Zobrazeno 1 - 10
of 330
pro vyhledávání: '"Gene module"'
Publikováno v:
Journal of Big Data, Vol 10, Iss 1, Pp 1-21 (2023)
Abstract Purposes Cancer mRNA vaccines are a promising strategy and a hot topic in cancer immunotherapy. However, mRNA vaccines for breast cancer (BRCA) remain undeveloped. This study aimed to identify potential tumor antigens for mRNA vaccine develo
Externí odkaz:
https://doaj.org/article/4dfc02ac90af4a2da97d7cbf8de520f5
Autor:
Xiaojun Liu, Chengying Hong, Yichun Jiang, Wei Li, Youlian Chen, Yonghui Ma, Pengfei Zhao, Tiyuan Li, Huaisheng Chen, Xueyan Liu, Lixin Cheng
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Sepsis is a life-threatening condition characterized by a harmful host response to infection with organ dysfunction. Annually about 20 million people are dead owing to sepsis and its mortality rates is as high as 20%. However, no studies hav
Externí odkaz:
https://doaj.org/article/73c695dfa2b04fc2b4e6cfb180bd3bf2
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Since genes do not function individually, the gene module is considered an important tool for interpreting gene expression profiles. In order to consider both functional similarity and expression similarity in module identification, GMIGAGO,
Externí odkaz:
https://doaj.org/article/3115a1648e2348c880f6b79d0042f10b
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Multi-omics data integration has emerged as a promising approach to identify patient subgroups. However, in terms of grouping genes (or gene products) into co-expression modules, data integration methods suffer from two main drawbacks. First, most ex
Externí odkaz:
https://doaj.org/article/ecf8561d0eee464283b21aaf4134add0
Autor:
Peng Li, Chujie Bai, Lingmin Zhan, Haoran Zhang, Yuanyuan Zhang, Wuxia Zhang, Yingdong Wang, Jinzhong Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Identification of the biological targets of a compound is of paramount importance for the exploration of the mechanism of action of drugs and for the development of novel drugs. A concept of the Connectivity Map (CMap) was previously proposed to conn
Externí odkaz:
https://doaj.org/article/8d1712a3e7a7429fa947fa67aa38d437
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Human brain-related disorders, such as autism spectrum disorder (ASD), are often characterized by cell heterogeneity, as the cell atlas of brains consists of diverse cell types. There are commonality and specificity in gene expression among different
Externí odkaz:
https://doaj.org/article/aee3d2f1f0444e71be469ac592ebebb1
Autor:
Ceyda Kasavi
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Ovarian cancer is the second most common gynecologic cancer and remains the leading cause of death of all gynecologic oncologic disease. Therefore, understanding the molecular mechanisms underlying the disease, and the identification of effective and
Externí odkaz:
https://doaj.org/article/28d6a1d74bdf4a048742abdff8a1f2f3
Autor:
Kang Tang, Jing Tang, Jinfeng Zeng, Wei Shen, Min Zou, Chi Zhang, Qianru Sun, Xiaoyan Ye, Chunwei Li, Caijun Sun, Siyang Liu, Guozhi Jiang, Xiangjun Du
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The immune system is highly networked and complex, which is continuously changing as encountering old and new pathogens. However, reductionism-based researches do not give a systematic understanding of the molecular mechanism of the immune response a
Externí odkaz:
https://doaj.org/article/02a0ec95ad5e464aa322bda1123f8700
Akademický článek
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Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Given expression data, gene regulatory network(GRN) inference approaches try to determine regulatory relations. However, current inference methods ignore the inherent topological characters of GRN to some extent, leading to struct
Externí odkaz:
https://doaj.org/article/27629054ad0742ccbd9cb5ce4cc48dad