Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Genetic Vectors/ genetics"'
Autor:
Alexia Boizot, Sylvain Moser, Virginie Zimmer, Nicole Déglon, Mélanie Sipion, Sara Regio, Maria Rey, Morgane Humbel, Ludiwine Aeby, Mergim Ramosaj
Publikováno v:
Gene Therapy
Gene therapy, vol. 28, no. 1-2, pp. 75-88
Gene therapy, vol. 28, no. 1-2, pp. 75-88
Gene transfer is a widely developed technique for studying and treating genetic diseases. However, the development of therapeutic strategies is challenging, due to the cellular and functional complexity of the central nervous system (CNS), its large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0caf98d1e7ad605f836975aa1ada83fb
https://doi.org/10.1038/s41434-020-0172-6
https://doi.org/10.1038/s41434-020-0172-6
Autor:
Marc M. Himmelberg, Bettina Laursen, Hartwig R. Siebner, Freja Gam Østergaard, Alex R. Wade, Kenneth Vielsted Christensen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Østergaard, F G, Himmelberg, M M, Laursen, B, Siebner, H R, Wade, A R & Christensen, K V 2020, ' Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing ', Scientific Reports, vol. 10, 11869 . https://doi.org/10.1038/s41598-020-68808-3
Scientific Reports
Scientific Reports, 10(1):11869. Nature Publishing Group
Østergaard, F G, Himmelberg, M M, Laursen, B, Siebner, H R, Wade, A R & Christensen, K V 2020, ' Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing ', Scientific Reports, vol. 10, 11869 . https://doi.org/10.1038/s41598-020-68808-3
Scientific Reports
Scientific Reports, 10(1):11869. Nature Publishing Group
Biomarkers suitable for early diagnosis and monitoring disease progression are the cornerstone of developing disease-modifying treatments for neurodegenerative diseases such as Parkinson’s disease (PD). Besides motor complications, PD is also chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea5b50bc121cd23b258454811ed201d
https://doaj.org/article/0d30f39be362461791363a38bd12b9f6
https://doaj.org/article/0d30f39be362461791363a38bd12b9f6
Autor:
Gougeon, Marie-Lise, Poirier-Beaudouin, Béatrice, Ausseil, Jérome, Zérah, Michel, Artaud, Cécile, Heard, Jean-Michel, Deiva, Kumaran, Tardieu, Marc
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2021, 12, pp.655478. ⟨10.3389/fimmu.2021.655478⟩
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, 2021, 12, pp.655478. ⟨10.3389/fimmu.2021.655478⟩
Frontiers in Immunology, Frontiers, 2021, 12, pp.655478. ⟨10.3389/fimmu.2021.655478⟩
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, 2021, 12, pp.655478. ⟨10.3389/fimmu.2021.655478⟩
International audience; Mucopolysaccharidosis type IIIB syndrome (Sanfilippo disease) is a rare autosomic recessif disorder caused by mutations in the α-N-acetylglucosaminidase (NAGLU) gene coding for a lysosomal enzyme, leading to neurodegeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::264181ddb1d95ef2cdef9ef8f1850cc3
https://hal.sorbonne-universite.fr/hal-03241952/file/fimmu-12-655478.pdf
https://hal.sorbonne-universite.fr/hal-03241952/file/fimmu-12-655478.pdf
Autor:
Deschamps, Marina, Decot, Véronique, Giverne, Camille, Pinturaud, Marine, Vaissié, Alix, Parquet, Nathalie, Olivero, Sylvain, Mamez, Anne-Claire, Bay, Jacques-Olivier, Yakoub-Agha, Ibrahim, Ferrand, Christophe
Publikováno v:
Bulletin du cancer, Vol. 107, No 1S (2020) pp. S85-S93
The extraordinary and unexpected success of cellular immunotherapy using genetically engineered T-cells to express a chimeric antigen receptor (CAR) targeting CD19, in the treatment of refractory or relapsing B-hematological malignancies, has provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1400::fc3930c51bdf3f23532771b56c7ef998
https://archive-ouverte.unige.ch/unige:154738
https://archive-ouverte.unige.ch/unige:154738
Autor:
Otto-Wilhelm Merten, Lucile Nauwynck, Yohann Dickx, Lionel Galibert, Adrien Savy, Delphine Bonnin
Publikováno v:
Human Gene Therapy Methods
Hum Gene Ther Methods
Hum Gene Ther Methods, 2017, 28 (5), pp.277-289. ⟨10.1089/hgtb.2016.133⟩
Hum Gene Ther Methods
Hum Gene Ther Methods, 2017, 28 (5), pp.277-289. ⟨10.1089/hgtb.2016.133⟩
