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Akademický článek

Exploring the mechanism of Gentiana rigescens Franch. in the treatment of pulmonary fibrosis based on network pharmacology

Autor: Hu Ming-xing, Song Yan-Qiu, Gao Peng-Fei, Li Hai-feng, Liu Wei-Hong

Publikováno v: SN Applied Sciences, Vol 5, Iss 12, Pp 1-9 (2023)

Abstract Pulmonary fibrosis (PF) is a severe chronic interstitial lung disease with high mortality, and there is currently a lack of definite and effective treatment methods. Studies have found that gentiopicroside, a secoiridoid glycoside compound d

Externí odkaz: https://doaj.org/article/6f9a13366e684a57838f8c1fd69a1be9

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Akademický článek

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Akademický článek

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Identification of the anti-COVID-19 mechanism of action of Han-Shi Blocking Lung using network pharmacology-integrated molecular docking

Autor: C. Yuan, P. Y. Chen, Z. C. Hong, H. Z. Wu, F. Wang, Y. F. Yang

Publikováno v: Tropical Journal of Pharmaceutical Research. 20:1241-1249

Purpose: To investigate the bio-active components and the potential mechanism of the prescription remedy, Han-Shi blocking lung, with network pharmacology with a view to expanding its application. Methods: Chemical components were first collected fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4075416360deb13fb6e3720f3bf9bc4a
https://doi.org/10.4314/tjpr.v20i6.21

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Network pharmacology and experimental validation to explore the molecular mechanisms of Bushen Huoxue for the treatment of premature ovarian insufficiency

Autor: Ying Cao, Jialin Lu, Yue Chen, Peijuan Wang, Jingyao She, Xuan Han

Publikováno v: Bioengineered, Vol 12, Iss 2, Pp 10345-10362 (2021)
Bioengineered
article-version (VoR) Version of Record

Bushen Huoxue (BSHX) has been applied in clinical traditional Chinese medicine treatment, and has definitive clinical efficacy in the treatment of Premature Ovarian Insufficiency (POI) in China. However, little is known of the underlying mechanism of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89780abc21d0ac7936345e234dd861e7
https://doaj.org/article/72961efa2e264f698608279df808953b

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Research on the Mechanism of Guizhi to Treat Nephrotic Syndrome Based on Network Pharmacology and Molecular Docking Technology

Autor: Guangli Du, Guofeng Meng, Jijia Sun, Qiang Li, Dan He, Shaoli Chen

Publikováno v: BioMed Research International, Vol 2021 (2021)
BioMed Research International

Objective. Nephrotic syndrome (NS) is a common glomerular disease caused by a variety of causes and is the second most common kidney disease. Guizhi is the key drug of Wulingsan in the treatment of NS. However, the action mechanism remains unclear. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c8f0fbb059d07b169764cd3d22ae8a
https://doi.org/10.1155/2021/8141075

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A Novel Ferroptosis-Related Gene Signature to Predict Prognosis in Patients with Head and Neck Squamous Cell Carcinoma

Autor: Dan-dan Guo, Yong-xu Wu, Li Xu, Zhao-Hui Liu, Ying-ying Li, Dan Long, Yang-chun Zhang

Publikováno v: Disease Markers
Disease Markers, Vol 2021 (2021)

The clinical TNM staging system is currently used to evaluate the prognosis of head and neck squamous cell carcinoma (HNSCC). The 5-year survival rate for patients with HNSCC is less than 50%, which is attributed to the lack of reliable prognostic bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953d12c85fa2b6d9781c8233371d7885
https://doi.org/10.1155/2021/5759927

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Integrated Strategy of UHPLC-Q-TOF-MS and Molecular Networking for Identification of Diterpenoids from Euphorbia fischeriana Steud. and Prediction of the Anti-Breast-Cancer Mechanism by the Network Pharmacological Method

Autor: Yu Sun, Li-Na Guo, Yukun Ma, Qi Liu, Jin-Ling Zhang, Tiancheng Ma, Jia Sun, Lei Liu

Publikováno v: Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)

Breast cancer is one of the most common malignancies in women worldwide. Traditional Chinese medicine has been used as adjunctive or complementary therapy for breast cancer. Diterpenoids from Euphorbia fischeriana Steud. have been demonstrated to pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aadf736637ebc180148bbd9a017a0e2
https://doi.org/10.1155/2021/3829434

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Comparative Host–Pathogen Interaction Analyses of SARS-CoV2 and Aspergillus fumigatus, and Pathogenesis of COVID-19-Associated Aspergillosis

Autor: Patrycja Golińska, Mahendra Rai, Fozia Farooq, Abdul Arif Khan, Sudhir K. Jain

Publikováno v: Microbial Ecology

COVID-19 caused a global catastrophe with a large number of cases making it one of the major pandemics of the human history. The clinical presentations of the disease are continuously challenging healthcare workers with the variation of pandemic wave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4959262bb9b98e0838cf5a8d0fe0fa9d
https://doi.org/10.1007/s00248-021-01913-6

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Study on the molecular mechanism of Guizhi Jia Shaoyao decoction for the treatment of knee osteoarthritis by utilizing network pharmacology and molecular docking technology

Autor: Huanyu Liu, Kunming Xie, Fasen Huang, Huan Liang, Lan Li, Jing-Lu Han, Hanjie Zhu, Qiong Wu, Pin Deng, Zhaojun Chen, Jingwei Tao, Zhichao Huang

Publikováno v: Allergologia et Immunopathologia. 49:16-30

Background and objective: Guizhi Jia Shaoyao decoction (GSD) is widely used in the clinical treatment of knee osteoarthritis (KOA). However, the underlying molecular mechanisms remain unclear. The aim of this study was to explore functional mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f83cb6135499b940689aa24fe46925
https://doi.org/10.15586/aei.v49i6.484

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