Zobrazeno 1 - 10
of 1 801
pro vyhledávání: '"Genetic Association Study"'
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Background Statistical epistasis, or “gene–gene interaction” in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype. In the genetic association an
Externí odkaz:
https://doaj.org/article/0997d52df1904c5abce4a8fc29f1135b
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
The incidence and mortality of chronic kidney disease (CKD) are increasing globally. Studies have demonstrated the significance of genetic risk factors in the progression of CKD. Telomerase reverse transcriptase (TERT) may be implicated in the develo
Externí odkaz:
https://doaj.org/article/ed2431b67bba4819a371e0e91cde0fc8
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Migraine is a common neurological disorder that affects more than one billion people worldwide. Recent genome-wide association studies have identified 123 genetic loci associated with migraine risk. However, the biological mechanisms underlying migra
Externí odkaz:
https://doaj.org/article/f50416d995cd4e768a82b126c276f55e
Autor:
Joseph T. Glessner, Munir E. Khan, Xiao Chang, Yichuan Liu, F. George Otieno, Maria Lemma, Isabella Slaby, Heather Hain, Frank Mentch, Jin Li, Charlly Kao, Patrick M. A. Sleiman, Michael E. March, John Connolly, Hakon Hakonarson
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 15, Iss 1, Pp 1-11 (2023)
Abstract Background Neurodevelopmental disorders (NDDs), such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are examples of complex and partially overlapping phenotypes that often lack definitive corroborating
Externí odkaz:
https://doaj.org/article/b1950642f94a49809f8e4e46bdf5f5ad
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-9 (2023)
Abstract Background Diabetes mellitus (DM) is a well-established determinant of atherosclerosis and cardiovascular diseases (CVD). Recently, genome-wide association studies (GWAS) identified several single nucleotide polymorphism (SNP) significantly
Externí odkaz:
https://doaj.org/article/f65d1335e5514c2dbff1e463bde4a375
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 23, Iss 1, Pp 1-10 (2022)
Key points 1. MIR146A (C allele) had a protective role in rheumatoid arthritis association. MTMR3 was associated with rheumatoid arthritis using the dominant, Co-dominant heterozygote and recessive models. MIR499/MIR499A had no association with rheum
Externí odkaz:
https://doaj.org/article/6696fd5605c147f1989ce936a930b7bf
Akademický článek
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Autor:
Chris M. Pappas, Moussa A. Zouache, Stacie Matthews, Caitlin D. Faust, Jill L. Hageman, Brandi L. Williams, Burt T. Richards, Gregory S. Hageman
Publikováno v:
Human Genomics, Vol 15, Iss 1, Pp 1-15 (2021)
Abstract Background Single-variant associations with age-related macular degeneration (AMD), one of the most prevalent causes of irreversible vision loss worldwide, have been studied extensively. However, because of a lack of refinement of these asso
Externí odkaz:
https://doaj.org/article/b770e6f69a7d40b394cde71ed55256da
Akademický článek
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Autor:
Mohamed M. Emara, Maiada M. Mahmoud, Mohamed N. Saad, Mai S. Mabrouk, Mohamed Hamed, Olfat G. Shaker
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-7 (2021)
Abstract Background Behcet’s disease (BD) is a systemic inflammatory disease of the blood vessels and affects various body parts. This study aimed to determine the association of four single-nucleotide polymorphisms (SNPs) and BD in the Egyptian po
Externí odkaz:
https://doaj.org/article/bfd50e00978342fd9a1514a7c86845d6