Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Genetics and Genomics/Cancer Genetics"'
Autor:
Tom L. Blundell, Sungsam Gong
Publikováno v:
PLoS ONE; Vol 5
PLoS ONE
PLoS ONE, Vol 5, Iss 2, p e9186 (2010)
PLoS ONE
PLoS ONE, Vol 5, Iss 2, p e9186 (2010)
Human genetic variation is the incarnation of diverse evolutionary history, which reflects both selectively advantageous and selectively neutral change. In this study, we catalogue structural and functional features of proteins that restrain genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f1edadd0ac39045d217be78107d0a9
Autor:
Andrea Pession, Paola Bellosta, Marcello Ziosi, Annalisa Pession, Flavio Garoia, Daniela Grifoni, Luis Alberto Baena-Lopez, Francesca Froldi, Vincenzo Trotta, Sandro Cavicchi
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001140 (2010)
PLoS Genetics
PLoS Genetics
Genetic analyses in Drosophila epithelia have suggested that the phenomenon of “cell competition” could participate in organ homeostasis. It has been speculated that competition between different cell populations within a growing organ might play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b437feb7de32b8c78a4a741e19d25e02
https://doi.org/10.1371/journal.pgen.1001140
https://doi.org/10.1371/journal.pgen.1001140
Autor:
Zara Ghazoui, Sunil Pancholi, Anita K. Dunbier, Suzanne Drury, Lesley-Ann Martin, Kally Sidhu, Elena Lopez-Knowles, Ricardo Ribas, Helen Anderson, Mitch Dowsett, Alexandra Leary
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1001382 (2011)
PLoS Genetics
PLoS Genetics
Approximately 80% of human breast carcinomas present as oestrogen receptor α-positive (ER+ve) disease, and ER status is a critical factor in treatment decision-making. Recently, single nucleotide polymorphisms (SNPs) in the region immediately upstre
Autor:
Tongzhang Zheng, Lucia Conde, John J. Spinelli, Susan L. Slager, James R. Cerhan, Karin E. Smedby, Jianjun Liu, Thomas M. Habermann, Angela Brooks-Wilson, Mark P. Purdue, Lars Klareskog, Edison T. Liu, Leonid Padyukov, Jia Nee Foo, Henrik Hjalgrim, Bruce K. Armstrong, Emil Rehnberg, Martyn T. Smith, Nathaniel Rothman, Lars P. Ryder, Stephen J. Chanock, Bengt Glimelius, Scott Davis, Sam Milliken, Peter Boyle, Keith Humphreys, Ishak D. Irwan, Luz Agana, Lindsay M. Morton, Richard K. Severson, Shelia Hoar Zahm, Zachary S. Fredericksen, Stephen Leach, Qing Lan, Paige M. Bracci, Patricia Hartge, Yawei Zhang, Mads Melbye, Christine F. Skibola, Anne Kricker, Sophia S. Wang, Neil E. Kay, Jacques Riby, Ellen T. Chang, Hans-Olov Adami, Vikrant Kumar, Peter de Nully Brown, Wendy Cozen, Anne J. Novak, Hatef Darabi, Claire M. Vajdic, Lars Alfredsson
Publikováno v:
PLoS Genetics
PLoS genetics, vol 7, iss 4
PLoS Genetics, Vol 7, Iss 4, p e1001378 (2011)
PLoS Genetics, vol 7, iss 4
PLoS genetics, vol 7, iss 4
PLoS Genetics, Vol 7, Iss 4, p e1001378 (2011)
PLoS Genetics, vol 7, iss 4
Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antige
Autor:
Stavros Garantziotis, Michael A. Resnick, Kathleen M. Azzam, Daniel Menendez, Michael B. Fessler, Maria Shatz
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001360 (2011)
PLoS Genetics
PLoS Genetics
In recent years the functions that the p53 tumor suppressor plays in human biology have been greatly extended beyond “guardian of the genome.” Our studies of promoter response element sequences targeted by the p53 master regulatory transcription
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 3, p e14749 (2011)
PLoS ONE, Vol 6, Iss 3, p e14749 (2011)
BACKGROUND: EPHX1 is a key enzyme in metabolizing some exogenous carcinogens such as products of cigarette-smoking. Two functional polymorphisms in the EPHX1 gene, Tyr113His and His139Arg can alter the enzyme activity, suggesting their possible assoc
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001355 (2011)
PLoS Genetics
PLoS Genetics
SUMO conjugation is a key regulator of the cellular response to DNA replication stress, acting in part to control recombination at stalled DNA replication forks. Here we examine recombination-related phenotypes in yeast mutants defective for the SUMO
Autor:
Alan D. Hutson, Alphons P. M. Stassen, Neelima Kakarlapudi, Peter Demant, Claudia A. L. Ruivenkamp, Augustinus A. M. Hart, Remond J.A. Fijneman, Tom van Wezel, Lei Quan
Publikováno v:
PLoS ONE, 6(2):e14727. Public Library of Science
PLoS ONE, Vol 6, Iss 2, p e14727 (2011)
Quan, L, Stassen, A P, Ruivenkamp, C A, van Wezel, T, Fijneman, R J A, Hutson, A, Kakarlapudi, N, Hart, A A & Demant, P 2011, ' Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats. ', PLoS ONE, vol. 6, no. 2, e14727 . https://doi.org/10.1371/journal.pone.0014727
PLoS ONE, 6(2)
PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e14727 (2011)
Quan, L, Stassen, A P, Ruivenkamp, C A, van Wezel, T, Fijneman, R J A, Hutson, A, Kakarlapudi, N, Hart, A A & Demant, P 2011, ' Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats. ', PLoS ONE, vol. 6, no. 2, e14727 . https://doi.org/10.1371/journal.pone.0014727
PLoS ONE, 6(2)
PLoS ONE
Genetic predisposition controlled by susceptibility quantitative trait loci (QTLs) contributes to a large proportion of common cancers. Studies of genetics of cancer susceptibility, however, did not address systematically the relationship between sus
Autor:
Zhiying Ji, Martyn T. Smith, Xuefeng Ren, Jessica Yuh, Sophia Lim, Luoping Zhang, Vivian Peng
Publikováno v:
PLoS ONE
PloS one, vol 6, iss 1
PLoS ONE, Vol 6, Iss 1, p e14546 (2011)
PloS one, vol 6, iss 1
PLoS ONE, Vol 6, Iss 1, p e14546 (2011)
Background Werner syndrome (WS) results from defects in the RecQ helicase (WRN) and is characterized by premature aging and accelerated tumorigenesis. Contradictorily, WRN deficient human fibroblasts derived from WS patients show a characteristically
Autor:
Sol Efroni, Michael N. Edmonson, Carl F. Schaefer, Rotem Ben-Hamo, Kenneth H. Buetow, Sharon Greenblum
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14437 (2011)
PLoS ONE
PLoS ONE
High resolution, system-wide characterizations have demonstrated the capacity to identify genomic regions that undergo genomic aberrations. Such research efforts often aim at associating these regions with disease etiology and outcome. Identifying th