Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.

Autor: Castano A; Department of Pharmacology, University of Colorado School of Medicine, Aurora, United States., Silvestre M; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom., Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States., Sanderson JL; Department of Pharmacology, University of Colorado School of Medicine, Aurora, United States., Ferrer CA; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States., Ong HW; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States., Lang Y; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States., Richardson W; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Silvaroli JA; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, United States., Bashore FM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States., Smith JL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States., Genereux IM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States., Dempster K; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom., Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States., Pabla NS; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, United States., Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Benke TA; Departments of Pediatrics, Pharmacology, Neurology and Otolaryngology, University of Colorado School of Medicine, Aurora, United States., Ultanir SK; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, United Kingdom., Axtman AD; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Publikováno v: ELife [Elife] 2023 Jul 25; Vol. 12. Date of Electronic Publication: 2023 Jul 25.