Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Geneviève M.C. Gasmi-Seabrook"'
Autor:
Mitsuhiko Ikura, Teklab Gebregiworgis, Christopher B. Marshall, Ki-Young Lee, Geneviève M.C. Gasmi-Seabrook, Masahiro Enomoto
Publikováno v:
Chemical Science
KRAS forms transient dimers and higher-order multimers (nanoclusters) on the plasma membrane, which drive MAPK signaling and cell proliferation. KRAS is a frequently mutated oncogene, and while it is well known that the most prevalent mutation, G12D,
Autor:
Teklab Gebregiworgis, Christopher B. Marshall, Fenneke KleinJan, Geneviève M.C. Gasmi-Seabrook, Ben J Eves, Masahiro Enomoto, Ningdi F Liu, Ki-Young Lee, Mitsuhiko Ikura, Zhenhao Fang
Publikováno v:
Journal of Biomolecular NMR. 74:531-554
Mutations in RAS oncogenes occur in ~ 30% of human cancers, with KRAS being the most frequently altered isoform. RAS proteins comprise a conserved GTPase domain and a C-terminal lipid-modified tail that is unique to each isoform. The GTPase domain is
Autor:
Mitsuhiko Ikura, Zhenhao Fang, Shohei Koide, Geneviève M.C. Gasmi-Seabrook, Masahiro Enomoto, Christopher B. Marshall, Ki-Young Lee, Le Zheng
Publikováno v:
Angew Chem Int Ed Engl
KRAS homo-dimerization has been implicated in the activation of RAF kinases, however, the mechanism and structural basis remain elusive. We developed a system to study KRAS dimerization on nanodiscs using paramagnetic relaxation enhancement (PRE) NMR
Autor:
Pierre Maisonneuve, Nicolas Joly, O. Gavet, Y. Thomas, Thierry Lorca, Anna Castro, P. Mader, Nicolas Tavernier, Geneviève M.C. Gasmi-Seabrook, Stephen Orlicky, Mary Dasso, L. van Hove, Lionel Pintard, Saroj G. Regmi, Nicholas M. Levinson, Griselda Velez-Aguilera, M. Poteau, Suzanne Vigneron, Frank Sicheri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-21922-w⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-21922-w⟩
Polo-like kinase 1 (Plk1) is instrumental for mitotic entry and progression. Plk1 is activated by phosphorylation on a conserved residue Thr210 in its activation segment by the Aurora A kinase (AURKA), a reaction that critically requires the co-facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6acee8b9ada9c7f45d5760fd63a6a8
http://hdl.handle.net/20.500.12278/33998
http://hdl.handle.net/20.500.12278/33998
Autor:
Le Zheng, Geneviève M.C. Gasmi-Seabrook, Mitsuhiko Ikura, Zhenhao Fang, Ku-Geng Huo, Christopher B. Marshall, Ming-Sound Tsao, Ki-Young Lee, Nadeem Moghal
Publikováno v:
Proc Natl Acad Sci U S A
Membrane anchoring of farnesylated KRAS is critical for activation of RAF kinases, yet our understanding of how these proteins interact on the membrane is limited to isolated domains. The RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF
Autor:
Claus Meyer, Geneviève M.C. Gasmi-Seabrook, Serena Menezes, Anne-Claude Gingras, Matthew J. Smith, Mitsuhiko Ikura, Rolf Marschalek, Rob C. Laister, Marilyn Goudreault, Trang Hoang, Mark D. Minden, André Haman, Elizabeth Ottoni, Noboru Ishiyama, Monika Tucholska
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Elucidation of activation mechanisms governing protein fusions is essential for therapeutic development. MLL undergoes rearrangement with numerous partners, including a recurrent translocation fusing the epigenetic regulator to a cytoplasmic RAS effe
Autor:
Benjamin G. Neel, Geneviève M.C. Gasmi-Seabrook, Mohammad T. Mazhab-Jafari, Yang Xu, Tadateru Nishikawa, Mitsuhiko Ikura, Zhenhao Fang, Jiani C. Yin, Matthew J. Smith, Christopher B. Marshall
RAS-like protein expressed in many tissues 1 (RIT1) is a disease-associated RAS subfamily small guanosine triphosphatase (GTPase). Recent studies revealed that germ-line and somatic RIT1 mutations can cause Noonan syndrome (NS), and drive proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf61b5c095c89b086cc3f6ed026a67c
https://europepmc.org/articles/PMC4957048/
https://europepmc.org/articles/PMC4957048/
Autor:
Mitsuhiko Ikura, Matthew J. Smith, Christopher B. Marshall, Vuk Stambolic, Robert Rottapel, Geneviève M.C. Gasmi-Seabrook, Mohammad T. Mazhab-Jafari, David Meiri
Publikováno v:
Methods. 57:473-485
The Ras superfamily of small GTPases is a large family of switch-like proteins that control diverse cellular functions, and their deregulation is associated with multiple disease processes. When bound to GTP they adopt a conformation that interacts w
Autor:
Voula Kanelis, Geneviève M.C. Gasmi-Seabrook, P. Lynne Howell, Diane Bona, Philipp Neudecker, Logan W. Donaldson, Alan R. Davidson, Karen L. Maxwell, Aled M. Edwards, Lisa G. Pell, Marc C. Morais
Publikováno v:
Journal of Molecular Biology. 403:468-479
Immunoglobulin (Ig)-like domains are found frequently on the surface of tailed double-stranded DNA bacteriophages, yet their functional role remains obscure. Here, we have investigated the structure and function of the C-terminal Ig-like domain of gp
Autor:
Mitsuhiko Ikura, Peter B. Stathopulos, Mohammad T. Mazhab-Jafari, Geneviève M.C. Gasmi-Seabrook, Benjamin G. Neel, Lewis E. Kay, Fuyuhiko Inagaki, Matthew J. Smith, Christopher B. Marshall
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(21)
K-RAS4B (Kirsten rat sarcoma viral oncogene homolog 4B) is a prenylated, membrane-associated GTPase protein that is a critical switch for the propagation of growth factor signaling pathways to diverse effector proteins, including rapidly accelerated