International audience; Adeno-associated virus (AAV) inverted terminal repeats (ITRs) are key elements of AAV. These guanine-cytosine-rich structures are involved in the replication and encapsidation of the AAV genome, along with its integration in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401339db4aad7de78be755e1e33f8aa7
https://doi.org/10.1089/hgtb.2016.133
https://doi.org/10.1089/hgtb.2016.133
Autor:
Diogo Casal, Mário Ferraz-Oliveira, José S. Ramalho, Valentina Vassilenko, José Carlos Ferreira-Silva, Eduarda Mota-Silva, João Goyri-O'Neill, Carlos Pontinha, Luís Mascarenhas-Lemos, Paula A. Videira, Diogo Pais, Maria Guadalupe-Cabral, Inês Iria, Sara Alves
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
The main aim of this work was to study the usefulness of human β-defensins 2 (BD-2) and 3 (BD-3), which are part of the innate immune system, in the treatment of infected ischemic skin flaps. We investigated the effect of transducing rat ischemic sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad4a22c918eb1f84a2c03c7016637da
https://hdl.handle.net/10400.17/3265
https://hdl.handle.net/10400.17/3265
Autor:
William H. Peranteau, William J. Zacharias, Barbara E. Coons, Deepthi Alapati, Alexandra C. Chadwick, Kshitiz Singh, Edward E. Morrisey, Haiying Li, John D. Stratigis, Wenjian Lv, Rajan Jain, Li Li, Nicholas J. Ahn, Kiran Musunuru, Philip W. Zoltick, Avery C. Rossidis, Heather A. Hartman
Publikováno v:
Cardiovascular Research
Nature medicine
Nature medicine
In utero gene editing has the potential to prenatally treat genetic diseases that result in significant morbidity and mortality before or shortly after birth. We assessed the viral vector-mediated delivery of clustered regularly interspaced short pal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccaae8b897439ca1f66181cdf77c632
https://pubmed.ncbi.nlm.nih.gov/30824914
https://pubmed.ncbi.nlm.nih.gov/30824914
Autor:
Sergio González, Nicolas Tricaud, Claire Perrin-Tricaud, Ruani N Fernando, Gerben Van Hameren
Publikováno v:
Methods in Molecular Biology ISBN: 9781493978618
Myelinated fibers are essential for the rapid and efficient propagation of nerve information throughout the body. These fibers result from an intimate crosstalk between myelinating glia and the myelinated axons and, because it is difficult to fully r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123aee55db2a18dea40102e61d18e1ca
https://doi.org/10.1007/978-1-4939-7862-5_21
https://doi.org/10.1007/978-1-4939-7862-5_21
Publikováno v:
Methods in molecular biology, vol. 1850, pp. 259-274
Here we describe methods for the production of adeno-associated viral (AAV) vectors by transient transfection of HEK293 cells grown in serum-free medium in orbital shaken bioreactors and the subsequent purification of vector particles. The protocol f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::e6c434cd3cf31698d41b1a9ee78bb8bf
https://serval.unil.ch/resource/serval:BIB_B1349188A5CB.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_B1349188A5CB.P001/REF.pdf
Autor:
Julien Revaud, Yves Unterfinger, Nicolas Rol, Muhammad Suleman, Julia Shaw, Sandra Galea, Françoise Gavard, Sandrine A. Lacour, Muriel Coulpier, Nicolas Versillé, Menzo Havenga, Bernard Klonjkowski, Gina Zanella, Stéphane Biacchesi, Nathalie Cordonnier, Blaise Corthésy, Juliette Ben Arous, Jennifer P. Richardson
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Frontiers, 2018, 8, pp.1-15. ⟨10.3389/fcimb.2018.00006⟩
Frontiers in Cellular and Infection Microbiology (8), 1-15. (2018)
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in cellular and infection microbiology, vol. 8, pp. 6
Frontiers in Cellular and Infection Microbiology, Frontiers, 2018, 8, pp.1-15. ⟨10.3389/fcimb.2018.00006⟩
Frontiers in Cellular and Infection Microbiology (8), 1-15. (2018)
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in cellular and infection microbiology, vol. 8, pp. 6
International audience; To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue, and cellular scales throughout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f353300351326b915fbe3cd0e13a784
https://hal.inrae.fr/hal-02627246
https://hal.inrae.fr/hal-02627246