Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Gene regulation in immune cells"'
Autor:
Zheng Wang, Dorina Avram, Xin Zhang, Ryan Kolb, Ajaykumar Vishwakarma, Hongrui Xiang, Xuefeng Wu, Xian Huang, Katherine N. Gibson-Corley, Umasankar De, Andrew P. Voigt, Julia Klesney-Tait, Myung-Chul Kim, Dongyang Wang, Song Guo Zheng, Mingjia Li, Rhonda Bacher, Weizhou Zhang, Gaurav Pandey, Nicholas Borcherding, Jiajia Hu, Jian Tang, Haoyang Zhuang, Jinke Cheng, Yuwen Zhu, Daohong Zhou, Jinglu Lu, Theodore T. Drashansky, Paige Kluz, Kawther K. Ahmed, Yousef Zakharia, Zhengting Wang, Hua Liu, Eric Y. Helm, Jinsong Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, using single-cell RNA sequencing of immune ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926e3a2cc612c6ab949c8e15fe695d1c
https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81
https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81
Autor:
Charles C. Caldwell, Christian B. Bergmann, Holly S. Goetzman, Bruce D. Hammock, Dorothy M. Supp, Falk Gogolla, Debin Wan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific reports, vol 11, iss 1
Oxylipins modulate the behavior of immune cells in inflammation. Soluble epoxide hydrolase (sEH) converts anti-inflammatory epoxyeicosatrienoic acid (EET) to dihydroxyeicosatrienoic acid (DHET). An sEH-inhibitor, TPPU, has been demonstrated to amelio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f998fded3f9997fa71344ea4947fae
https://doaj.org/article/6300e06abb654c439c3679971309bcfc
https://doaj.org/article/6300e06abb654c439c3679971309bcfc
Autor:
Peng Wu, Dongsheng Chen, Wencheng Ding, Ping Wu, Hongyan Hou, Yong Bai, Yuwen Zhou, Kezhen Li, Shunian Xiang, Panhong Liu, Jia Ju, Ensong Guo, Jia Liu, Bin Yang, Junpeng Fan, Liang He, Ziyong Sun, Ling Feng, Jian Wang, Tangchun Wu, Hao Wang, Jin Cheng, Hui Xing, Yifan Meng, Yongsheng Li, Yuanliang Zhang, Hongbo Luo, Gang Xie, Xianmei Lan, Ye Tao, Jiafeng Li, Hao Yuan, Kang Huang, Wan Sun, Xiaobo Qian, Zhichao Li, Mingxi Huang, Peiwen Ding, Haoyu Wang, Jiaying Qiu, Feiyue Wang, Shiyou Wang, Jiacheng Zhu, Xiangning Ding, Chaochao Chai, Langchao Liang, Xiaoling Wang, Lihua Luo, Yuzhe Sun, Ying Yang, Zhenkun Zhuang, Tao Li, Lei Tian, Shaoqiao Zhang, Linnan Zhu, Ashley Chang, Lei Chen, Yiquan Wu, Xiaoyan Ma, Fang Chen, Yan Ren, Xun Xu, Siqi Liu, Huanming Yang, Lin Wang, Chaoyang Sun, Ding Ma, Xin Jin, Gang Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334bcce4fa5cdd867d06bf6c2c086e72
https://doaj.org/article/0ef75d87cd98488c9fc022958232ccad
https://doaj.org/article/0ef75d87cd98488c9fc022958232ccad
Autor:
David Brown, Prudence N. Gatt, Graeme J. Stewart, Steve Vucic, Fiona C. McKay, Christopher Liddle, Samantha P L Law, Scott N. Byrne, Prue H. Hart, David R. Booth, Stephen D. Schibeci, Grant P Parnell
Publikováno v:
Genes and Immunity
Although genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dcd9079bcb06a7e191eb8c74f83cde
http://europepmc.org/articles/PMC8387232
http://europepmc.org/articles/PMC8387232
Autor:
Daryl Shern Lim, Rhea Nadkarni, Sebastian Schafer, Shan Zhang, Owen J. L. Rackham, Ashley L. St. John, Radiance Lim, Vinh Thang Huynh, Vinay Tergaonkar, Sonia Chothani, David A. Stroud, Daniella H Hock, Baptiste Kerouanton, Lena Ho, Ying Chen, Chinmay K. Mantri, Wei Leong Chew, Franklin L. Zhong, Cheryl Q E Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications
