Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Genevera I Allen"'
Autor:
Meigen Yu, Hui Ye, Ruth B De-Paula, Carl Grant Mangleburg, Timothy Wu, Tom V Lee, Yarong Li, Duc Duong, Bridget Phillips, Carlos Cruchaga, Genevera I Allen, Nicholas T Seyfried, Ismael Al-Ramahi, Juan Botas, Joshua M Shulman
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010760 (2023)
Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson's disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human ge
Externí odkaz:
https://doaj.org/article/2fca0b159dad43719f3d2b2f9cfef08b
Autor:
Luqin Gan, Genevera I Allen
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010577 (2022)
Consensus clustering has been widely used in bioinformatics and other applications to improve the accuracy, stability and reliability of clustering results. This approach ensembles cluster co-occurrences from multiple clustering runs on subsampled ob
Externí odkaz:
https://doaj.org/article/175943d5bdb848a99b9bbf3f3a4e5e00
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241707 (2020)
Even though there is a clear link between Alzheimer's Disease (AD) related neuropathology and cognitive decline, numerous studies have observed that healthy cognition can exist in the presence of extensive AD pathology, a phenomenon sometimes called
Externí odkaz:
https://doaj.org/article/87e04051c3b04fd295bb342fd5bb716c
Autor:
John Nagorski, Genevera I Allen
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203007 (2018)
Several modern genomic technologies, such as DNA-Methylation arrays, measure spatially registered probes that number in the hundreds of thousands across multiple chromosomes. The measured probes are by themselves less interesting scientifically; inst
Externí odkaz:
https://doaj.org/article/518308f96fa84c7fba7b0377f400e5ed
Autor:
Manjari eNarayan, Genevera I Allen
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Many complex brain disorders such as Autism Spectrum Disorders exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek to understand individual differ
Externí odkaz:
https://doaj.org/article/42f7f645c0cd4a15ad016d478e408f38
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87782 (2014)
Dysregulated microRNA (miRNA) expression is a well-established feature of human cancer. However, the role of specific miRNAs in determining cancer outcomes remains unclear. Using Level 3 expression data from the Cancer Genome Atlas (TCGA), we identif
Externí odkaz:
https://doaj.org/article/e4f42d26f60b46e1b62c7d9d37cae51e
Publikováno v:
J Comput Biol
Recent advances in single-cell RNA sequencing (scRNA-seq) technologies have yielded a powerful tool to measure gene expression of individual cells. One major challenge of the scRNA-seq data is that it usually contains a large amount of zero expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734282a8d6aaa592648e37e62fb8d0ea
https://doi.org/10.1089/cmb.2021.0403
https://doi.org/10.1089/cmb.2021.0403
Autor:
Xu Han, Wanli Wang, Li-Hua Ma, Ismael Al-Ramahi, Juan Botas, Kevin MacKenzie, Genevera I. Allen, Damian W. Young, Zhandong Liu, Mirjana Maletic-Savatic
Publikováno v:
bioRxiv
Nuclear Magnetic Resonance (NMR) spectroscopy is widely used to analyze metabolites in biological samples, but the analysis can be cumbersome and inaccurate. Here, we present a powerful automated tool, SPA-STOCSY (Spatial Clustering Algorithm - Stati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc191170f2b6b851e50aa7f17dcd38d1
https://doi.org/10.1101/2023.02.22.529564
https://doi.org/10.1101/2023.02.22.529564
Autor:
Minjie Wang, Genevera I Allen
Publikováno v:
Biometrika.
Summary Structural learning of Gaussian graphical models in the presence of latent variables has long been a challenging problem. Chandrasekaran et al. (2012) proposed a convex program for estimating a sparse graph plus a low-rank term that adjusts f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c137b0875414e7284e9477c76172ab1
https://doi.org/10.1093/biomet/asac060
https://doi.org/10.1093/biomet/asac060
Autor:
Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg, Timothy Wu, Yarong Li, Duc Duong, Genevera I. Allen, Nicholas T. Seyfried, Ismael Al-Ramahi, Juan Botas, Joshua M. Shulman
Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson’s disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c313a3a947ad9f375e61ef419b8789
https://doi.org/10.1101/2022.07.23.501240
https://doi.org/10.1101/2022.07.23.501240