesterolemia and hypertriglyceridemia in lo
Externí odkaz: https://doaj.org/article/9afa4c3acbca4a4285530bd6e4d40d51
Zobrazit plný text záznamu
2
The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule
Autor: Anthony Rouselle, Arezoo Daryadel, Elena Popova, Michael Bader, Dominik N. Müller, Carsten A. Wagner, Gabin Sihn, Genevieve Nguyen, Marta Figueiredo
Publikováno v: Pflugers Archiv
The ATP6ap2 (Pro)renin receptor protein associates with H+-ATPases which regulate organellar, cellular, and systemic acid–base homeostasis. In the kidney, ATP6ap2 colocalizes with H+-ATPases in various cell types including the cells of the proximal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed5ba0c2a5d3ab4f0e9510762030e87
https://pubmed.ncbi.nlm.nih.gov/34228176
Zobrazit plný text záznamu
3
Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells
Autor: Sadayoshi Ito, Yoshikazu Muroya, Yusuke Ohsaki, Kazuhito Totsune, Ikuko Oba-Yabana, Takuo Hirose, Rémi Piedagnel, Chika Takahashi, Satoshi Kinugasa, Emiko Sato, Pierre Ronco, Takefumi Mori, Genevieve Nguyen
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-20940-x⟩
Scientific Reports, Nature Publishing Group, 2018, 8, pp.2648. ⟨10.1038/s41598-018-20940-x⟩
Scientific Reports, 2018, 8, pp.2648. ⟨10.1038/s41598-018-20940-x⟩
TGF-β1, which can cause renal tubular injury through a vacuolar-type H+-ATPase (V-ATPase)-mediated pathway, is induced by the glucose degradation product methylglyoxal to yield peritoneal injury and fibrosis. The present study investigated the roles
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243ed11f33eb30c797796070867acf0c
http://link.springer.com/article/10.1038/s41598-018-20940-x
Zobrazit plný text záznamu
4
Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells
Autor: Katrina J. Binger, Klemens Raile, Diana M. Willmes, Sabrina Geisberger, Michele Solimena, Matthew N. Poy, Martin Neukam, Sabrina Wurmsee, Ralf Dechend, Dmytro Puchkov, Andreas L. Birkenfeld, Dominik N. Müller, Genevieve Nguyen, Thomas Kurth, Sudhir Gopal Tattikota, Fatimunnisa Qadri
Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 116, 19983-19988 (2019)
Pancreatic β cells store insulin within secretory granules which undergo exocytosis upon elevation of blood glucose levels. Crinophagy and autophagy are instead responsible to deliver damaged or old granules to acidic lysosomes for intracellular deg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644d6cf759ccae84eed07fcbe2e66df0
https://europepmc.org/articles/PMC6778207/
Zobrazit plný text záznamu
5
The macula densa prorenin receptor is essential in renin release and blood pressure control
Autor: Elaine Tang, Anne Riquier-Brison, Ágnes Prókai, Karie Villanueva, Janos Peti-Peterdi, lldikó Toma, Bahram Nadim, Sarah L. Vargas, Elliott J. Meer, A.H. Jan Danser, Genevieve Nguyen, Ingrid M. Garrelds, Christopher Yih, Arnold Sipos, Georgina Gyarmati, Sujith Pendekanti, Jennifer C. M. Chen
Publikováno v: American Journal of Physiology-Renal Physiology, 315(3), F521-F534. American Physiological Society
The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS); however, recent work questioned their association. The present paper describes a functional link between the PRR and RAS in the renal juxtaglome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad21fba67fe9cf3b3cc6d1bc3c68d45
https://europepmc.org/articles/PMC6172576/
Zobrazit plný text záznamu
6
A functional (pro)renin receptor is expressed in human lymphocytes and monocytes
Autor: Mayuko Ishikawa, Sadayoshi Ito, Kazuhito Totsune, Hiroshi Sato, Kaori Narumi, Emiko Sato, Atsuhiro Ichihara, Takefumi Mori, Genevieve Nguyen, Kiyomi Kisu, Tomonori Ishii, Takuo Hirose
Publikováno v: American Journal of Physiology-Renal Physiology. 308:F487-F499
The renin-angiotensin system (RAS) is involved in inflammation. The signaling via the ANG II type 1 receptor in human lymphocytes and monocytes, which play key roles in pathophysiology of glomerulonephritis (GN), can enhance inflammation. However, th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b13df643edcc4ec427fcda83d41b381
https://doi.org/10.1152/ajprenal.00206.2014
Zobrazit plný text záznamu
8
Aliskiren accumulation in the kidney: no major role for binding to renin or prorenin
Autor: Rolf A.K. Stahl, Sascha Lange, Natalia Alenina, Anne-Roos S. Frenay, Harry van Goor, Genevieve Nguyen, Michael Bader, A.H. Jan Danser, Edzard Schwedhelm, Ulrich Wenzel, Christoph Fraune
Publikováno v: Journal of Hypertension, 31(4), 713-719. LIPPINCOTT WILLIAMS & WILKINS
Journal of Hypertension, 31(4), 713-719. Lippincott Williams & Wilkins
Background and objective: The antihypertensive effects of the direct renin inhibitor aliskiren last substantially longer after treatment withdrawal than expected based upon its plasma half-life. This may be attributable to drug accumulation in the ki
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb06dbe881ba7083e82fb2f9bb8d7971
https://doi.org/10.1097/HJH.0b013e32835e226b
Zobrazit plný text záznamu
9
AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease
Autor: Vera Jankowski, Nevena Divac, Ingrid M. Garrelds, Sascha Lange, Joachim Velden, Alexandra Hölzel, Christoph Fraune, Genevieve Nguyen, Ulrich Wenzel, Thomas Streichert, Anne-Roos Frenay, Christian Krebs, Edzard Schwedhelm, A.H. Jan Danser, Harry van Goor, Jana Baucke, Rolf A.K. Stahl
Publikováno v: American journal of physiology-Renal physiology, 303(7), F1037-F1048. AMER PHYSIOLOGICAL SOC
American Journal of Physiology-Renal Physiology, 303(7), F1037-F1048. American Physiological Society
Fraune C, Lange S, Krebs C, Holzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garrelds IM, Danser AH, Frenay A, van Goor H, Jankowski V, Stahl R, Nguyen G, Wenzel UO. AT(1) antagonism and renin inhibition in mice: pivotal role of tar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d46b0d5289242fc7975332db6e75a1
https://doi.org/10.1152/ajprenal.00672.2011
Zobrazit plný text záznamu
10
The Biology of the (Pro)Renin Receptor
Autor: Genevieve Nguyen, Dominik N. Müller
Publikováno v: Journal of the American Society of Nephrology. 21:18-23
The (pro)renin receptor (PRR) binds renin and prorenin, its proenzyme inactive form. Receptor-bound prorenin becomes enzymatically active and binding then activates the MAP kinases ERK1/2 and p38 pathways, leading to upregulation of profibrotic and c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8895589037aa5ef289a2749be7d33fc4
https://doi.org/10.1681/asn.2009030300
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje