Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Geneviève Lavoie"'
Autor:
Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract CDK12 is a transcriptional cyclin-dependent kinase (CDK) that interacts with cyclin K to regulate different aspects of gene expression. The CDK12-cyclin K complex phosphorylates several substrates, including RNA polymerase II (Pol II), and t
Externí odkaz:
https://doaj.org/article/29852213a0ff4f3898e31bb9afc0393f
Autor:
Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In patients with melanoma, increased RAS/mitogen-activated protein kinase (MAPK) pathway activity is known to drive chemotherapy resistance. Here, the authors identify CDK12 as a downstream effector of the RAS/MAPK pathway and therapeutic target whic
Externí odkaz:
https://doaj.org/article/875e347a38ed42f697dc3427cce904d4
Autor:
Emilie Heckel, Gael Cagnone, Tapan Agnihotri, Bertan Cakir, Ashim Das, Jin Sung Kim, Nicholas Kim, Geneviève Lavoie, Anu Situ, Sheetal Pundir, Ye Sun, Florian Wünnemann, Kerry A. Pierce, Courtney Dennis, Grant A. Mitchell, Sylvain Chemtob, Flavio A. Rezende, Gregor Andelfinger, Clary B. Clish, Philippe P. Roux, Przemyslaw Sapieha, Lois E.H. Smith, Jean-Sébastien Joyal
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of triglyceri
Externí odkaz:
https://doaj.org/article/2daa7b5d47564630a41d65386cd0a30f
Autor:
Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essent
Externí odkaz:
https://doaj.org/article/e0ea73c88dab4e7c804e408236956ef7
Autor:
Emilie L Cerezo, Thibault Houles, Oriane Lié, Marie-Kerguelen Sarthou, Charlotte Audoynaud, Geneviève Lavoie, Maral Halladjian, Sylvain Cantaloube, Carine Froment, Odile Burlet-Schiltz, Yves Henry, Philippe P Roux, Anthony K Henras, Yves Romeo
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009583 (2021)
Ribosome biogenesis lies at the nexus of various signaling pathways coordinating protein synthesis with cell growth and proliferation. This process is regulated by well-described transcriptional mechanisms, but a growing body of evidence indicates th
Externí odkaz:
https://doaj.org/article/d9e4b8bf8c4a485c8bce6800672ede2b
Autor:
Sami Nourreddine, Geneviève Lavoie, Justine Paradis, Khaled Ben El Kadhi, Antoine Méant, Léo Aubert, Benoit Grondin, Patrick Gendron, Benoit Chabot, Michel Bouvier, Sébastien Carreno, Philippe P. Roux
Publikováno v:
Cell Reports, Vol 31, Iss 7, Pp - (2020)
Summary: In human cells, the expression of ∼1,000 genes is modulated throughout the cell cycle. Although some of these genes are controlled by specific transcriptional programs, very little is known about their post-transcriptional regulation. Here
Externí odkaz:
https://doaj.org/article/9c3341b5819a4f42a2c8f5bed71f24df
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72468 (2013)
Galectin-7 was initially described as a marker of epithelial differentiation expressed in the stratified epithelium of various tissues. Like other members of the galectin family, its expression level is often significantly altered in cancer cells. In
Externí odkaz:
https://doaj.org/article/b2b718c42cc942d79fab06f87795f9cc
Autor:
Philippe P. Roux, Julie St-Pierre, Sang-Oh Yoon, Louis Gaboury, Benoit Grondin, Antoine Méant, Mathilde Savall, Sejeong Shin, Geneviève Lavoie, Simon-Pierre Gravel, Thibault Houles
RSK Inhibition in Melanoma Cells do not Affect Glycolytic Enzyme mRNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9ee6d0d2765c2ddb2673bb7d21c65b
https://doi.org/10.1158/0008-5472.22417386.v1
https://doi.org/10.1158/0008-5472.22417386.v1
Autor:
Philippe P. Roux, Julie St-Pierre, Sang-Oh Yoon, Louis Gaboury, Benoit Grondin, Antoine Méant, Mathilde Savall, Sejeong Shin, Geneviève Lavoie, Simon-Pierre Gravel, Thibault Houles
Metabolic reprogramming is a hallmark of cancer that includes increased glucose uptake and accelerated aerobic glycolysis. This phenotype is required to fulfill anabolic demands associated with aberrant cell proliferation and is often mediated by onc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289e5b3aab8b110d17b4847cb81cddf2
https://doi.org/10.1158/0008-5472.c.6509832.v1
https://doi.org/10.1158/0008-5472.c.6509832.v1
Autor:
Bernard Massie, Josephine Nalbantoglu, Anne-Marie Mes-Masson, Geneviève Lavoie, Simone P. Zehntner, Zafiro Koty, Jairo Jaime, Cara Jean Lau, Denis Bourbeau
Gene therapy is a promising approach for cancer treatment; however, efficacy of current vectors remains insufficient. To improve the success of suicide gene therapy, we constructed a replication-competent adenoviral vector that has its protease gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a22bace3f3b41bb85cdeb683005f794
https://doi.org/10.1158/0008-5472.c.6496322.v1
https://doi.org/10.1158/0008-5472.c.6496322.v1