Zobrazeno 1 - 10
of 411
pro vyhledávání: '"Genetically engineered mouse model"'
Autor:
Marta Piqué-Gili, Carmen Andreu-Oller, Agavni Mesropian, Roger Esteban-Fabró, Marina Bárcena-Varela, Marina Ruiz de Galarreta, Carla Montironi, Iris Martinez-Quetglas, Sarah Cappuyns, Judit Peix, Ieva Keraite, Albert Gris-Oliver, Elisa Fernández-Martínez, Ezequiel Mauro, Miguel Torres-Martin, Jordi Abril-Fornaguera, Katherine E. Lindblad, Diether Lambrechts, Jeroen Dekervel, Swan N. Thung, Daniela Sia, Amaia Lujambio, Roser Pinyol, Josep M. Llovet
Publikováno v:
JHEP Reports, Vol 6, Iss 11, Pp 101212- (2024)
Background & Aims: Transforming growth factor β (TGF-β) plays an oncogenic role in advanced cancer by promoting cell proliferation, metastasis and immunosuppression. PMEPA1 (prostate transmembrane protein androgen induced 1) has been shown to promo
Externí odkaz:
https://doaj.org/article/93d51b39e7c4419c83008f56aa023b9c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
This review systematically describes the application of in vivo mouse models in studying cutaneous T-cell lymphoma (CTCL), a complex hematological neoplasm. It highlights the diverse research approaches essential for understanding CTCL’s intricate
Externí odkaz:
https://doaj.org/article/eea5fb9e54a5464b902ec87f18c9ab23
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 48, Iss , Pp 100956- (2024)
Introduction: Pleomorphic liposarcoma is a rare and aggressive subset of soft-tissue sarcomas with a high mortality burden. Local treatment largely consists of radiation therapy and wide surgical resection, but options for systemic therapy in the set
Externí odkaz:
https://doaj.org/article/1803ad9189514937a0f546329a12e63b
Publikováno v:
Antibodies, Vol 13, Iss 1, p 14 (2024)
Bispecific antibodies have gained increasing popularity as therapeutics as they enable novel activities that cannot be achieved with monospecific antibodies. Some of the most popular bispecific formats are molecules in which two Fab arms with differe
Externí odkaz:
https://doaj.org/article/c23df2f5d0214866b8a5840765d9f0ed
Akademický článek
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Akademický článek
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Publikováno v:
Zhongguo aizheng zazhi, Vol 32, Iss 9, Pp 779-785 (2022)
Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is a rare, heterogeneous tumor that can be divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) due to its degree of differentiation. With the gradual deepening of the exp
Externí odkaz:
https://doaj.org/article/060c8fb824fe4d79a25d09370e04ba35
Autor:
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y Chang
Publikováno v:
eLife, Vol 11 (2022)
HOTAIR is a 2.2-kb long noncoding RNA (lncRNA) whose dysregulation has been linked to oncogenesis, defects in pattern formation during early development, and irregularities during the process of epithelial-to-mesenchymal transition (EMT). However, th
Externí odkaz:
https://doaj.org/article/741109f2ea6440da9dc2a4c9fc75863e
Autor:
Kimberly Bettano, Mark Zielstorff, Raquel Sevilla, Ruojing Yang, Heather Zhou, Thomas Rosahl, Jie Zhang-Hoover, Lily Y. Moy, Weisheng Zhang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 27, Iss , Pp 100781- (2022)
Cytotoxic CD8+ T cells are the primary effector cells mediating anti-tumor responses. In vivo monitoring of CD8+ T cells has broad implications for the development of novel cancer therapies. Here we describe the development of a genetically engineere
Externí odkaz:
https://doaj.org/article/91f1d11ab935479a80247794f6c32d0b
Autor:
Yu-Lin Lin, Yan Li
Publikováno v:
Genes and Diseases, Vol 7, Iss 3, Pp 336-350 (2020)
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death around the world due to advanced clinical stage at diagnosis, high incidence of recurrence and metastasis after surgical treatment. It is in urgent need to create
Externí odkaz:
https://doaj.org/article/9fcd743d405b4eb581b771127e010ea7