Mito-SEPs are small open reading frame-encoded peptides that localize to the mitochondria to regulate metabolism. Motivated by an intriguing negative association between mito-SEPs and inflammation, here we screen for mito-SEPs that modify inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19beaec0d5ec40aa7133bf88b9e4cbd
https://doaj.org/article/c10b340027cd468680f3b74537ae38a8
https://doaj.org/article/c10b340027cd468680f3b74537ae38a8
Autor:
Shiv Pillai, Samuel J.H. Murphy, Vinay Mahajan, Hugues Allard-Chamard, Na Sun, Grace J. Yuen, Hamid Mattoo, Annaiah Cariappa, Vinayak Viswanadham, Maimuna Ahmad, Yesim Tuncay
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
The B1 and B2 lineages of B cells contribute to protection from pathogens in distinct ways. The role of the DNA CpG methylome in specifying these two B-cell fates is still unclear. Here we profile the CpG modifications and transcriptomes of peritonea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eee239ff6bbfae29faa7deb0e91b9c
https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c49
https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c49
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of malignancy in the world. DNA cytosine-5-methyltransferase 1 (DNMT1) play key roles in carcinogenesis and regulation of the immune micro-environment, but the gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33b52c4b9b3cd1fe60ec59ae7f11396
https://doaj.org/article/a1a1e6b334eb4ce5ac3981d84259539b
https://doaj.org/article/a1a1e6b334eb4ce5ac3981d84259539b
Autor:
Papaioannou, N.E., Salei, N., Rambichler, S., Ravi, K., Popovic, J., Küntzel, V., Lehmann, C.H.K., Fiancette, R., Salvermoser, J., Gajdasik, D.W., Mettler, R., Messerer, D., Carrelha, J., Ohnmacht, C., Haller, D., Stumm, R., Straub, T., Jacobsen, S.E.W., Schulz, C., Withers, D.R., Schotta, G., Dudziak, D., Schraml, B.U.
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nat. Commun. 12:464 (2021)
Nature Communications
Nat. Commun. 12:464 (2021)
Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2d14918140afd27c63ab1a3013382bcf
https://doaj.org/article/41e3849697dd487fb5c3e7640b8e444b
https://doaj.org/article/41e3849697dd487fb5c3e7640b8e444b
Autor:
Yukihiko Sugimoto, Eri Nakamura, Yoshinori Fukui, Mitsuyoshi Nakao, Soken Tsuchiya, Norihiro Tada, Fumiyuki Sasaki, Masaru Ishii, Keiko Kitajima, Satoshi Iwamoto, Kazuko Saeki, Chikara Meno, Toshiaki Okuno, Hirotsugu Uzawa, Tomoaki Koga, Takako Ichiki, Mai Ohba, Junichi Kikuta, Takehiko Yokomizo
Publikováno v:
Cellular and Molecular Immunology
Leukotriene B4 (LTB4) receptor 1 (BLT1) is a chemotactic G protein-coupled receptor expressed by leukocytes, such as granulocytes, macrophages, and activated T cells. Although there is growing evidence that BLT1 plays crucial roles in immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0927b199b8c5115f292bf679c3af067c
https://doi.org/10.1038/s41423-020-00559-7
https://doi.org/10.1038/s41423-020-00559-7
Autor:
Nian Liu, Pingping Zhu, Yong Tian, Liuliu Yang, Zusen Fan, Buqing Ye, L.L. He, H.B. Li, Benyu Liu, Tiankun Lu, Xiaoxiao Zhu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Group 3 innate lymphoid cells (ILC3) are an important regulator for immunity, inflammation and tissue homeostasis in the intestine, but how ILC3 activation is regulated remains elusive. Here we identify a new circular RNA (circRNA) circKcnt2 that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c0cacd82335630b2325d2866e0e057
http://link.springer.com/article/10.1038/s41467-020-17944-5
http://link.springer.com/article/10.1038/s41467-020-17944-5