Firewalls prevent systemic dissemination of vectors derived from human adenovirus type 5 and suppress production of transgene-encoded antigen in a murine model of oral vaccination

Autor: Julien Revaud, Yves Unterfinger, Nicolas Rol, Muhammad Suleman, Julia Shaw, Sandra Galea, Françoise Gavard, Sandrine A. Lacour, Muriel Coulpier, Nicolas Versillé, Menzo Havenga, Bernard Klonjkowski, Gina Zanella, Stéphane Biacchesi, Nathalie Cordonnier, Blaise Corthésy, Juliette Ben Arous, Jennifer P. Richardson

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Frontiers, 2018, 8, pp.1-15. ⟨10.3389/fcimb.2018.00006⟩
Frontiers in Cellular and Infection Microbiology (8), 1-15. (2018)
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in cellular and infection microbiology, vol. 8, pp. 6

International audience; To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue, and cellular scales throughout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f353300351326b915fbe3cd0e13a784
https://hal.inrae.fr/hal-02627246

A 10 Patient Case Report on the Impact of Plasmapheresis Upon Neutralizing Factors Against Adeno-associated Virus (AAV) Types 1, 2, 6, and 8

Autor: Carole Masurier, Olivier Benveniste, Marie-Françoise Montus, Philippe Veron, Virginie Monteilhet, Samir Saheb, Christian Leborgne, Philippe Moullier, Sylvie Boutin

Publikováno v: Molecular Therapy
Molecular Therapy, Cell Press, 2011, 19 (11), pp.2084-91. ⟨10.1038/mt.2011.108⟩
Molecular Therapy, 2011, 19 (11), pp.2084-91. ⟨10.1038/mt.2011.108⟩

International audience; Adeno-associated viruses (AAV) are small, nonenveloped single-stranded DNA viruses which require helper viruses to facilitate efficient replication. These recombinant viruses are some of the most promising candidates for thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde1d739bbf7d021d0593489255eca32
https://doi.org/10.1038/mt.2011.108

Humoral and cellular capsid-specific immune responses to adeno-associated virus type 1 in randomized healthy donors

Autor: Carole Masurier, Philippe Veron, Christian Leborgne, Samia Martin, Virginie Monteilhet, Philippe Moullier, Sylvie Boutin

Publikováno v: J Immunol
J Immunol, 2012, 188 (12), pp.6418-24. ⟨10.4049/jimmunol.1200620⟩

A major impediment to the use of adeno-associated virus (AAV)-mediated gene delivery to muscle in clinical applications is the pre-existing immune responses against the vector. Pre-existing humoral response to different AAV serotypes is now well docu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f00e0f03059b2e9414ab71eb47fa047
https://pubmed.ncbi.nlm.nih.gov/22593612

CAR chasing: canine adenovirus vectors-all bite and no bark?

Autor: Eric J. Kremer

Publikováno v: The Journal of Gene Medicine
The Journal of Gene Medicine, Wiley, 2004, 6 Suppl 1, pp.S139--51. ⟨10.1002/jgm.497⟩

This review deals primarily with canine adenovirus serotype 2 (CAV-2) vectors and gives a simplified overview of how the various domains of virology, cellular and molecular biology, as well as immunology, come into play when trying to understand and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50bc350a8a06e3b7758a3f9c1d79d3fb
https://hal.archives-ouvertes.fr/hal-02262382