Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Geneva M, Cunningham"'
Autor:
Erica L. Cantor, Fei Shen, Guanglong Jiang, Zhiyong Tan, Geneva M. Cunningham, Xi Wu, Santosh Philips, Bryan P. Schneider
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Induced pluripotent stem cells (iPSCs) are a valuable resource for neurological disease-modeling and drug discovery due to their ability to differentiate into neurons reflecting the genetics of the patient from which they are derived. iPSC-d
Externí odkaz:
https://doaj.org/article/b6d5bbd295394a6eb0f8cd97742aac89
Autor:
Geneva M Cunningham, Fei Shen, Xi Wu, Erica L Cantor, Laura Gardner, Santosh Philips, Guanglong Jiang, Casey L Bales, Zhiyong Tan, Yunlong Liu, Jun Wan, Jill C Fehrenbacher, Bryan P Schneider
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1009968 (2022)
Taxane-induced peripheral neuropathy (TIPN) is a devastating survivorship issue for many cancer patients. In addition to its impact on quality of life, this toxicity may lead to dose reductions or treatment discontinuation, adversely impacting surviv
Externí odkaz:
https://doaj.org/article/26c22c4a3462467f86aed207b0ab7cc5
Autor:
Yuji Ikeno, Madeline G. Roman, Colton Allen, Gene B. Hubbard, Geneva M. Cunningham, Lisa C. Flores, Christie Cheng, Yidong Bai
Publikováno v:
Aging Pathobiology and Therapeutics. 2:203-209
Background: This study was conducted to test the effects of thioredoxin (Trx)1 down-regulation in Trx2 transgenic [Tg(TXN2) +/0] mice on lifespan and age-related diseases. Our previous study with Tg(TXN2) +/0 mice showed that mitochondrial Trx overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aba31b3c49d1ded4bc5b7a0842c89b65
https://doi.org/10.31491/apt.2020.12.041
https://doi.org/10.31491/apt.2020.12.041
Autor:
Madeline G, Roman, Lisa C, Flores, Geneva M, Cunningham, Christie, Cheng, Sara, Dube, Colton, Allen, Holly, Van Remmen, Yidong, Bai, Gene B, Hubbard, Thomas L, Saunders, Yuji, Ikeno
Publikováno v:
Aging Pathobiology and Therapeutics. 2:20-31
Objective: In this study, the effects of overexpression of thioredoxin 2 (Trx2) on aging and age-related diseases were examined using Trx2 transgenic mice [Tg(TXN2)+/0]. Because our previous studies demonstrated that thioredoxin (Trx) overexpression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4109c52afb3ea8e5e7a9f4fc3d9653
https://doi.org/10.31491/apt.2020.03.009
https://doi.org/10.31491/apt.2020.03.009
Autor:
Yidong Bai, Yuji Ikeno, Thomas L. Saunders, Colton Allen, Geneva M. Cunningham, Madeline G. Roman, Christie Cheng, Lisa C. Flores, Gene B. Hubbard
Publikováno v:
Aging Pathobiol Ther
Our laboratory has conducted the first systematic survival studies to examine the biological effects of the antioxidant protein thioredoxin (Trx) on aging and age-related pathology. Our studies with C57BL/6 mice overexpressing Trx1 [Tg(act-TRX1) +/0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669518c20ff07b1e2d4257f30daafa0a
https://europepmc.org/articles/PMC9049237/
https://europepmc.org/articles/PMC9049237/
Autor:
Christie Cheng, Thomas L. Saunders, Lisa C. Flores, Gene B. Hubbard, Yidong Bai, Geneva M. Cunningham, Sara Dube, Joseph M. Valentine, Colton Allen, Yuji Ikeno, Madeline G. Roman
To investigate the role of increased levels of thioredoxin (Trx) in both the cytosol (Trx1) and mitochondria (Trx2) on aging, we have conducted a study to examine survival and age-related diseases using male mice overexpressing Trx1 and Trx2 (TXNTg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9776848e5862508621728942c36e5f
https://europepmc.org/articles/PMC6294725/
https://europepmc.org/articles/PMC6294725/
Autor:
Holly Van Remmen, Sara Dube, Madeline G. Roman, Lisa C. Flores, Colton Allen, Gene B. Hubbard, Geneva M. Cunningham, Yuji Ikeno, Christie Cheng, Thomas L. Saunders
Publikováno v:
Pathobiology of Aging & Age-related Diseases, Vol 8, Iss 1 (2018)
Pathobiology of Aging & Age Related Diseases
Pathobiology of Aging & Age Related Diseases
We examined the effects of continuous overexpression of thioredoxin (Trx) 1 on aging in Trx1 transgenic mice [Tg(TXN)+/0]. This study was conducted to test whether increased thioredoxin expression over the lifespan in mice would alter aging and age-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1b37149ef07b3f2169982bec966d79
https://doi.org/10.1080/20010001.2018.1533754
https://doi.org/10.1080/20010001.2018.1533754
Autor:
Gene B. Hubbard, Lisa C. Flores, Jonathan Gelfond, Yuji Ikeno, Adam B. Salmon, Geneva M. Cunningham, Yiqiang Zhang, Madeline G. Roman
Publikováno v:
Archives of biochemistry and biophysics. 576
In spite of intensive study, there is still controversy about the free radical or oxidative stress theory of aging, particularly in mammals. Our laboratory has conducted the first detailed studies on the role of thioredoxin (Trx) in the cytosol (Trx1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbca4c06da2f5c38919ca0f400571f
https://pubmed.ncbi.nlm.nih.gov/25726727
https://pubmed.ncbi.nlm.nih.gov/25726727
Autor:
Gene B. Hubbard, Adam B. Salmon, Yiqiang Zhang, Yuhong Liu, Madeline G. Roman, Lisa C. Flores, Yuji Ikeno, Geneva M. Cunningham
Publikováno v:
Free Radical Biology and Medicine. 76:S33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17006f0e6604ca43377c7d1d885513b
https://doi.org/10.1016/j.freeradbiomed.2014.10.447
https://doi.org/10.1016/j.freeradbiomed.2014.10.447
Autor:
Yuji Ikeno, Gene B. Hubbard, Adam B. Salmon, Yuhong Liu, Geneva M. Cunningham, Yiqiang Zhang, Madeline G. Roman, Lisa C. Flores
Publikováno v:
Free Radical Biology and Medicine. 76:S111
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f15486c9ab06904381a5943c6b821e
https://doi.org/10.1016/j.freeradbiomed.2014.10.233
https://doi.org/10.1016/j.freeradbiomed.2014.10.233