Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Genelle F. Harrison"'
Autor:
Iain R. Konigsberg, Bret Barnes, Monica Campbell, Elizabeth Davidson, Yingfei Zhen, Olivia Pallisard, Meher Preethi Boorgula, Corey Cox, Debmalya Nandy, Souvik Seal, Kristy Crooks, Evan Sticca, Genelle F. Harrison, Andrew Hopkinson, Alexis Vest, Cosby G. Arnold, Michael G. Kahn, David P. Kao, Brett R. Peterson, Stephen J. Wicks, Debashis Ghosh, Steve Horvath, Wanding Zhou, Rasika A. Mathias, Paul J. Norman, Rishi Porecha, Ivana V. Yang, Christopher R. Gignoux, Andrew A. Monte, Alem Taye, Kathleen C. Barnes
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-10 (2021)
Konigsberg et al. profile DNA methylation in blood samples from SARS-CoV-2 cases and controls. The authors use machine learning to classify infected vs. non-infected individuals and predict clinical outcomes related to disease severity.
Externí odkaz:
https://doaj.org/article/4065c7ad16474661ad9788df11b18ed6
Autor:
Genelle F Harrison, Laura Ann Leaton, Erica A Harrison, Katherine M Kichula, Marte K Viken, Jonathan Shortt, Christopher R Gignoux, Benedicte A Lie, Damjan Vukcevic, Stephen Leslie, Paul J Norman
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009059 (2022)
Highly polymorphic interaction of KIR3DL1 and KIR3DS1 with HLA class I ligands modulates the effector functions of natural killer (NK) cells and some T cells. This genetically determined diversity affects severity of infections, immune-mediated disea
Externí odkaz:
https://doaj.org/article/a40864831cbd4d36b90418c41972b80d
Publikováno v:
J Allergy Clin Immunol Pract
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive immunity. The extreme diversity of this interaction is genetically det
Autor:
Jonathan A. Shortt, Guobin Zhang, Paul Norman, Lisbeth A. Guethlein, Hong-yan Zou, Mingzhong Tang, Genelle F. Harrison, Liumei He, Peter Parham, William H. Palmer, R. Chen, Zhihui Deng, Mary Carrington, Wenxu Hong, Ge Sun, Christopher R. Gignoux, Xiaojiang Gao, Siqi Cai, Jianxin Zhen, Qiong Yu, Neda Nemat-Gorgani
Publikováno v:
Molecular Biology and Evolution
Human natural killer (NK) cells are essential for controlling infection, cancer, and fetal development. NK cell functions are modulated by interactions between polymorphic inhibitory killer cell immunoglobulin-like receptors (KIR) and polymorphic HLA
Autor:
Zulkafli Zefarina, Laura Ann Leaton, William H. Palmer, Paul Norman, Genelle F. Harrison, Hisham Atan Edinur, Faming Zhu, Ticiana Della Justina Farias, Katherine M Kichula, Che Ghazali Norul Hajar, Sudan Tao
Publikováno v:
Immunology
Killer cell immunoglobulin‐like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune‐mediated disease
Autor:
Susanne Arnold, Verena J. Schuenemann, Felix M. Key, Alexander H. Schmidt, Alexander Herbig, Diana Iraíz Hernández-Zaragoza, Madita S. Kairies, William H. Palmer, Rodrigo Barquera, Julian Susat, Ute V. Solloch, Oliver Kohlbacher, Madeline K. Robinson, Kirsten I. Bos, Maria A. Spyrou, Paul Norman, Jill A. Hollenbach, Joachim Wahl, Jürgen Sauter, Alexander Immel, Genelle F. Harrison, Stephen Forrest, Ben Krause-Kyora, Johannes Krause, Ella Reiter, András Szolek, Rainer Weiß
Publikováno v:
Molecular Biology and Evolution
Pathogens and associated outbreaks of infectious disease exert selective pressure on human populations, and any changes in allele frequencies that result may be especially evident for genes involved in immunity. In this regard, the 1346-1353 Yersinia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d03f6998714aa31bd542316de676c06
https://hdl.handle.net/21.11116/0000-0008-A72B-C21.11116/0000-0009-9675-A21.11116/0000-0009-9676-9
https://hdl.handle.net/21.11116/0000-0008-A72B-C21.11116/0000-0009-9675-A21.11116/0000-0009-9676-9
Autor:
Jonathan A. Shortt, Viken Mk, Harrison Ea, Laura Ann Leaton, Christopher R. Gignoux, Benedicte A. Lie, Genelle F. Harrison, Stephen Leslie, Damjan Vukcevic, Paul Norman
Highly polymorphic interactions of KIR3DL1 and KIR3DS1 with HLA class I ligands modulates the effector functions of natural killer (NK) cells and some T cells. This genetically determined diversity affects severity of infections, immune-mediated dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d424ff24f2d891183586a2dbe431a052
https://doi.org/10.1101/2021.05.13.443975
https://doi.org/10.1101/2021.05.13.443975
Autor:
Bret Barnes, David P. Kao, Alem Taye, Andrew Hopkinson, Evan Sticca, Brett R. Peterson, Wanding Zhou, Elizabeth J. Davidson, Genelle F. Harrison, Rishi Porecha, Michael G. Kahn, Debmalya Nandy, Corey Cox, Kristy Crooks, Alexis Vest, Cosby G. Arnold, Steve Horvath, Ivana V. Yang, Andrew A. Monte, Yingfei Zhen, Kathleen C. Barnes, Paul Norman, Debashis Ghosh, Rasika A. Mathias, Monica Campbell, Christopher R. Gignoux, Souvik Seal, Iain R. Konigsberg, Olivia Pallisard, Stephen J. Wicks, Meher Preethi Boorgula
Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused on RT-PCR1. Host epigenome manipulation post coronavirus infection2–4 suggests that DNA methylation signatures may differentiate patients with SARS-CoV-2 infection from u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17e12fe5f3f6e7102b0873edb8c1d695
https://doi.org/10.21203/rs.3.rs-334297/v1
https://doi.org/10.21203/rs.3.rs-334297/v1
Autor:
Peter Parham, Paul Norman, Siqi Cai, Xiaojiang Gao, Jonathan A. Shortt, Christopher R. Gignoux, Jianxin Zhen, Mary Carrington, Wenxu Hong, Mingzhong Tang, Guobin Zhang, Genelle F. Harrison, R. Chen, Zhihui Deng, Ge Sun, Qiong Yu, Neda Nemat-Gorgani, Hong-yan Zou, Liumei He, Lisbeth A. Guethlein
Human natural killer (NK) cells are essential for controlling infection, cancer and fetal development. NK cell functions are modulated by interactions between polymorphic inhibitory killer cell immunoglobulin-like receptors (KIR) and polymorphic HLA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc58795fdba371580c59e46896ae1acc
https://doi.org/10.1101/2020.07.29.227579
https://doi.org/10.1101/2020.07.29.227579
Autor:
Katherine M Kichula, Genelle F Harrison, Cassie Nelson, Allison Piluso, Brian M Freed, Michael Aubrey, K M Hameed, Paul J Norman
Publikováno v:
The Journal of Immunology. 206:26.15-26.15
Killer cell immunoglobulin-like receptors (KIR) modulate the activity of human NK cells by interacting with HLA class I ligands, influencing their response to pathogens, cancer and during pregnancy. Combinatorial diversity of HLA and KIR allotypes im