Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Genetically modified mammal"'
Publikováno v:
Protein Deimination in Human Health and Disease ISBN: 9783319582436
Peptidylarginine deiminases (PADs or PADIs) are a family of calcium-dependent enzymes that post-translationally convert positively charged arginine residues to neutrally charged citrulline in a process called citrullination or deimination. There are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b30adfaa1bbc2a34aa6fe8befdf00285
https://doi.org/10.1007/978-3-319-58244-3_4
https://doi.org/10.1007/978-3-319-58244-3_4
Genetically modified animals were first created in the 1970s–1980s, and are considered good models of human diseases. In this chapter, the types of genetically engineered mice, like transgenic, knockout, conditional knockout and knock-in animals, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930bcd8f87bc92c2f8c739cbcec10bd4
https://doi.org/10.1016/b978-0-12-809468-6.00027-9
https://doi.org/10.1016/b978-0-12-809468-6.00027-9
Autor:
Liangxue Lai, Nana Fan
Publikováno v:
Journal of Genetics and Genomics. 40:67-73
Genetically modified animal models are important for understanding the pathogenesis of human disease and developing therapeutic strategies. Although genetically modified mice have been widely used to model human diseases, some of these mouse models d
Publikováno v:
The Cancer Journal. 18:502-510
Pancreatic ductal adenocarcinoma is the 10th most common cancer and the 4th leading cause of cancer-related death in the United States. Despite great effort, the prognosis for patients with this disease remains dismal with, a 5-year survival rate of
Autor:
L. Rudenko
Publikováno v:
Biotechnology Law Report. 28:227-240
Autor:
Hitomi Matsunari, Hiroshi Nagashima
Publikováno v:
Journal of Reproduction and Development. 55:225-230
Pigs are increasingly being recognized as good large-animal models for translational research, linking basic science to clinical applications in order to establish novel therapeutics. This article reviews the current status and future prospects of ge
Autor:
Aaron Levin
Publikováno v:
Psychiatric News. 42:22-27
For most of the 20th century, increasing numbers of genetically defined laboratory mice have been described and incorporated into biological research; this trend has accelerated in the 21st century. Initially, research using inbred strains was limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d59c9999662ca2ed57ba0fb7ba74e8c
https://doi.org/10.1016/b978-0-12-409527-4.00032-8
https://doi.org/10.1016/b978-0-12-409527-4.00032-8
Autor:
Sethu Sankaranarayanan
Publikováno v:
Current Topics in Medicinal Chemistry. 6:609-627
Transgenic mice models for Alzheimer's disease (AD) are essential to the understanding of disease pathophysiology, develop robust behavioral models and predict outcomes from pharmacological interventions. In the last 10 years, numerous mice models ha
Publikováno v:
Russian Journal of Genetics. 40:235-238
Targeted genetic modification of embryonic stem cells (ESC) was used to obtain nondifferentiated cell clones containing the foreign genetic material in the genome. It was demonstrated that transgenic animals may be obtained by ESC injection in preimp