Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch

Autor: Nicolas Pichaud, Roxanne Bérubé, Geneviève Côté, Claude Belzile, France Dufresne, Geneviève Morrow, Robert M. Tanguay, David M. Rand, Pierre U. Blier

Publikováno v: Frontiers in Genetics, Vol 10 (2019)

Mitochondrial and nuclear genomes have to coevolve to ensure the proper functioning of the different mitochondrial complexes that are assembled from peptides encoded by both genomes. Mismatch between these genomes is believed to be strongly selected

Externí odkaz: https://doaj.org/article/b5e819ae689342ff913d2f54f925cab4

Effect of N-terminal region of nuclear Drosophila melanogaster small heat shock protein DmHsp27 on function and quaternary structure.

Autor: Mohamed Taha Moutaoufik, Geneviève Morrow, Stéphanie Finet, Robert M Tanguay

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0177821 (2017)

The importance of the N-terminal region (NTR) in the oligomerization and chaperone-like activity of the Drosophila melanogaster small nuclear heat shock protein DmHsp27 was investigated by mutagenesis using size exclusion chromatography and native ge

Externí odkaz: https://doaj.org/article/6ce6f4397dd844039f08dd97e4d2f726

Presence of three mutations in the fumarylacetoacetate hydrolase gene in a patient with atypical symptoms of hereditary tyrosinemia type I

Autor: Vincent Roy, Robert M. Tanguay, Maxime Bourrelle-Langlois, Geneviève Morrow, Natacha Dreumont

Publikováno v: Molecular Genetics and Metabolism. 127:58-63

Hereditary tyrosinemia type 1 (HT1), the most severe disease of the tyrosine catabolic pathway, is caused by a deficiency of fumarylacetoacetate hydrolase (FAH). More than 90 disease-causing variants have been identified in the fah gene. We investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6a3d40eec74808c0f3d18899b09abc
https://doi.org/10.1016/j.ymgme.2019.01.019

Molecular Aspects of the FAH Mutations Involved in HT1 Disease

Autor: Geneviève, Morrow, Francesca, Angileri, Robert M, Tanguay

Publikováno v: Advances in experimental medicine and biology. 959

Hereditary tyrosinemia type 1 (HT1) is caused by the lack of fumarylacetoacetate hydrolase (FAH), the last enzyme of the tyrosine catabolic pathway. Up to now, around 100 mutations in the FAH gene have been associated with HT1, and despite many effor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7054b3bdbf5ad5dfc018bca5b482b190
https://pubmed.ncbi.nlm.nih.gov/28755182

Effect of N-terminal region of nuclear Drosophila melanogaster small heat shock protein DmHsp27 on function and quaternary structure

Autor: Robert M. Tanguay, Geneviève Morrow, Stéphanie Finet, Mohamed Taha Moutaoufik

Publikováno v: PLoS ONE
PLoS ONE, 2017, 12 (5), pp.e0177821. ⟨10.1371/journal.pone.0177821⟩
PLoS ONE, Public Library of Science, 2017, 12 (5), pp.e0177821. ⟨10.1371/journal.pone.0177821⟩
PLoS ONE, Vol 12, Iss 5, p e0177821 (2017)

International audience; The importance of the N-terminal region (NTR) in the oligomerization and chaperone-like activity of the Drosophila melanogaster small nuclear heat shock protein DmHsp27 was investigated by mutagenesis using size exclusion chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778d748eceddf5e487e5ce13803aebf6
https://hal.sorbonne-universite.fr/hal-01534524/file/journal.pone.0177821.pdf