Výsledky vyhledávání - "Genes and Health Research Team"

Akademický článek

Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom

Autor: Julia Zöllner, Sarah Finer, Kenneth J. Linton, Genes and Health Research Team, David A. van Heel, Catherine Williamson, Peter H. Dixon

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract This study assessed the contribution of five genes previously known to be involved in cholestatic liver disease in British Bangladeshi and Pakistani people. Five genes (ABCB4, ABCB11, ATP8B1, NR1H4, TJP2) were interrogated by exome sequencin

Externí odkaz: https://doaj.org/article/5f99e23ac98e467ea4d0f83ceaecfa77

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning.

Autor: Monti R; Hasso Plattner Institute, University of Potsdam, Digital Engineering Faculty, Potsdam, Germany; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin Institute for Medical Systems Biology, Berlin, Germany., Eick L; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Hudjashov G; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Läll K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Wolford BN; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health, Norwegian University of Science and Technology, Trondheim, Norway., Wingfield B; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Pain O; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience; Institute of Psychiatry, Psychology and Neuroscience; King's College London, London, UK., Wharrie S; Aalto University, Department of Computer Science, Espoo, Finland., Jermy B; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., McMahon A; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Hartonen T; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Heyne H; Hasso Plattner Institute, University of Potsdam, Digital Engineering Faculty, Potsdam, Germany., Mars N; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA; Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lambert S; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; British Heart Foundation Cambridge Centre of Research Excellence, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health, Norwegian University of Science and Technology, Trondheim, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Inouye M; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK; British Heart Foundation Cambridge Centre of Research Excellence, School of Clinical Medicine, University of Cambridge, Cambridge, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Marttinen P; Aalto University, Department of Computer Science, Espoo, Finland., Ripatti S; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland., Ganna A; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Massachusetts General Hospital and Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lippert C; Hasso Plattner Institute, University of Potsdam, Digital Engineering Faculty, Potsdam, Germany; Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: christoph.lippert@hpi.de.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2024 Jul 11; Vol. 111 (7), pp. 1431-1447. Date of Electronic Publication: 2024 Jun 21.

Zobrazit plný text záznamu

Akademický článek

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.

Autor: Meng X; Division of Psychiatry, UCL, London, UK., Navoly G; UCL Genetics Institute, UCL, London, UK., Giannakopoulou O; Division of Psychiatry, UCL, London, UK., Levey DF; Department of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Koller D; Department of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain., Pathak GA; Department of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Koen N; SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Adams MJ; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Rentería ME; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Feng Y; Division of Psychiatry, UCL, London, UK., Gaziano JM; Department of Medicine, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Stein DJ; SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Zar HJ; SAMRC Unit on Child and Adolescent Health, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa., Campbell ML; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Trivedi B; Blizard Institute, Queen Mary University of London, London, UK., Finer S; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., McQuillin A; Division of Psychiatry, UCL, London, UK., Bass N; Division of Psychiatry, UCL, London, UK., Chundru VK; Wellcome Sanger Institute, Saffron Walden, UK., Martin HC; Wellcome Sanger Institute, Saffron Walden, UK., Huang QQ; Wellcome Sanger Institute, Saffron Walden, UK., Valkovskaya M; Division of Psychiatry, UCL, London, UK., Chu CY; Division of Psychiatry, UCL, London, UK., Kanjira S; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Kuo PH; Department of Public Health and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.; Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan., Chen HC; Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.; Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan., Tsai SJ; Institute of Brain Science and Division of Psychiatry, National Yang-Ming Chiao Tung University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan., Liu YL; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan., Kendler KS; Department of Psychiatry, VCU, Richmond, VA, USA., Peterson RE; Department of Psychiatry, VCU, Richmond, VA, USA.; Department of Psychiatry, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Cai N; Helmholtz Pioneer Campus, Helmholtz Munich, Neuherberg, Germany.; Computational Health Centre, Helmholtz Munich, Neuherberg, Germany.; Department of Medicine, Technical University of Munich, Munich, Germany., Fang Y; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Sen S; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Scott LJ; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Burmeister M; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Preuss MH; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Actkins KV; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Davis LK; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Uddin M; College of Public Health, University of South Florida, Tampa, FL, USA., Wani AH; College of Public Health, University of South Florida, Tampa, FL, USA., Wildman DE; Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA., Aiello AE; Robert N. Butler Columbia Aging Center, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Ursano RJ; Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, MA, USA., Kanai M; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rabinowitz JA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Maher BS; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Uhl G; Neurology and Pharmacology, University of Maryland, Maryland VA Healthcare System, Baltimore, MD, USA., Eaton W; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Cruz-Fuentes CS; Departamento de Genética, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñíz', Mexico City, Mexico., Martinez-Levy GA; Departamento de Genética, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñíz', Mexico City, Mexico., Campos AI; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China.; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China., Wassertheil-Smoller S; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Jiang Y; Department of Biostatistics, Emory University, Atlanta, GA, USA.; 23andMe, Inc., Mountain View, CA, USA., Tian C; 23andMe, Inc., Mountain View, CA, USA., Martin NG; Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Mitchell BL; Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Byrne EM; Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia., Awasthi S; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany., Coleman JRI; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Ripke S; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Cambridge, MA, USA., Sofer T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Institute for Genomics and Cancer, University of Edinburgh, Edinburgh, UK., Polimanti R; Department of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare Center, West Haven, CT, USA., Dunn EC; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA., Stein MB; Department of Psychiatry, UC San Diego School of Medicine, La Jolla, CA, USA.; Herbert Wertheim School of Public Health and Human Longevity, University of California San Diego, La Jolla, CA, USA.; Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA., Gelernter J; Department of Psychiatry, VA CT Healthcare Center, West Haven, CT, USA.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Lewis CM; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Medical and Molecular Genetics, King's College London, London, UK., Kuchenbaecker K; Division of Psychiatry, UCL, London, UK. k.kuchenbaecker@ucl.ac.uk.; UCL Genetics Institute, UCL, London, UK. k.kuchenbaecker@ucl.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2024 Feb; Vol. 56 (2), pp. 222-233. Date of Electronic Publication: 2024 Jan 04.

Zobrazit plný text záznamu

Akademický článek

Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom.

Autor: Zöllner J; University College London, London, UK., Finer S; Institute for Population Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Linton KJ; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., van Heel DA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Williamson C; Department of Women and Children's Health, School of Life Course Sciences, FOLSM, King's College London, 2.30W Hodgkin Building, Guy's Campus, London, SE1 1UL, UK. catherine.williamson@kcl.ac.uk., Dixon PH; Department of Women and Children's Health, School of Life Course Sciences, FOLSM, King's College London, 2.30W Hodgkin Building, Guy's Campus, London, SE1 1UL, UK.

Publikováno v: Scientific reports [Sci Rep] 2023 May 19; Vol. 13 (1), pp. 8120. Date of Electronic Publication: 2023 May 19.

Zobrazit plný text záznamu