Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Geneviève Thon"'
Autor:
Maria M. Jørgensen, Babatunde Ekundayo, Mikel Zaratiegui, Karen Skriver, Geneviève Thon, Thomas Schalch
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract The mechanism by which specific protein-DNA complexes induce programmed replication fork stalling in the eukaryotic genome remains poorly understood. In order to shed light on this process we carried out structural investigations on the esse
Externí odkaz:
https://doaj.org/article/928c8bb1f12547a5aec8f2641195749b
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Chromosomes contain large heterochromatin domains. Here, the authors measure the kinetics of heterochromatin formation in fission yeast and show both global and local feedbacks by nucleosome-bound enzymes are important for formation and stability of
Externí odkaz:
https://doaj.org/article/8880659a3dfa477c9b75c47c49059d14
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007424 (2018)
Mating-type switching in Schizosaccharomyces pombe entails programmed gene conversion events regulated by DNA replication, heterochromatin, and the HP1-like chromodomain protein Swi6. The whole mechanism remains to be fully understood. Using a gene d
Externí odkaz:
https://doaj.org/article/4ff933ff21ee44a7a5e2d2f41e590cb9
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003762 (2013)
Mating-type switching in fission yeast results from gene conversions of the active mat1 locus by heterochromatic donors. mat1 is preferentially converted by mat2-P in M cells and by mat3-M in P cells. Here, we report that donor choice is governed by
Externí odkaz:
https://doaj.org/article/e509af0c255044b09a44722e83531786
Autor:
Julie Bonne Køhler, Maria Louise Mønster Jørgensen, Gabriele Beinoraité, Michael Thorsen, Geneviève Thon
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80442 (2013)
In eukaryotes many players in the DNA-damage response (DDR) catalyze protein sumoylation or ubiquitylation. Emphasis has been placed on how these modifications orchestrate the sequential recruitment of repair factors to sites of DNA damage or stalled
Externí odkaz:
https://doaj.org/article/f1b99d1b565e4c3eacb8058916c593d1
H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
Autor:
Klavs R Hansen, Idit Hazan, Sreenath Shanker, Stephen Watt, Janne Verhein-Hansen, Jürg Bähler, Robert A Martienssen, Janet F Partridge, Amikam Cohen, Geneviève Thon
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001268 (2011)
Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both m
Externí odkaz:
https://doaj.org/article/a670cdb460fd4b668806fc392be4176a
Publikováno v:
Maki, T, Thon, G & Iwasaki, H 2023, ' Fission yeast Swi2 designates cell-type specific donor and stimulates Rad51-driven strand exchange for mating-type switching ', Nucleic acids symposium series, vol. 51, no. 8 . https://doi.org/10.1093/nar/gkad204
A haploid of the fission yeast Schizosaccharomyces pombe expresses either the P or M mating-type, determined by the active, euchromatic, mat1 cassette. Mating-type is switched by Rad51-driven gene conversion of mat1 using a heterochromatic donor cass
Autor:
Alfredo Esquivel-Chávez, Takahisa Maki, Hideo Tsubouchi, Testuya Handa, Hiroshi Kimura, James E. Haber, Geneviève Thon, Hiroshi Iwasaki
Publikováno v:
Genes & Genetic Systems. 97:123-138
A haploid of the fission yeastSchizosaccharomyces pombeexpresses either the P or M matingtype, determined by the active, euchromatic,mat1cassette. Mating-type is switched by Rad51-driven gene conversion ofmat1using a heterochromatic donor cassette,ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fb7f3deb428a847bdf08dffd06abbce
https://doi.org/10.1101/2022.11.22.517464
https://doi.org/10.1101/2022.11.22.517464
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Charlton, S J, Jørgensen, M M & Thon, G 2020, ' Integrity of a heterochromatic domain ensured by its boundary elements ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 35, pp. 21504-21511 . https://doi.org/10.1073/pnas.2010062117
Charlton, S J, Jørgensen, M M & Thon, G 2020, ' Integrity of a heterochromatic domain ensured by its boundary elements ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 35, pp. 21504-21511 . https://doi.org/10.1073/pnas.2010062117
Significance The fission yeast silent mating-type region provides an excellent system to ask how chromatic domains with opposite effects on gene expression coexist side by side along chromosomes and to investigate roles played by DNA elements and arc