Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Autor: Rico Rueedi, Yuri Milaneschi, Brenda W.J.H. Penninx, Neil Poulter, Karen Schwander, Marco Brumat, Kenneth Rice, Yize Li, Veronique Vitart, Ioanna Ntalla, Michele K. Evans, Jeffrey R. O'Connell, Nilesh J. Samani, Colleen M. Sitlani, W. James Gauderman, Xuan Deng, Paul M. Ridker, Yun J. Sung, Yukihide Momozawa, Archie Campbell, Tin Louie, Nona Sotoodehnia, Yii-Der Ida Chen, Cornelia M. van Duijn, Tanika N. Kelly, Peter S. Sever, André G. Uitterlinden, Brigitte Kühnel, John M. Starr, Lawrence F. Bielak, Christopher P. Nelson, Wanqing Wen, Stephan B. Felix, Stefan Weiss, Daniel Levy, Nicholette D. Palmer, Alisa K. Manning, Salman M. Tajuddin, Jill M. Norris, Marie Loh, M. Abdullah Said, Alena Stančáková, Anuradhani Kasturiratne, John M. C. Connell, Jian'an Luan, Tuomas O. Kilpeläinen, Amy R. Bentley, Stephen Sidney, Alan B. Zonderman, Karin Leander, David J. Porteous, Jianjun Liu, Tin Aung, Charles B. Eaton, Sharon L.R. Kardia, Rajkumar Dorajoo, Stephen Turner, Michael Boehnke, Diane M. Becker, Cora E. Lewis, Ozren Polasek, Mickaël Canouil, Kurt Lohman, Georg Ehret, Sarah E. Harris, Robert A. Scott, Claude Bouchard, Lynne E. Wagenknecht, Mohsen Ghanbari, Stephen B. Kritchevsky, Jin-Fang Chai, Gregory L. Burke, Jiang He, Federica Laguzzi, Michael R. Brown, Walter Palmas, Lili Milani, Thomas T. Perls, Tibor V. Varga, José Eduardo Krieger, Erin B. Ware, Tamara B. Harris, Tomohiro Katsuya, Nicole Schupf, Mika Kähönen, Nana Matoba, Hugues Aschard, Ilaria Gandin, Jennifer A. Smith, Traci M. Bartz, James Scott, Tuomo Rankinen, Yuan Shi, Meian He, Timo A. Lakka, Helen R. Warren, Mike A. Nalls, Kent D. Taylor, Woon-Puay Koh, Ya Xing Wang, Muhammad Riaz, Sandosh Padmanabhan, Mary F. Feitosa, Jost B. Jonas, Paul Elliott, Christian Gieger, Terho Lehtimäki, Kaare Christensen, Maris Alver, Pirjo Komulainen, Pamela J. Schreiner, M. Arfan Ikram, David R. Weir, Charles Kooperberg, Oscar H. Franco, Yongmei Liu, Lisa de las Fuentes, Nancy L. Pedersen, Thomas W. Winkler, Bruna Gigante, Göran Hallmans, Ingrid B. Borecki, Shiow Lin, Ian J. Deary, Wei Zheng, Yajuan Wang, Bernardo L. Horta, Heather M. Stringham, Bruce M. Psaty, Paul W. Franks, Weihua Zhang, Nora Franceschini, Adolfo Correa, Nita G. Forouhi, Xiuqing Guo, Fumihiko Takeuchi, L. Adrienne Cupples, William R. Scott, Zoltán Kutalik, He Gao, Nicholas J. Wareham, E. Shyong Tai, Aravinda Chakravarti, C. Charles Gu, Paolo Gasparini, Albertine J. Oldehinkel, Xueling Sim, Norihiro Kato, Evangelos Evangelou, Philippe Froguel, Colin A. McKenzie, Qing Duan, Aldi T. Kraja, Carsten Oliver Schmidt, Bamidele O. Tayo, Xiaofeng Zhu, Thomas Meitinger, Mary K. Wojczynski, Markku Laakso, Mark J. Caulfield, Carl D. Langefeld, Jingzhong Ding, Yechiel Friedlander, Tien Yin Wong, Virginia Fisher, Raymond Noordam, Caizheng Yu, Pim van der Harst, Yik Ying Teo, Ervin R. Fox, Sabanayagam Charumathi, Jonathan Marten, Nicholas Y.Q. Tan, Jerome I. Rotter, Harold Snieder, Karen L. Mohlke, Christine Williams, Olli T. Raitakari, Renée de Mutsert, Lihua Wang, Kathryn Roll, Jingmin Liu, Dongfeng Gu, Wei Zhao, Lynda M. Rose, Michael A. Province, Fernando Pires Hartwig, Rob M. van Dam, Barry I. Freedman, Andres Metspalu, Donald W. Bowden, Andrea R. V. R. Horimoto, Martin Farrall, Frits R. Rosendaal, Rainer Rauramaa, Konstantin Strauch, Albert V. Smith, Yanick Hagemeijer, Michiaki Kubo, Ilja M. Nolte, Tõnu Esko, Yih Chung Tham, Cathy C. Laurie, Antonietta Robino, Anne U. Jackson, Chuan Gao, Dabeeru C. Rao, Xiao-Ou Shu, H. Janaka de Silva, Morris J. Brown, Alanna C. Morrison, Peter J. van der Most, Jian-Min Yuan, Melanie Waldenberger, Leslie J. Raffel, Ulrich John, Fang-Chi Hsu, Reedik Mägi, Solomon K. Musani, Chiea Chuen Khor, Mario Sims, Ruben N. Eppinga, Melissa A. Richard, Yoichiro Kamatani, Changwei Li, Qiuyin Cai, Daniel I. Chasman, Mathilde Boissel, Claudia Langenberg, Sami Heikkinen, Jasmin Divers, Saima Afaq, Wen Bin Wei, Jaspal S. Kooner, Terrence Forrester, Hua Tang, Charles N. Rotimi, Anuj Goel, Annette Peters, Tangchun Wu, Dennis O. Mook-Kanamori, Caroline Hayward, Ching-Yu Cheng, Lisa R. Yanek, Ananda R. Wickremasinghe, Chew-Kiat Heng, Myriam Fornage, Dina Vojinovic, Najaf Amin, Lenore J. Launer, Hugh Watkins, Johanna Kuusisto, Jing Hua Zhao, Barbara V. Howard, Vilmundur Gudnason, Ulrich Broeckel, Eric Boerwinkle, Saskia P. Hagenaars, Dan E. Arking, Peter Vollenweider, Alexandre C. Pereira, Jie Yao, Makoto Hirata, Patricia B. Munroe, Patricia A. Peyser, Jessica D. Faul, Xu Chen, Patrik K. E. Magnusson, John C. Chambers, Tamar Sofer, Marzyeh Amini, Benjamin Lehne

