Zobrazeno 1 - 10
of 406
pro vyhledávání: '"Gene W Yeo"'
Autor:
Evan A Boyle, Gabriela Goldberg, Jonathan C Schmok, Jillybeth Burgado, Fabiana Izidro Layng, Hannah A Grunwald, Kylie M Balotin, Michael S Cuoco, Keng-Chi Chang, Gertrude Ecklu-Mensah, Aleena K S Arakaki, Noorsher Ahmed, Ximena Garcia Arceo, Pratibha Jagannatha, Jonathan Pekar, Mallika Iyer, DASL Alliance, Gene W Yeo
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0293322 (2023)
Disparities for women and minorities in science, technology, engineering, and math (STEM) careers have continued even amidst mounting evidence for the superior performance of diverse workforces. In response, we launched the Diversity and Science Lect
Externí odkaz:
https://doaj.org/article/76bae902ce854f6baefab0308b8fddcd
Autor:
Lauren K Quezada, Wenhao Jin, Yi Chia Liu, Eleanor S Kim, Zhaoren He, Cynthia S Indralingam, Tiffani Tysl, Lara Labarta-Bajo, Ellen J Wehrens, Yeara Jo, Katelynn R Kazane, Christopher Hattori, Elina I Zuniga, Gene W Yeo, John T Chang
Publikováno v:
PLoS Biology, Vol 21, Iss 1, p e3001983 (2023)
During a microbial infection, responding CD8+ T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained protection. An alternative outcome is exhaustion, a state of T cell dysfunction that occurs in t
Externí odkaz:
https://doaj.org/article/7b4ece8f50d847b580332c8f6b7493f7
Autor:
Thomas W Gould, Bertha Dominguez, Fred de Winter, Gene W Yeo, Patrick Liu, Balaji Sundararaman, Thomas Stark, Anthony Vu, Jay L Degen, Weichun Lin, Kuo-Fen Lee
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1007948 (2019)
Glial cells regulate multiple aspects of synaptogenesis. In the absence of Schwann cells, a peripheral glial cell, motor neurons initially innervate muscle but then degenerate. Here, using a genetic approach, we show that neural activity-regulated ne
Externí odkaz:
https://doaj.org/article/21da27eafb4345da988a4e6b546ea84c
Autor:
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Publikováno v:
eLife, Vol 8 (2019)
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either o
Externí odkaz:
https://doaj.org/article/04213ee8809d4946acefc96cd36ba9b2
Autor:
Sarah N Deffit, Brian A Yee, Aidan C Manning, Suba Rajendren, Pranathi Vadlamani, Emily C Wheeler, Alain Domissy, Michael C Washburn, Gene W Yeo, Heather A Hundley
Publikováno v:
eLife, Vol 6 (2017)
ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date. Caenorhabditis elegans lacking
Externí odkaz:
https://doaj.org/article/0be709163d094d89ae3e71f8c13c24d9
Autor:
Gene W Yeo, Xiangdong Xu, Tiffany Y Liang, Alysson R Muotri, Christian T Carson, Nicole G Coufal, Fred H Gage
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 10, Pp 1951-1967 (2007)
Human embryonic stem cells (hESCs) and neural progenitor (NP) cells are excellent models for recapitulating early neuronal development in vitro, and are key to establishing strategies for the treatment of degenerative disorders. While much effort had
Externí odkaz:
https://doaj.org/article/24b182a2e8a24c499670e239a31ce42c
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005123 (2015)
Endogenous retroviruses and retrotransposons contribute functional genetic variation in animal genomes. In mice, Intracisternal A Particles (IAPs) are a frequent source of both new mutations and polymorphism across laboratory strains. Intronic IAPs c
Externí odkaz:
https://doaj.org/article/2924f08e56594c16b79d139586c4abf0
Autor:
Saima Siddiqi, Jia Nee Foo, Anthony Vu, Saad Azim, David L Silver, Atika Mansoor, Stacey Kiat Hong Tay, Sumiya Abbasi, Asraf Hussain Hashmi, Jamal Janjua, Sumbal Khalid, E Shyong Tai, Gene W Yeo, Chiea Chuen Khor
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113258 (2014)
The diagnosis of childhood neurological disorders remains challenging given the overlapping clinical presentation across subgroups and heterogeneous presentation within subgroups. To determine the underlying genetic cause of a severe neurological dis
Externí odkaz:
https://doaj.org/article/c81a7b396d814d1d8ef065e49b068a70
Autor:
Shaun E Hunter, Emily F Finnegan, Dimitrios G Zisoulis, Michael T Lovci, Katya V Melnik-Martinez, Gene W Yeo, Amy E Pasquinelli
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003353 (2013)
The let-7 microRNA (miRNA) regulates cellular differentiation across many animal species. Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigen
Externí odkaz:
https://doaj.org/article/9e79cabe4df8400b9a6000926f1efd08
Autor:
Maria C N Marchetto, Gene W Yeo, Osamu Kainohana, Martin Marsala, Fred H Gage, Alysson R Muotri
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7076 (2009)
Genetic reprogramming of somatic cells to a pluripotent state (induced pluripotent stem cells or iPSCs) by over-expression of specific genes has been accomplished using mouse and human cells. However, it is still unclear how similar human iPSCs are t
Externí odkaz:
https://doaj.org/article/76bad8f8eba74af398bf1179d85e48ba