Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Geneviève, Vandercruyssen"'
Autor:
Geneviève Vandercruyssen, Origène Nyanguile, Leen Vijgen, Frederik Pauwels, Pascale Dehertogh, Koen Dockx, Hendrik L. De Bondt, Wendy Mostmans, Benoit Devogelaere, Gregory Fanning, Vendeville Sandrine Marie Hele, Pierre Raboisson, Oliver Lenz, Frederic Delouvroy, Ann Vos, Koen Vandyck, Katrien Vermeiren, Erna Cleiren, Walter Van den Broeck, Jan Martin Berke, Kenneth Simmen, Maxwell D. Cummings
Publikováno v:
Journal of Virology. 84:2923-2934
The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to
Autor:
David McGowan, Origène Nyanguile, Maxwell D. Cummings, Sandrine Vendeville, Koen Vandyck, Walter Van den Broeck, Carlo W. Boutton, Hendrik De Bondt, Ludo Quirynen, Katie Amssoms, Jean-François Bonfanti, Stefaan Last, Klara Rombauts, Abdellah Tahri, Lili Hu, Frédéric Delouvroy, Katrien Vermeiren, Geneviève Vandercruyssen, Liesbet Van der Helm, Erna Cleiren, Wendy Mostmans, Pedro Lory, Geert Pille, Kristof Van Emelen, Gregory Fanning, Frederik Pauwels, Tse-I Lin, Kenneth Simmen, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2492-2496
Optimization through parallel synthesis of a novel series of hepatitis C virus (HCV) NS5B polymerase inhibitors led to the identification of ( R )-11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-10-(6-methylpyridine-2-carbonyl)-2,3,4,5,10,11-h
Autor:
Kenneth Simmen, Pierre Raboisson, Frederic Delouvroy, Maxwell D. Cummings, Wendy Mostmans, Tania Ivens, Pascale Dehertogh, Liesbet van der Helm, Geneviève Vandercruyssen, Origène Nyanguile, Walter Van den Broeck, Carlo Boutton, Jean Francois Bonfanti, Frederik Pauwels, Ludo Maria Marcel Quirynen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:4420-4431
The exogenous control of hepatitis C virus (HCV) replication can be mediated through the inhibition of the RNA-dependent RNA polymerase (RdRp) activity of NS5B. Small-molecule inhibitors of NS5B include nucleoside and nonnucleoside analogs. Here, we
Autor:
Charlotte Vandesteene, Inge Keuleers, Erwin Sablon, Natasja Elsen, Geneviève Vandercruyssen, Ina Vandenbroucke, Kenny Helsens, Martin Reijans, Natania Peelman, Geert Maertens
Publikováno v:
Journal of Clinical Oncology. 35:e20519-e20519
e20519 Background: Current molecular testing for mutations and indels in EGFRexons 18, 19, 20 and 21 is still laborious and often requires > 5 days in specialized labs. Multiple slices of FFPE tissue are often needed. Lack of experience, time or tiss
Autor:
Edwin Yunhao, Gong, Hannah, Kenens, Tania, Ivens, Koen, Dockx, Katrien, Vermeiren, Geneviève, Vandercruyssen, Benoit, Devogelaere, Pedro, Lory, Guenter, Kraus
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1030
The nonstructural protein 5 (NS5) of dengue virus (DENV) plays a central role in the virus replication. It functions as a methyltransferase and an RNA-dependent RNA polymerase. As such, it is a promising target for antiviral drug development. To deve
Autor:
Katrien Vermeiren, Koen Dockx, Hannah Kenens, Pedro Lory, Guenter Kraus, Tania Ivens, Edwin Yunhao Gong, Geneviève Vandercruyssen, Benoit Devogelaere
Publikováno v:
Antiviral Methods and Protocols ISBN: 9781627034838
The nonstructural protein 5 (NS5) of dengue virus (DENV) plays a central role in the virus replication. It functions as a methyltransferase and an RNA-dependent RNA polymerase. As such, it is a promising target for antiviral drug development. To deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98561143392e4f1d7b4dceeb16575c5c
https://doi.org/10.1007/978-1-62703-484-5_19
https://doi.org/10.1007/978-1-62703-484-5_19
Autor:
Katrien Vermeiren, Erwin Sablon, Bart Claes, Ina Vandenbroucke, Geert Maertens, Alison V. Todd, Samantha Walker, Nicole E. Lima, Geneviève Vandercruyssen, Elisa Mokany, Lit Yeen Tan, Pascale Holemans, Evelien Rondelez, Inky De Baere
Publikováno v:
Cancer Research. 74:1502-1502
Introduction The MAPK/ERK pathway is a complex signaling cascade involved in many cancer types. KRAS and BRAF gene mutations are present in a number of cancers, including colon, lung and pancreas, and identification of mutations in these genes is of
Autor:
Tania Ivens, Koen Van Acker, Mark M. Kockx, Inky De Baere, Isabelle Vanden Bempt, Erwin Sablon, Benoit Devogelaere, Pascale Holemans, Evelien Rondelez, Ina Vandenbroucke, Geneviève Vandercruyssen, Bart Claes, Marijke Van der Auwera, Geert Maertens
Publikováno v:
Cancer Research. 73:4213-4213
Introduction Activating mutations in the BRAF gene are common in skin and colorectal tumors. In more than 90% of the cases, these mutations are located in the BRAF V600 codon (V600E and V600K). Targeted therapies like vemurafenib and dabrafenib have