Publikováno v: Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C-Y, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F-C, Jackson, A U, Kähönen, M, Zhao, J H, Kilpeläinen, T O, Christensen, K & V Varga, T 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166, pp. 1-36 . https://doi.org/10.1371/journal.pone.0198166
Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C Y, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F C, Jackson, A U, Kähönen, M, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Luan, JA, Matoba, N, Nolte, I M, Padmanabhan, S, Riaz, M, Rueedi, R, Robino, A, Said, M A, Scott, R A, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, B O, Van Der Most, P J, Varga, T V, Vitart, V, Wang, Y, Ware, E B, Warren, H R, Weiss, S, Wen, W, Yanek, L R, Zhang, W, Zhao, J H, Afaq, S, Amin, N, Amini, M, Arking, D E, Aung, T, Boerwinkle, E, Borecki, I, Broeckel, U, Brown, M, Brumat, M, Burke, G L, Canouil, M, Chakravarti, A, Charumathi, S, Chen, Y D I, Connell, J M, Correa, A, De Las Fuentes, L, De Mutsert, R, De Silva, H J, Deng, X, Ding, J, Duan, Q, Eaton, C B, Ehret, G, Eppinga, R N, Evangelou, E, Faul, J D, Felix, S B, Forouhi, N G, Forrester, T, Franco, O H, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gigante, B, Gu, C C, Gu, D, Hagenaars, S P, Hallmans, G, Harris, T B, He, J, Heikkinen, S, Heng, C K, Hirata, M, Howard, B V, Ikram, M A, John, U, Katsuya, T, Khor, C C, Kilpeläinen, T O, Koh, W P, Krieger, J E, Kritchevsky, S B, Kubo, M, Kuusisto, J, Lakka, T A, Langefeld, C D, Langenberg, C, Launer, L J, Lehne, B, Lewis, C E, Li, Y, Lin, S, Liu, J, Liu, J, Loh, M, Louie, T, Mägi, R, McKenzie, C A, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, K L, Momozawa, Y, Nalls, M A, Nelson, C P, Sotoodehnia, N, Norris, J M, O'Connell, J R, Palmer, N D, Perls, T, Pedersen, N L, Peters, A, Peyser, P A, Poulter, N, Raffel, L J, Raitakari, O T, Roll, K, Rose, L M, Rosendaal, F R, Rotter, J I, Schmidt, C O, Schreiner, P J, Schupf, N, Scott, W R, Sever, P S, Shi, Y, Sidney, S, Sims, M, Sitlani, C M, Smith, J A, Snieder, H, Starr, J M, Strauch, K, Stringham, H M, Tan, N Y Q, Tang, H, Taylor, K D, Teo, Y Y, Tham, Y C, Turner, S T, Uitterlinden, A G, Vollenweider, P, Waldenberger, M, Wang, L, Wang, Y X, Wei, W B, Williams, C, Yao, J, Yu, C, Yuan, J M, Zhao, W, Zonderman, A B, Becker, D M, Boehnke, M, Bowden, D W, Chambers, J C, Deary, I J, Esko, T, Farrall, M, Franks, P W, Freedman, B I, Froguel, P, Gasparini, P, Gieger, C, Jonas, J B, Kamatani, Y, Kato, N, Kooner, J S, Kutalik, Z, Laakso, M, Laurie, C C, Leander, K, Lehtimäki, T, Magnusson, P K E, Oldehinkel, A J, Penninx, B W J H, Polasek, O, Porteous, D J, Rauramaa, R, Samani, N J, Scott, J, Shu, X O, Van Der Harst, P, Wagenknecht, L E, Wareham, N J, Watkins, H, Weir, D R, Wickremasinghe, A R, Wu, T, Zheng, W, Bouchard, C, Christensen, K, Evans, M K, Gudnason, V, Horta, B L, Kardia, S L R, Liu, Y, Pereira, A C, Psaty, B M, Ridker, P M, Van Dam, R M, Gauderman, W J, Zhu, X, Mook-Kanamori, D O, Fornage, M, Rotimi, C N, Cupples, L A, Kelly, T N, Fox, E R, Hayward, C, Van Duijn, C M, Tai, E S, Wong, T Y, Kooperberg, C, Palmas, W, Rice, K, Morrison, A C, Elliott, P, Caulfield, M J, Munroe, P B, Rao, D C, Province, M A & Levy, D 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F, Jackson, A U, Kähönen, M, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Luan, J, Matoba, N, Nolte, I M, Padmanabhan, S, Riaz, M, Rueedi, R, Robino, A, Said, M A, Scott, R A, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, B O, Van Der Most, P J, Varga, T V, Vitart, V, Wang, Y, Ware, E B, Warren, H R, Weiss, S, Wen, W, Yanek, L R, Zhang, W, Zhao, J H, Afaq, S, Amin, N, Amini, M, Arking, D E, Aung, T, Boerwinkle, E, Borecki, I, Broeckel, U, Brown, M, Brumat, M, Burke, G L, Canouil, M, Chakravarti, A, Charumathi, S, Ida Chen, Y, Connell, J M, Correa, A, De Las Fuentes, L, De Mutsert, R, De Silva, H J, Deng, X, Ding, J, Duan, Q, Eaton, C B, Ehret, G, Eppinga, R N, Evangelou, E, Faul, J D, Felix, S B, Forouhi, N G, Forrester, T, Franco, O H, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gigante, B, Gu, C C, Gu, D, Hagenaars, S P, Hallmans, G, Harris, T B, He, J, Heikkinen, S, Heng, C, Hirata, M, Howard, B V, Ikram, M A, John, U, Katsuya, T, Khor, C C, Kilpeläinen, T O, Koh, W, Krieger, J E, Kritchevsky, S B, Kubo, M, Kuusisto, J, Lakka, T A, Langefeld, C D, Langenberg, C, Launer, L J, Lehne, B, Lewis, C E, Li, Y, Lin, S, Liu, J, Liu, J, Loh, M, Louie, T, Mägi, R, Mckenzie, C A, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, K L, Momozawa, Y, Nalls, M A, Nelson, C P, Sotoodehnia, N, Norris, J M, O'connell, J R, Palmer, N D, Perls, T, Pedersen, N L, Peters, A, Peyser, P A, Poulter, N, Raffel, L J, Raitakari, O T, Roll, K, Rose, L M, Rosendaal, F R, Rotter, J I, Schmidt, C O, Schreiner, P J, Schupf, N, Scott, W R, Sever, P S, Shi, Y, Sidney, S, Sims, M, Sitlani, C M, Smith, J A, Snieder, H, Starr, J M, Strauch, K, Stringham, H M, Tan, N Y Q, Tang, H, Taylor, K D, Teo, Y Y, Tham, Y C, Turner, S T, Uitterlinden, A G, Vollenweider, P, Waldenberger, M, Wang, L, Wang, Y X, Wei, W B, Williams, C, Yao, J, Yu, C, Yuan, J, Zhao, W, Zonderman, A B, Becker, D M, Boehnke, M, Bowden, D W, Chambers, J C, Deary, I J, Esko, T, Farrall, M, Franks, P W, Freedman, B I, Froguel, P, Gasparini, P, Gieger, C, Jonas, J B, Kamatani, Y, Kato, N, Kooner, J S, Kutalik, Z, Laakso, M, Laurie, C C, Leander, K, Lehtimäki, T, Study, L C, Magnusson, P K E, Oldehinkel, A J, Penninx, B W J H, Polasek, O, Porteous, D J, Rauramaa, R, Samani, N J, Scott, J, Shu, X, Van Der Harst, P, Wagenknecht, L E, Wareham, N J, Watkins, H, Weir, D R, Wickremasinghe, A R, Wu, T, Zheng, W, Bouchard, C, Christensen, K, Evans, M K, Gudnason, V, Horta, B L, Kardia, S L R, Liu, Y, Pereira, A C, Psaty, B M, Ridker, P M, Van Dam, R M, Gauderman, W J, Zhu, X, Mook-kanamori, D O, Fornage, M, Rotimi, C N, Cupples, L A, Kelly, T N, Fox, E R, Hayward, C, Van Duijn, C M, Tai, E S, Wong, T Y, Kooperberg, C, Palmas, W, Rice, K, Morrison, A C, Elliott, P, Caulfield, M J, Munroe, P B, Rao, D C, Province, M A, Levy, D & Kuivaniemi, H 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, pp. e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLoS One (online), 13(6):e0198166. Public Library of Science
PLoS ONE, 13(6):0198166. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE, Public Library of Science, 2018, 13 (6), pp.e0198166. ⟨10.1371/journal.pone.0198166⟩
PloS one, vol. 13, no. 6, pp. e0198166
PLoS ONE, Vol 13, Iss 6, p e0198166 (2018)
InterAct Consortium 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLOS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLOS ONE
PLoS ONE 13:e0198166 (2018)
Feitosa, M F & Levy, D 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLoS ONE, 2018, 13 (6), pp.e0198166. ⟨10.1371/journal.pone.0198166⟩
PLoS ONE, 13(6)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, 13(6):e0198166. Public Library of Science
PLOS ONE, Vol. 13, No 6 (2018) P. e0198166

