Zobrazeno 1 - 10
of 825
pro vyhledávání: '"Gene modification"'
Autor:
Ian Helstrup Nielsen, Anne Bruun Rovsing, Jacob Hørlück Janns, Emil Aagaard Thomsen, Albert Ruzo, Andreas Bøggild, Frederikke Nedergaard, Charlotte Thornild Møller, Thomas Boesen, Søren Egedal Degn, Jagesh V. Shah, Jacob Giehm Mikkelsen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102318- (2024)
To fully utilize the potential of CRISPR-Cas9-mediated genome editing, time-restricted and targeted delivery is crucial. By modulating the pseudotype of engineered lentivirus-derived nanoparticles (LVNPs), we demonstrate efficient cell-targeted deliv
Externí odkaz:
https://doaj.org/article/5b0da4b8e2504d17b7dca8efcfd345d5
Autor:
M. Sababathy, G. Ramanathan, S. Ganesan, S. Sababathy, A.R. Yasmin, R. Ramasamy, J.B. Foo, Q.H. Looi, S.H. Nur-Fazila
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 57 (2024)
Acute respiratory distress syndrome (ARDS) is a critical, life-threatening condition marked by severe inflammation and impaired lung function. Mesenchymal stromal/stem cells (MSCs) present a promising therapeutic avenue due to their immunomodulatory,
Externí odkaz:
https://doaj.org/article/1d5d177bc2dd4b9d877f2e430725bcb6
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Mesenchymal stem cells (MSCs) have garnered significant interest for their tumor-tropic property, making them potential therapeutic delivery vehicles for cancer treatment. We have previously shown the significant anti-tumour activ
Externí odkaz:
https://doaj.org/article/1c3ef94756d04a3982f8cabf16117a44
Autor:
Matteo Rossi, Eytan Breman
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chimeric antigen receptor (CAR) T-cell therapy has proven a breakthrough in cancer treatment in the last decade, giving unprecedented results against hematological malignancies. All approved CAR T-cell products, as well as many being assessed in clin
Externí odkaz:
https://doaj.org/article/6e7ec5b76fa94682acb319f904314817
Autor:
Maciej Superson, Katarzyna Szmyt, Klaudia Wilk-Trytko, Julia Krasnoborska, Sylwia Samojedny, Katarzyna Szymańska, Kamil Walczak
Publikováno v:
Journal of Education, Health and Sport, Vol 66 (2024)
Introduction and Purpose: In last years gene modification technologies such as CRISPR/Cas9 has had a revolutionary impact on the treatment of inherited diseases. Technologies developed from bacterial defense mechanisms, has become a basic tools in sc
Externí odkaz:
https://doaj.org/article/ef58789faf3549999ce0b79330448f60
Publikováno v:
Shipin gongye ke-ji, Vol 44, Iss 23, Pp 387-393 (2023)
β-galactosidase, as a safe and nontoxic enzyme preparation, has been not only widely used in food industry and medical fields, but also has great application potential in biotechnology fields, such as enzyme engineering and protein engineering. Micr
Externí odkaz:
https://doaj.org/article/3fffbd46c2dc465ba80094c72792489a
Autor:
Yanning Wang, Tianyun Gao, WanTing Li, Chenxu Tai, Yuanyuan Xie, Dong Chen, Shuo Liu, Feifei Huang, Wenqing Wang, Yuxin Chen, Bin Wang
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Background The emergence of SARS-CoV-2 becomes life-threatening for the older and immunocompromised individuals, whereas limited treatment is available on these populations. Mesenchymal stromal cells (MSCs) have been reported to be useful in
Externí odkaz:
https://doaj.org/article/8115d2384d3b4706a8292fa544b9ad6e
Publikováno v:
Engineered Regeneration, Vol 4, Iss 1, Pp 81-94 (2023)
Chronic wounds are characterized by prolonged healing processes and poor prognoses, which have substantially impacted human health and daily life. Traditional treatment strategies have various limitations and drawbacks. Therefore, fully effective the
Externí odkaz:
https://doaj.org/article/f533881452984455bee499ccc834a17a
Autor:
Luluk Yunaini, Dwi Ari Pujianto
Publikováno v:
International Journal of Reproductive BioMedicine, Vol 21, Iss 1, Pp 17-32 (2023)
Abstract The identification and characterization of relevant targets are necessary for developing nonhormonal male contraceptives. The molecules must demonstrate that they are necessary for reproduction. As a result, a sophisticated technique is requ
Externí odkaz:
https://doaj.org/article/7bb9610076a64975b3e4aa16526e2971
Publikováno v:
Microorganisms, Vol 12, Iss 1, p 137 (2024)
Transcriptional variation has been studied but post-transcriptional modification due to RNA editing has not been investigated in Plasmodium. We investigated developmental stage-specific RNA editing in selected genes in Plasmodium falciparum 3D7. We d
Externí odkaz:
https://doaj.org/article/840d9ddce7ee4fafab3b87071d4b77c1