Zobrazeno 1 - 10
of 43 828
pro vyhledávání: '"Gene isoform"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6490-6500 (2022)
The cGAS-STING pathway, orchestrating complicated transcriptome-wide immune responses, is essential for host antiviral defense but can also drive immunopathology in severe COVID-19. Here, we performed time-course RNA-Seq experiments to dissect the tr
Externí odkaz:
https://doaj.org/article/478b97444c87401a9f0cd7665272e74a
Autor:
James J. Moresco, Paul Schimmel, Benjamin J. Blencowe, Jolene K. Diedrich, Alan M. Lambowitz, Ryan M. Nottingham, John R. Yates, Douglas C. Wu, Haissi Cui, Justin J. Lim
Publikováno v:
Nature Cell Biology. 25:592-603
Cells respond to perturbations such as inflammation by sensing changes in metabolite levels. Especially prominent is arginine, which has long known connections to the inflammatory response. Here we show that depletion of arginine during inflammation
Akademický článek
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Akademický článek
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Autor:
Weian Zhao, Haobo Bai, Ruimin Liu, Xupei Huang, Qian Lu, Gu Li, Bo Pan, Lingjuan Liu, Jie Tian, Xi Li, Tiewei Lv
Publikováno v:
Genes & Diseases. 9:1689-1700
In the past studies, it is shown that cardiac troponin I (cTnI, encoded by TNNI3), as a cytoplasmic protein, is an inhibitory subunit in troponin complex, and involves in cardiomyocyte diastolic regulation. Here, we assessed a novel role of cTnI as a
Publikováno v:
Virology Journal, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background The Zika virus (ZIKV) is a mosquito-borne flavivirus that causes microcephaly and Guillain-Barré syndrome in infected individuals. To obtain insights into the mechanism of ZIKV infection and pathogenesis, we analyzed the transcri
Externí odkaz:
https://doaj.org/article/2167d12262e241bb9a28fb0006eab5de
Publikováno v:
Seminars in Cancer Biology. 85:123-154
The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway involved in cell proliferation and survival. The three-layered MAPK signaling cascade is initiated upon RTK and RAS activation. Three RAF isoforms ARAF, BRAF and CRAF, and their d
Autor:
Jan Halbritter, Sebastian Sewerin, Ria Schönauer, Dorothee Günzel, Sonja Grunewald, Carsten Bergmann, Angelika Rauch, Steffen Neuber, Jörg Piontek
Publikováno v:
Genes & Diseases. 9:1301-1314
Formation of claudin-10 based tight junctions (TJs) is paramount to paracellular Na+ transport in multiple epithelia. Sequence variants in CLDN10 have been linked to HELIX syndrome, a salt-losing tubulopathy with altered handling of divalent cations
Autor:
Friederike Stephani, Veronika Scheuer, Tobias Eckrich, Kerstin Blum, Wenying Wang, Gerald J. Obermair, Jutta Engel
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Voltage-gated Ca2+ channels are composed of a pore-forming α1 subunit and auxiliary β and α2δ subunits, which modulate Ca2+ current properties and channel trafficking. So far, the partial redundancy and specificity of α1 for α2δ subunits in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52350c83633b6c55e53a87e0ff9d4c7
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 19:2177-2187
Alternative splicing enables a gene translating into different isoforms and into the corresponding proteoforms, which actually accomplish various biological functions of a living body. Isoform-isoform interactions (IIIs) provide a higher resolution i