Publisher's version (útgefin grein).
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766b707c74cf4663079aeb5681d2aef7
https://curis.ku.dk/portal/da/publications/novel-genetic-associations-for-blood-pressure-identified-via-genealcohol-interaction-in-up-to-570k-individuals-across-multiple-ancestries(bab90887-86d2-4a0e-810d-0e7f854caeb2).html

Familial influence on Parkinsonism in a rural area of Turkey (Kizilcaboluk-Denizli). A community-based case-control study

Autor: Huseyin Bagci, G. Ozan Çetin, Fatma Özdemir, Türker Şahiner, Peter Heutink, Füsun Düzcan, Vincenzo Bonifati, Mehmet Zencir

Publikováno v: Movement Disorders, 18(7), 799-830. John Wiley & Sons Inc.

This population-based study on parkinsonism in a genetically isolated community from a rural area of Turkey aimed to provide a selective evaluation of environmental and heritable risk factors. An increased prevalence of parkinsonism (4.1%) was detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417b076f85453e6365abc19a67e41f60
https://doi.org/10.1002/mds.10440

Effect of formal statistical significance on the credibility of observational associations

Autor: Ioannidis, J. P.

The author evaluated the implications of nominal statistical significance for changing the credibility of null versus alternative hypotheses across a large number of observational associations for which formal statistical significance (p < 0.05) was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::3cc3413c6e93ab0103a37986ed3907a9
http://olympias.lib.uoi.gr/jspui/handle/123456789/22207

Inferring Epidemic Contact Structure from Phylogenetic Trees

Autor: Cristina Cellerai, Viktor von Wyl, Thomas Klimkait, Huldrych F. Günthard, Tanja Stadler, Roger D. Kouyos, Jürg Böni, Gabriel E. Leventhal, Sabine Yerly, Sebastian Bonhoeffer

Publikováno v: PLoS Computational Biology; Vol 8
PLoS Computational Biology, 8 (3)
PLoS computational biology
PLoS Computational Biology
Plos Computational Biology, vol. 8, no. 3, pp. e1002413
PLOS Computational Biology, Vol. 8, No 3 (2012) P. e1002413
PLoS Computational Biology, Vol 8, Iss 3, p e1002413 (2012)

Contact structure is believed to have a large impact on epidemic spreading and consequently using networks to model such contact structure continues to gain interest in epidemiology. However, detailed knowledge of the exact contact structure underlyi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b53d059103b8496d7338ef4679cd19c